Hepatitis C virus infection and risk of osteoporosis: A meta-analysis

Wijarnpreecha, Karn; Panjawatanan, Panadeekarn; Phatharacharukul, Parkpoom; Ungprasert, Patompong

doi:10.4103/sjg.sjg_452_16

Cited by 23 publications

(9 citation statements)

References 28 publications

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“…Other studies had also suggested that hepatitis B and C virus serologically positive respondents show decreased BMD in the femur and spine compared to negative respondents, which may increase the risk of osteoporosis ( 37 – 39 ). In a study involving 51,144 respondents on the relationship between positive hepatitis B surface antigen and BMD in Taiwan ( 37 ), the results of their multiple regression analysis suggested a negative association between HBV positivity and BMD.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, the results from a national data study in Korea ( 38 ) suggested that serological positivity of hepatitis B is significantly associated with reduced BMD in men. In terms of hepatitis C-related studies, a meta-analysis ( 39 ) study suggested an increased risk of osteoporosis in patients with HCV infection. However, we did not believe that the results of these studies can be extrapolated to the BMD status of adults with viral hepatitis in the United States.…”

Section: Discussionmentioning

confidence: 99%

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Seropositive for hepatitis B and C viruses is associated with the risk of decreased bone mineral density in adults: An analysis of studies from the NHANES database

et al. 2023

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BackgroundSome studies had reported that patients with viral hepatitis are at increased risk of reduced bone mineral density and even osteoporosis. However, the interaction between reduced bone mineral density (BMD) and viral hepatitis remains inconclusive. Therefore, our study collected hepatitis test results and bone mineral density from respondents in the NHANES database. The aim of this study was to investigate whether there is an association between hepatitis and a decrease in bone mineral density.MethodsThe respondents with both hepatitis- and BMD-related indicators from the NHANES database in the United States from 2005–2010, 2013–2014, to 2017–2020 were collected for this study. BMD were compared between respondents who were positive and negative for respondents related to hepatitis B and C. BMD was measured using dual-energy X-ray absorptiometry of the femur and lumbar spine. Finally, multiple regression analysis was performed between hepatitis B surface antigen (HBsAg) and hepatitis C RNA (HCV-RNA) and BMD in the respondents.ResultsA total of 15,642 respondents were included in the hepatitis B surface antigen-related survey. Of these, 1,217 respondents were positive for hepatitis B surface antigen. A total of 5111 hepatitis C RNA-related responders were included. Hepatitis C RNA-positive had 268 respondents. According to the results of the multiple regression analysis, the femoral BMD was significantly lower in HBsAg (+) respondents compared to HBsAg (–) respondents: −0.018 (−0.026, −0.009) (P < 0.01). Moreover, spinal BMD was significantly lower in HBsAg (+) respondents compared to HBsAg (–) respondents: −0.020 (−0.030, −0.010) (P < 0.01). According to the results of multiple regression analysis for hepatitis C RNA, HCV-RNA (+) respondents had significantly lower BMD compared to HCV-RNA (–) respondents: −0.043 (−0.059, −0.026) (P < 0.01).ConclusionDuring the analysis of respondents in the NHANES database in the United States, positive tests for hepatitis B surface antigen and hepatitis C RNA were found to be associated with a reduction in BMD. Positive serology for these hepatitis indicators may increase the risk of reduced BMD. Of course, this conclusion still needs to be further confirmed by more large clinical trials.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Seropositive for hepatitis B and C viruses is associated with the risk of decreased bone mineral density in adults: An analysis of studies from the NHANES database

et al. 2023

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“…Synovial fluid pressure within the joint may cause osteolysis, as sustained elevated pressure can alter normal bone perfusion and oxygenation, resulting in bone necrosis [ 7 ]. Furthermore, the previously reported diagnosis of C hepatitis should be considered, as there is a higher risk of osteoporosis among hepatitis C virus-infected patients [ 8 ], and these patients may have a higher risk of surgical complications and a revision rate [ 9 ]. A polyethylene insert was used and, taking into account the massive osteolytic process around the acetabulum, several authors also emphasise particle-associated wear osteolysis, which occurs when the polyethylene liner is completely worn through, the metallic femoral head now articulates with a metallic shell, and small fibrils are formed on the surface of the polymers, which can detach and accumulate in the joint cavity, activating the osteolytic cascade [ 2 , 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Massive Periprosthetic Osteolysis Spreads to the Soft Tissue and Pelvic Region after Primary Total Hip Replacement: A Case Report

Ponomarjova¹,

Jakovicka²,

Studers³

2023

JOCR

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Introduction: Periprosthetic osteolysis (PPOL) is a serious complication after total hip replacement and requires immediate action to prevent further spread to nearby tissues and has the opportunity to restore hip function successfully. We present the case of PPOL of a patient with a challenging course of treatment. Case Report: We report a 75-year-old patient with PPOL that spreads to the soft tissues and pelvic region 14 years after primary total hip arthroplasty. At all stages of treatment, an elevated neutrophil-dominant cell count was detected in the analysis of synovial fluid aspiration of the left hip joint without detection of microbiological culture. Due to severe bone loss and general patient condition, no further surgical treatment was indicated, and there is no clear vision of future actions. Conclusion: Management of severe PPOL can be challenging, as there are limited surgical treatment options with a good long-term prognosis. If an osteolytic process is suspected, it should be treated as soon as possible to avoid more severe progression of the complications. Keywords: Periprosthetic osteolysis, total hip replacement, bone lesion.

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“…Other mechanisms include pro-inflammatory cytokines, chemokines, and other immune-mediated mechanisms. Finally, although the exact cellular and molecular mechanisms behind this association are not completely understood, chronic HCV infection might increase the risk of osteoporosis in patients with thalassemia as already shown in the general population [ 104 , 105 ]. In this regard, according to Meloni et al (2023), HCV represents an independent risk factor for low bone mineral density and osteocalcin may play a role in the loss of bone mass associated with HCV infection [ 106 ].…”

Section: Hcv and Extrahepatic Manifestations In Patients With Beta Th...mentioning

confidence: 99%

Hepatitis C and Thalassemia: A Story with (Almost) a Happy Ending

Origa

2023

Pathogens

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Donor screening has nearly eliminated the risk of hepatitis C virus post-transfusion transmission in resource-rich settings. Moreover, the use of direct antiviral agents made it possible to treat the majority of patients with thalassemia and hepatitis C. However, this achievement, while extremely significant, does not erase the effects of the virus in terms of fibrogenesis and mutagenic risk, and adult patients with thalassemia are facing the long-term consequences of the chronic infection both on the liver and extrahepatically. As in the general population, it is in mainly patients with cirrhosis who are increasing in age, even though they are now HCV RNA-negative, who are at risk of hepatocellular carcinoma, which continues to be statistically much more frequent in individuals with than without thalassemia. In certain resource-limited settings, the World Health Organization has estimated that up to 25 percent of blood donations do not undergo screening. It is therefore not surprising that hepatitis virus infection is still the most prevalent in patients with thalassemia worldwide.

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Hepatitis C virus infection and risk of osteoporosis: A meta-analysis

Cited by 23 publications

References 28 publications

Seropositive for hepatitis B and C viruses is associated with the risk of decreased bone mineral density in adults: An analysis of studies from the NHANES database

Seropositive for hepatitis B and C viruses is associated with the risk of decreased bone mineral density in adults: An analysis of studies from the NHANES database

Massive Periprosthetic Osteolysis Spreads to the Soft Tissue and Pelvic Region after Primary Total Hip Replacement: A Case Report

Hepatitis C and Thalassemia: A Story with (Almost) a Happy Ending

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