Hepatitis C Virus Infection in Patients with Nonalcoholic Chronic Liver Disease

Sánchez-Tapias, José M.; Barrera, J.M.; Costa, J.; Ercilla, M. G.; Parés, Albert; Comalrrena, Lluis; Soley, Francesc; Bruix, Jordi; Calvet, Xavier; Gil, Maria Pilar; Mas, Antoni; Bruguera, Miquel; R, Castillo; Rodés, Joan

doi:10.7326/0003-4819-112-12-921

Cited by 99 publications

(30 citation statements)

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“…Therefore, our findings confirm the virus C as the most important agent of non-A, non-B hepatitis in hemodialysis patients [7,14,[18][19][20], and infection by this virus was related to a longer time on dial ysis and transfusions [14-16, 18, 19, 26], but there are other unidentified mechanisms of transmission of the virus apart from the parenteal administration of blood products [9,14,16], as 5 patients with anti-HCV antibody had never been transfused.…”

Section: Discussionsupporting

confidence: 54%

Hepatitis C Antibody after Kidney Transplantation: Clinical Significance

Marcén

Gámez²,

Mateos³

et al. 1993

Am J Nephrol

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The prevalence of antibodies to hepatitis C virus (HCV) was investigated in 231 renal transplantation recipients, by a first- and second-generation EI A assay and a second-generation immunoblot assay (4-RIBA). Before transplantation, prevalence of anti-HCV was 22.6% and was related to the time on dialysis (p < 0.01), transfusions (p < 0.01) and previous history of chronic liver disease (p < 0.01. Following transplantation, 32 patients (13.9%) were anti-HCV positive by the first-generation enzyme immunoassay (EIA) and it increased to 57 patients (24.7%) when anti-HCV was measured by the second-generation EIA. The 4-RIBA assay confirmed the positivity in 46 patients (80.7%), 11 patients (19.3%) were indeterminate. Seroconversion after grafting was observed in 7 negative patients, and another 7 patients became negative after the procedure. The presence of anti-HCV antibody after transplantation was determined by the patient status on dialysis, 80% of them being positive before surgery. Twenty-one 4-RIBA-positive transplantation patients (45.7%) had persistently or intermittently abnormalities on liver function tests, suggesting chronic liver disease. A liver biopsy performed on 10 of these patients showed; chronic active hepatitis in 6, chronic persistent hepatitis in 2, and chronic lobular hepatitis in the other 2 patients. Another 23 4-RIBA-positive transplantation patients had normal alanine aminotransferase levels despite long follow-up (66.2 ± 32.2 months). The prevalence of anti-HCV antibody can be underestimated if the antibody is measured by first-generation EIA alone. About 50% ofpatients with anti-HCV had chronic liver disease, and the histological findings suggested a possible evolution to cirrhosis. The significance of the coexistence of anti-HCV and normal function test needs further evaluation.

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Section: Discussionsupporting

confidence: 54%

Hepatitis C Antibody after Kidney Transplantation: Clinical Significance

Marcén

Gámez²,

Mateos³

et al. 1993

Am J Nephrol

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“…However the preval ence of anti-HCV Ab among patients with non-A, non-B hepatitis differs among studies [4][5][6][7], Such differences may be explained if viruses other than HCV cause non-A, non-B hepatitis. In addition, Ab determinations may yield false-negative results, especially if they are per formed too early or too late in the course of the infection [4], Finally, a group of investigators have reported a high incidence of false-positive results in patients with auto immune hepatitis, which they attributed to nonspecific binding of circulating IgG to the ELISA plates [8], More recently, another group of investigators have suggested that the presence of low-titer autoantibodies represents an epiphenomenon and does not invalidate the serologic diagnosis of HCV infection in patients with chronic hep atitis [7], The incidence of false-positive tests in other forms of liver disease is not well established [5,7].…”

mentioning

confidence: 95%

Prevalence of Antihepatitis C Antibodies in Patients Treated with Continuous Ambulatory Peritoneal Dialysis and Hemodialysis

Pérez‐Fontán¹,

Moncalián²,

Rodríguez‐Carmona³

et al. 1991

Nephron

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“…2 Most of those infected with HCV acquired the disease 10 to 20 years ago, before identification of the virus and the availability of screening tests. [3][4][5] The recognition of potential risk factors and the improved safety of the blood supply have led to a dramatic decrease in the incidence of new HCV infections in recent years. However, the overall prevalence of chronic infection has not fallen because most acutely infected patients develop chronic infection.…”

mentioning

confidence: 99%