Hepatitis C Virus Infection and Coinfection With Human Immunodeficiency Virus

Hadigan, Colleen; Kottilil, Shyamasundaran

doi:10.1001/jama.2011.975

Cited by 42 publications

(29 citation statements)

References 76 publications

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“…After clinical or subclinical HCV infection up to 25 % of people will spontaneously clear the virus [2]. There is significant excess mortality attributable to liver-related injury in those with chronic HCV infection compared to the general population, and among those with chronic HCV infection, progression of the disease varies widely [3, 4]. …”

Section: Introductionmentioning

confidence: 99%

Spontaneous viral clearance of hepatitis C virus (HCV) infection among people who inject drugs (PWID) and HIV-positive men who have sex with men (HIV+ MSM): a systematic review and meta-analysis

et al. 2016

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BackgroundHepatitis C virus (HCV) infection causes significant morbidity and mortality among people who inject drugs (PWID) and HIV+ men who have sex with men (MSM). Characterizing spontaneous viral clearance of HCV infection among PWID and HIV+ MSM is important for assessing the burden of disease and treatment strategies in these populations.MethodsElectronic and other searches of medical literature were conducted. Reports were eligible if they presented original data from upper-middle- and high-income countries on laboratory-confirmed HCV infection and spontaneous viral clearance among PWID or HIV+ MSM. Pooled estimates of spontaneous viral clearance were generated using fixed-effect and random-effects models. Meta-regression examined potential predictors related to individual characteristics and research methodology.ResultsThe meta-analysis estimated that spontaneous viral clearance occurs in 24.4 % of PWID and 15.4 % of HIV+ MSM. In univariate meta-regression among PWID, male sex and age were significantly associated with spontaneous viral clearance, and in multivariate analysis, male sex and HIV positivity were predictors of spontaneous viral clearance; among HIV+ MSM no variables were found to affect spontaneous viral clearance.ConclusionThe variability in estimates of spontaneous viral clearance between HIV+ MSM and PWID suggests the impact of HIV co-infection and HCV re-infection. Due to limited data on additional factors that may affect the natural history of HCV, more research is needed to further understand spontaneous viral clearance in these risk groups.Protocol registrationThe protocols for the PWID and HIV+ MSM research were registered with PROSPERO (CRD42014008805; CRD42013006462).Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-016-1807-5) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Spontaneous viral clearance of hepatitis C virus (HCV) infection among people who inject drugs (PWID) and HIV-positive men who have sex with men (HIV+ MSM): a systematic review and meta-analysis

et al. 2016

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“…Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) significantly affect the morbidity and mortality of infected individuals globally [1-3]. Although HCV and HIV are both bloodborne pathogens that share similar modes of transmission, the transmission efficiency of each virus varies[4].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and correlates of HCV monoinfection and HIV and HCV coinfection among persons who inject drugs in Vietnam

Zhang¹,

Celentano²,

Minh

et al. 2015

European Journal of Gastroenterology &Amp; Hepatology

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Background Vietnam bears a high burden of HCV and HIV infection among persons who inject drugs (PWID). The high prevalence of HCV and HIV occur in a context of stigma and limited prevention interventions for PWID. Objectives This study aims to estimate the prevalence of HCV, HIV and HIV/HCV coinfection among PWID, and also to explore their associations with lifetime injection behaviors. Methods A total of 1434 PWID were recruited in Thai Nguyen Province, in Vietnam, between 2005 and 2007. Participants responded to a structured questionnaire and provided blood samples at baseline. A cross-sectional analysis of data collected at baseline was conducted. Factors associated with HCV monoinfection and, HIV/HCV coinfection were evaluated using multinomial logistic regression. Results The prevalence of HIV and HCV were 35.1% and 88.8% respectively and the prevalence of HIV/HCV coinfection, HCV monoinfection were 34.8%and 53.9%, respectively. After adjusting for confounders in multivariate analysis, ever reusing a syringe and a needle was significantly associated with HIV monoinfection (AOR, 3.13; 95% CI, 1.99-4.94), and HIV/HCV coinfection (AOR, 3.34; 95% CI, 2.02-5.51). Ever sharing diazepam or novocaine was also significantly associated with HIV monoinfection (AOR, 2.14; 95% CI, 1.38-3.32) and HIV/HCV coinfection (AOR, 2.47; 95% CI, 1.57-3.90). Conclusion Our findings demonstrated a high burden of HIV and HCV infection among PWID in Vietnam. Lifetime injection behaviors, including sharing diazepam or novocaine, may account for the high prevalence of HIV and HCV. Improving prevention and ensuring access to care remains critically important for this vulnerable population.

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“…Globally an estimated 180 million people, or roughly 3% of the world's population, are currently infected. 1 The burden of disease is greatest in developing countries: the highest reported prevalences are in China (3.2%), Egypt (22%) and Pakistan (4.8%). 2 In light of the above, the need to improve access to care and treatment for patients with a chronic HCV infection is receiving increasing attention.…”

Section: Introductionmentioning

confidence: 99%

Chronic hepatitis C treatment outcomes in low- and middle-income countries: a systematic review and meta-analysis

Ford

Kirby

Singh

et al. 2012

Bull. World Health Organ.

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Hepatitis C Virus Infection and Coinfection With Human Immunodeficiency Virus

Cited by 42 publications

References 76 publications

Spontaneous viral clearance of hepatitis C virus (HCV) infection among people who inject drugs (PWID) and HIV-positive men who have sex with men (HIV+ MSM): a systematic review and meta-analysis

Spontaneous viral clearance of hepatitis C virus (HCV) infection among people who inject drugs (PWID) and HIV-positive men who have sex with men (HIV+ MSM): a systematic review and meta-analysis

Prevalence and correlates of HCV monoinfection and HIV and HCV coinfection among persons who inject drugs in Vietnam

Chronic hepatitis C treatment outcomes in low- and middle-income countries: a systematic review and meta-analysis

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