Hepatitis C Virus Infection Associated With an Increased Risk of Deep Vein Thrombosis

Abstract

The association between the hepatitis C virus (HCV) infection and the risk of myocardial infarction (MI) and stroke has been previously investigated. However, the association between the HCV infection and the risk of venous thromboembolism (VTE) has not been extensively discussed.Using the Longitudinal Health Insurance Database 2000 (LHID2000), we selected 3686 patients with newly diagnosed HCV infection. We randomly selected 14,744 people with no HCV or hepatitis B virus (HBV) infection as comparison group and frequency matched them with patients with HCV infection according to their age, sex, and index year. The incidence density rates and hazard ratios (HRs) of deep vein thrombosis (DVT) and pulmonary embolism (PE) were calculated until the end of 2011.The mean follow-up duration of 5.14 years for the HCV cohort and 5.61 years for the non-HCV cohort, the overall incidence density rates of DVT were 7.92 and 3.51 per 10,000 person-years in the non-HCV group, and the HCV groups, respectively (crude HR = 2.25; 95% confidence interval [CI] = 1.21–4.21). After adjusted for age, sex, and comorbidities, the risk of DVT remained significantly higher in the HCV group than in the non-HCV group (adjusted HR = 1.96; 95% CI = 1.03–3.73). The overall incidence density rates of PE in the HCV and non-HCV groups were not significantly different (crude HR = 2.20; 95% CI = 0.94–5.14).HCV infection is associated with the risk of DVT in a long-term follow-up period.

Reply to: “Therapeutic drug monitoring for sofosbuvir and daclatasvir in transplant recipients with chronic hepatitis C and advanced renal disease”

“…From a safety perspective, we observed a good clinical and biological tolerance for all patients. The two thrombo-embolic events reported by Vionnet et al might be related with the higher risk of thrombosis associated with the HCV infection [7]. Recently, our results were confirmed by others, who reported a very high efficacy and good tolerability of SOF 400 mg QD in hemodialysis or severe CKD patients [8,9].…”

An Independent Risk of Gout on the Development of Deep Vein Thrombosis and Pulmonary Embolism

“…The International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) code was used for coding the diseases of interest in the present study. 29 , 30 To prevent medical fraud with overbilling for healthcare or inappropriate charges based on unconfirmed diagnoses, NHI sets strict rules on disease coding and regularly monitors coding and claims submitted for reimbursement by all participants of NHI beneficiaries. NHIRD provides reliable information for the proposed studies to explore the risk of VTE development in patients with gout.…”

Incidence of Venous Thromboembolism in Asian Populations: A Systematic Review

“…117 No. 12/2017 tuberculosis21 and hepatitis C virus infection22 compared with controls (►Table 3). Two studies only recorded VTE incidence, and both showed significantly higher rates in patients with dermatomyositis (HR: 11.1; 95% CI: 5.2, 23.6) and liver cirrhosis (HR: 7.7; 95% CI: 5.2, 11.4) 23 compared with controls.…”