Hepatitis C Virus Infection in Chronic Liver Disease in Somalia

Aceti, Antonio; Taliani, Gloria; Bruni, Renato; Sharif, Omar; Moallin, K A; Celestino, D; Quaranta, Giorgio; Sebastiani, A.

doi:10.4269/ajtmh.1993.48.581

Cited by 18 publications

(15 citation statements)

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“…Although HCV has been implicated in non A non B hepatitis in CLD development in parts of Asia, the incidence of this virus was previously reported to be low in Kano, Nigeria 1. The rate observed in this study is, however, consistent with 28% reported from Lagos,12 but higher than 20.6% from Somalia13 and 24.1% from Bangladesh,14 and lower than that reported by Singh et al ., in India 15. This result also showed that about 41.7% of patients with CLD tested positive to HBsAg, higher percentage than ours was reported by some authors elsewhere.…”

Section: Discussionsupporting

confidence: 84%

Serum alpha-fetoprotein level is higher in hepatitis C than hepatitis B infected chronic liver disease patients

et al. 2013

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Background:The frequency of raised serum alpha-fetoprotein may vary in relation to hepatitis B or C infection in chronic liver disease (CLD). The study evaluated the frequency of hepatitis B and C in patients with chronic liver disease and correlated the levels of serum alpha-fetoprotein with hepatitis B and C infection in the patients.Materials and Methods:Eighty-six patients with CLD were recruited for the study. Fifty subjects, with no CLD were used as control. Hepatitis B surface Antigen (HBsAg) and hepatitis C antibody were determined using enzyme-linked immunosorbent assay (ELISA) technique (Human diagnostics, Germany and HCV Murex 40 Anhet laboratories, USA) while liver function tests were evaluated using express plus chemistry auto analyzer. Alpha-fetoprotein was assayed using ELECSYS 1010 auto analyser.Results:There were 60 males and 26 females, with a mean age of 46 + 6.5 years, while the controls were 25 males and 25 females with a mean age of 41 ± 2.5 years. Thirty-six subjects (41.7%) were seropositive for HBsAg while 24 (27.9%) were seropositive for Hepatitis C Virus (HCV) antibody. The mean alpha fetoprotein level was 359 ± 9.9 ng/mL while mean control value was 1.93 ± 0.24 ng/mL. Liver function test parameters were elevated compared with control subjects (P < 0.001). The increase in serum alpha-fetoprotein was higher (P < 0.001) in HCV than HBsAg positive patients.Conclusion:Serum alpha-fetoprotein level was highest in HCV compared to HBsAg positive and hepatitis negative patients with CLD.

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Section: Discussionsupporting

confidence: 84%

Serum alpha-fetoprotein level is higher in hepatitis C than hepatitis B infected chronic liver disease patients

et al. 2013

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“…Despite the potential utility of anti-HCV EIA S/C ratio values and surrogate markers in evaluating test results, few studies have evaluated their utility in the setting of diagnostic testing of populations at high risk for HCV infection (3,8,15 ). Individuals seeking care in Veterans Affairs Medical Centers have been recognized as a population at high risk of HCV infection.…”

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confidence: 99%

“…Although EIA tests provide a quantitative absorbance result [often reported as the signal to cutoff (S/C) ratio], they are usually reported simply as positive or negative. Several studies using first-and second-generation anti-HCV EIA tests have shown that samples with absorbance values just slightly above the cutoff value have a significantly greater likelihood of representing false-positive results compared with those with higher values (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17).…”

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confidence: 99%

Low-Positive Anti-Hepatitis C Virus Enzyme Immunoassay Results: An Important Predictor of Low Likelihood of Hepatitis C Infection

Dufour

Talastas²,

Fernandez³

et al. 2003

Clinical Chemistry

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“…Although usually reported as positive or negative, the results are actually measured as an absorbance signal that is compared with that of a cutoff value; results above the cutoff are reported as positive, whereas those below the cutoff are called negative. Several studies in the blood bank literature have shown that positive samples with a low signal-to-cutoff (S/C) ratio are usually found to be negative for anti-HCV antibodies by recombinant immunoblot assay (RIBA) (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). To minimize the likelihood of false-positive anti-HCV results, the CDC has recommended confirmation of all anti-HCV results by either RIBA or HCV RNA assays (17 ).…”

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confidence: 99%