Hepatitis C virus (HCV) seroprevalence, RNA detection, and genotype distribution across Florida, 2015–2018

Dickey, Brittney L.; Coghill, Anna E.; Rathwell, Julie; Reich, Richard R.; Vadaparampil, Susan T.; Christy, Shannon M.; Roetzheim, Richard G.; Shenkman, Elizabeth; Giuliano, Anna R.

doi:10.1016/j.ypmed.2022.107136

Cited by 1 publication

(1 citation statement)

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“…The demographics of the HCV in the sample was quite similar to the prevalence of HCV in the country with the most common genotype being 1a. 21 47.3% of the patients screened were identified in the F0 (no fibrosis) stage and 34.9% were in the early fibrosis stages. Only 18% of the patients were identified in the late fibrosis stages.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C Treatment in Persons Who Inject Drugs in a Medication Assisted Treatment Program: A Retrospective Review of an Integrated Model

Bobb¹,

Malayala²,

Ajayi³

et al. 2023

J Prim Care Community Health

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Background: Hepatitis C virus (HCV) infection is common among persons who inject drugs (PWID), mostly due to needle sharing. The number of new cases in PWID are steadily increasing despite the availability of effective treatments. The objective of this model is to increase uptake and compliance with HCV treatment. We developed a model to treat HCV and opioid use disorder simultaneously in a methadone maintenance program. Methods: Patients were screened on site for HCV at admission and then annually. Once HCV was positive, the genotypes and fibrosis scores were identified. Patients were enrolled into the treatment program after obtaining written consent. Patients either self-administered the medications at home or utilized a directly observed treatment (DOT). The sustained virologic response (SVR) was tested at 12 weeks posttreatment. We conducted a retrospective review of patients who received treatment and reviewed the demographic data, co-infections, medication administration, and SVR results at the end of study period. Results: One hundred ninety patients were identified as Hepatitis C positive. 88.9% (169 patients) received HCV treatment during the study period. 62.7% (106 patients) were male and 37.3% were female (63 patients). 62.7% of them (106 patients) completed HCV treatment by the end of study period. Out of them, 96.2% (102 patients) achieved SVR. 68.9% (73 patients) utilized DOT for medication administration. Conclusions: Our model successfully treated HCV in our patient population, who are otherwise deprived of resources and access to health care. Replicating this model is a potential strategy to reduce the disease burden and break the transmission cycle of HCV.

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Section: Discussionmentioning

confidence: 99%