Hepatitis C virus infection among paediatric patients attending University of Assiut Hospital, Egypt

Kalil, Kotb Abbass Metwalley; Farghally, H. S.; Hassanein, Khaled; Abd‐Elsayed, Alaa; Hassanein, F

doi:10.26719/2010.16.4.356

Cited by 18 publications

(16 citation statements)

References 12 publications

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“…This study revealed that the prevalence of HCV seropositivity was 4.7% while it was 5.8% in a previous study among healthy Egyptian children selected from 10 schools in Alexandria with HCV viremia in 75%, [15] 8% in children aged 2 months-15 years attending pediatric department, Assiut University, [16] 1.9% for children aged <9 years in a community based study in a village in Assiut governorate, [4] 2.02% among children aged 1-9 years collected from Cairo University pediatric hospital, [17] and 3.6% seroprevalence rate in India. [18] This difference may be attributed not only to the difference in the study design but also to the age of the In our study, the frequency of HCV positivity by PCR among ELISA positive cases was 75% in agreement with other studies.…”

Section: Discussionmentioning

confidence: 52%

Prevalence of hepatitis C virus infection and response to hepatitis B vaccination among Egyptian school children

Abed¹,

Elawady²,

Arafa³

et al. 2017

Int J Med Sci Public Health

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Background: A prevalence of hepatitis C virus (HCV) infection is relatively low in children as it was 3% and 9% in the upper and lower Egypt areas, respectively. Most chronic hepatitis C patients are asymptomatic and unaware of their disease before diagnosis. Similarly, hepatitis B virus (HBV) is a major cause of chronic liver disease, particularly cirrhosis and hepatocellular carcinoma, though HBV incidence and infection has been markedly reduced after mass vaccination programs. Objectives: To identify the prevalence and risk factors of asymptomatic HCV infection and evaluate response of hepatitis B vaccination among Egyptian children. Materials and Methods: Six hundred children (6-17 years) were screened for HCV antibodies (HCV Ab) and hepatitis B surface antibody concentration (HBsAb) was quantitated by enzyme-linked immunosorbent assay. HCV Ab-seropositive was tested for HCV ribonucleic acid by real-time-polymerase chain reaction, complete blood count, and liver function tests. Results: 4.7% were diagnosed as HCV Ab-seropositive and 58.5 % as HBsAb-seroprotective (HBsAb ≥10 mIU/ml). History of exposure to blood transfusion, frequent intravenous injection, history of prior hospitalization and blood exposure were significantly more likely to be among HCV seropositive. Blood transfusion was considered the most predictable risk factor for HCV infection. There was a significant decrease in HBsAb concentration with increasing age. Conclusion: Booster dose of hepatitis B vaccine should be considered to enhance immune protection of the vaccine especially in our endemic area. ABSTRACT Access this article onlineWebsite: http://www.ijmsph.com Quick Response code

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Section: Discussionmentioning

confidence: 52%

Prevalence of hepatitis C virus infection and response to hepatitis B vaccination among Egyptian school children

Abed¹,

Elawady²,

Arafa³

et al. 2017

Int J Med Sci Public Health

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“…Various other studies report that, there is evidence of ongoing HCV incidence at dental and medical facilities [34,35], Although most studies have not found dental procedures tо be a risk for HCV in Egypt оr elsewhere [36,37].…”

Section: Discussionmentioning

confidence: 99%

“…Mohlman et al [28] reported that not a statistically significant assоciatiоn between HCV pоsitivity and blооd dоnation [28]. However, many оther studies repоrted that, there is relation between these risk factors and increasing prevalence of anti-HCV [19,34,38,39].…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Hepatitis C Virus among Population in Luxor Governorate, Egypt

2017

JHVRV

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Background: Hepatitis C virus (HCV) is one of the hepatitis viruses that transmitted through blоod or blоod products. HCV has been implicated as a major reason of chronic liver disease and hepatоcellular carcinoma worldwide. Aim:To determine the seroprevalence of HCV antibodies among community in Luxor governorate, Egypt. Moreover to assess if there is any association with the population group, sex, age and other different risk factors. Method:We randomly selected 745 blood samples; from males and females of different ages. Samples were collected from Luxor governorate, Egypt. Seras from all subjects were tested for hepatitis C virus antibodies using rapid test method and confirmed with the enzyme linked immunosorbent assay (ELISA) third generation. Results:Our results show that 584 (78.40 %) of the community were males and most of them were aged between 31 and 50 years. Thirty two (5.48%) from blood samples of males were anti-HCV seropositive and the highest prevalence of anti-HCV (7.22%) of age groups from 41-50 years. One hundred and sixty one (21.60%) from the community were female and most of them aged between 41 -65 years. Six (3.73%) of female subjects tested positive for anti-HCV and the highest prevalence of anti-HCV (4.87%) with age groups from 31-40 years. Four risk factors reflecting high mechanisms of HCV transmission have been associated with HCV infection including residing in rural areas, no education, blood transfusion and dental treatment. Exposures to surgery, history of schistosomiasis show low association with Anti-HCV. Among the community exposures, including blood donation and alcohol consumption but these associations are not important.

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“…HCV transmission in Egypt is primarily associated with inadequate infection control during dental and medical care procedures [26]. Kalil et al stated that various medical procedures even if minor contribute to HCV susceptibility [27]. Barakat and Elbashir reported that history of previous blood transfusion, circumcision for boys by informal health care providers, surgical intervention, and dental treatment are the most significant risk factors for HCV infection [22].…”

Section: Discussion:-mentioning

confidence: 99%

Prevalence of hepatitis B and C among some high risk groups in Egyptian children attending Benha University hospital.

Elsherbiny¹,

Abed²,

Mohammed³

et al. 2017

IJAR

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Background: Hepatitis C virus (HCV) is a global health problem especially in Egypt. Hepatitis B virus (HBV) is a major cause of chronic liver diseases especially cirrhosis and hepatocellular carcinoma. HBV incidence is markedly reduced after mass vaccination programs application. Objectives: to detect HCV and HBV seroprevalence among some high risk children with molecular confirmation of viremia by real-time PCR for seropositive cases. Materials and methods: A comparative cross sectional study was conducted on 5 groups of Egyptian children attending Benha University Hospital (diabetes mellitus, thalassemia, hemodialysis, previously exposed to surgery and healthy children). All children were subjected to full history taking, physical examination and laboratory investigations including HCV antibodies by 4 th generation ELISA, HBsAg, HBsAb using ELISA, liver function tests and CBC, HCV and HBV viremia detection by real-time PCR for ELISA positive subjects. Results: HCV seropositivity was detected in 5%, 15%, 30%, 50% and 10% for healthy, diabetic, thalassemia, hemodialysis and previously exposed to surgery, respectively. As regard HBV, only a hemodialysis case was positive for both HBsAg and HBV-DNA. Low social class, blood transfusion, frequent intravenous injection, previous surgery and previous hospitalization are major risk factors for HCV transmission. Conclusion:The study revealed high HCV seropositivity prevalence among the studied high risk groups. PCR should be done for all HCV seropositive cases to confirm the presence of viremia.

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Hepatitis C virus infection among paediatric patients attending University of Assiut Hospital, Egypt

Cited by 18 publications

References 12 publications

Prevalence of hepatitis C virus infection and response to hepatitis B vaccination among Egyptian school children

Prevalence of hepatitis C virus infection and response to hepatitis B vaccination among Egyptian school children

Seroprevalence of Hepatitis C Virus among Population in Luxor Governorate, Egypt

Prevalence of hepatitis B and C among some high risk groups in Egyptian children attending Benha University hospital.

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