Hepatitis C Virus Infection and Membranous Glomerulonephritis

Rollino, Cristiana; Roccatello, Dario; Giachino, Osvaldo; Basolo, B; Piccoli, Giuseppe

doi:10.1159/000186573

Cited by 90 publications

(29 citation statements)

References 2 publications

(2 reference statements)

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“…Hepatitis C virus (HCV)infection may be associated with several extrahepatic syndromes, especially immunologically mediated renal disease (1)(2)(3)(4)(5)(6)(7). Yamabe et al (8) have firstly demonstrated the glomerular deposition of HCV in membranoproliferative glomerulonephritis (MPGN)patients.…”

Section: Introductionmentioning

confidence: 99%

Glomerulonephritis in Autopsy Cases with Hepatitis C Virus Infection.

et al. 1998

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The glomerular changes of 188 consecutive autopsy cases with hepatitis C virus (HCV) infection were studied. The glomerular changes were classified as follows: Category I: membranoproliferative glomerulonephritis (MPGN; 21 cases, ll.2 %), 2) Category II: membranous nephropathy (MN; 5 cases, 2.7 % ), 3) Category III: mesangial proliferative glomerulonephritis (MesGN; 33 cases, 17.6%), 4) Category IV: mesangial thickening type without proliferative mesangial cell (MT; 44 cases, 23.4%), and 5) Category V: almost normal glomeruli (85 cases, 45.2 %). Glomerulonephritis was defined as glomeruli with an increase in mesangial matrix or a thickening of the capillary walls in the glomeruli; categories I-IV corresponded to glomerulonephritis in this study. Multivariate analysis, using a multiple logistic model, indicated that glomerulonephritis with HCVinfection was the most strongly correlated to the existence ofesophagogastric varices. Abnormalurinalysis, that is transient or continuous microhematuria or proteinuria, was observed in only 23 (12.2%) cases. These results showed that in HCV-RNA positive patients with esophagogastric varices the possibility of glomerulonephritis should be considered. (Internal Medicine 37: 836-840, 1998)

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Section: Introductionmentioning

confidence: 99%

Glomerulonephritis in Autopsy Cases with Hepatitis C Virus Infection.

et al. 1998

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“…Many patients with mild liver disease have more major systemic symptoms with chronic fatigue (Foster et al, 1998). Other extrahepatic diseases related to HCV infection include glomerulonephritis, cryoglobulinaemia and vasculitis (Johnson et al, 1993;Rollino et al, 1991;Agnello et al, 1992). Individual patients may be concerned regarding transmission of HCV to others and until effective vaccines are developed antiviral therapy is also important in controlling disease spread.…”

Section: Targeting Therapymentioning

confidence: 99%

Treatment of Chronic Viral Hepatitis

Main

McCarron

1998

Antivir Chem Chemother

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Interferon-α therapy has proved effective for up to 40% of patients with adult-acquired chronic hepatitis B virus (HBV) infection and for 20-25% of those with chronic hepatitis C virus (HCV) infection. Nucleoside analogues, such as lamivudine and famciclovir, are showing promise as antiviral agents for chronic HBV and the combination of interferon-α and ribavirin is proving to be successful therapy for 40-50% of patients with chronic HCV. In this article we review current therapy and discuss future strategies of the therapy of chronic viral hepatitis.

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“…Serum al bumin was 12 g/1 and total protein 46 g/l. A wide spectnim of glomerular morpho logical changes can be observed in HIV-in fected patients but, in fact, FSGS is found in most of them, and membranous nephropathy (MN) has been exceptionally reported [1], On the other hand, HCV infection has been re cently described associated with MN [3] and…”

Section: Membranous Nephropathy a Ssociated W Ith Hepatitis C Virus Imentioning

confidence: 99%