Hepatitis C Virus Infection

Tai, Andrew W.; Chung, Raymond T.

doi:10.1002/9781118512074.ch96

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Table 1 Optimization Of Reaction Conditions ...1

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2023

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“…There are various routes available to synthesize thioglycosides, among all the methods Lewis acid mediated transformation of acetylated sugars was extensively studied. 6–8 Glycals are the sugar enol ethers having unsaturation in the ring and the Ferrier glycosidation reaction is the most common reaction to construct the thioglycosides from glycals. 9 10 11 Thioglycosidation in glycals utilizing the C2 position was merely studied albeit few reports are available.…”

Section: Table 1 Optimization Of Reaction Conditions ...mentioning

confidence: 99%

Site-Selective Lewis Acid Mediated Transformation of Pseudo Glycals to 1-Deoxy-2-thioaryl/alkyl Glycosides

et al. 2023

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Herein, we developed a site-selective Lewis acid-mediated transformation of pseudoglycals with various thiols for the synthesis of C-2 thioaryl glycosides. The substrate scope of the reaction was explored with various thiols having various functional groups on aromatic rings as well as with pseudoglycals obtained from different sugars. The compatibility and survival of various protecting groups on pseudoglycals and substituted thiols show tolerance under the reaction conditions. Finally, the potential synthetic utility of the synthesized compounds was demonstrated and also the late-stage modifications of various drugs and pharmaceuticals were also explored

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Section: Table 1 Optimization Of Reaction Conditions ...mentioning

confidence: 99%