Hepatitis C virus genotypes in north eastern Algeria: A retrospective study

Rouabhia, Samir

doi:10.4254/wjh.v5.i7.393

Cited by 22 publications

(18 citation statements)

References 23 publications

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“…Interestingly, it was observed that the predominant genotypes in males were 1b, 1c, 3a, 3b, 5a and 6a versus 1a, 2a, 2b and 4 in females ( Figure 2 ). In contrast to our observation, no gender wise variation was reported in HCV genotypes distribution in Algeria ( 17 ). However, in Libya, HCV genotype 1 was frequently found in males, whereas genotype 4 was frequently found in females ( 16 ).…”

Section: Discussioncontrasting

confidence: 99%

Geographic Distribution of Hepatitis C Virus Genotypes in Pakistan

et al. 2014

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Background:Distribution of Hepatitis C Virus (HCV) genotypes may be changed over time. Epidemiological Studies on distribution patterns of HCV genotypes in Pakistani population might assist for better treatment options and preventive strategies.Objectives:This study was conducted to determine distribution patterns of HCV genotypes in different geographical regions of Pakistan.Patients and Methods:In this cross-sectional study, 1818 randomly selected patients from different geographical regions of Pakistan, diagnosed with HCV infection by the third generation Enzyme Linked Immunosorbent Assay (ELISA), were included between April 2011 and December 2013. HCV RNA was detected in serum samples of patients by Reverse Transcription Polymerase Chain Reaction (RT- PCR) of the core region. Qualitative PCR was performed to determine viral load. HCV genotyping was performed by RT-nested PCR using type-specific primers of the core region. Frequency of different genotypes among patients was assessed according to gender, age and geographical region at the time of sampling.Results:Of 1818 HCV RNA positive samples, HCV genotypes PCR fragments were detected in 1552 (85.5%) samples. HCV genotype 3a was the predominant genotype (39.4%) followed by genotype 2a (24.93%). HCV genotype 3 was the predominant genotype in Punjab and Sindh regions, while genotype 2 was the most predominant genotype in Khyber Pakhtunkhwa region and the second predominant genotype after genotype 3 in Sindh region. The incidence of genotype 2a is increasing in our country with decrease in the incidence of genotype 3a. A higher incidence of HCV various genotypes were observed among male patients and those younger than 45 years.Conclusions:This study may facilitate treatment options and preventive strategies in Pakistan.

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Section: Discussioncontrasting

confidence: 99%

Geographic Distribution of Hepatitis C Virus Genotypes in Pakistan

et al. 2014

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“…Thus, our sample shows a clear predominance of subgenotype 1b (89%) followed by other types of subgenotypes. These results are in agreement with those of Debbeche et al (2013); Hmida et al (1995) and Rouabhia et al (2013) [16][17][18].…”

Section: Discussionsupporting

confidence: 93%

Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients

Guedri¹

2019

JHER

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Viral hepatitis C (HCV) is a major health problem that affects important number of people around the world, the emergence of new direct antiviral treatments is a real therapeutic revolution to days it allows the cure hepatitis C in the majority of patients, but these treatments is accompanied by numerous side effects. Sofosbuvir, Pegylated interferon and Ribavirin are the standard care for the treatment of chronic hepatitis C in Algeria. In this study, we are interesting to investigate hematological toxicity of Antiviral treatment in Algerian patients with chronic hepatitis C. We carried out a comparative study, which involved 300 men and women Algerian at different ages. The determination of the various Epidemiological, Hematological, biochemical (AST, ALT, Glycemia) and virological (Viral load) parameters was performed. The analysis of 300 data shows that the infection with hepatitis C affects the age group between (46 -65 years) with a percentage of 67% with a female predominance 82% and a clear predominance of genotype 1b with a percentage (89%), Dual therapy (Sofosbuvir + Ribavirin) and triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) induce a high hematological toxicity -Hemolytic anemia ( revealed by a decrease of the number of Red blood cell and Hemoglobin level, as well as the percentage of hematocrit and the increase of mean corpuscular volume that induced the increase of red blood cell masse and the expansion) -Thrombocytopenia (revealed by the decrease in the number of platelets ) and leukopenia (translated by the decrease in the number of White blood cells and lymphocytes as well as monocytes, and a very significant increase in granulocytes) whereas in monotherapy (Sofosbuvir) a low toxicity was noticed, the Patients how receiving triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) can be developing diabetes mellitus. Antiviral treatments were significantly induced hemolytic anemia, leucopenia and thrombopenia in Algerian patients with chronic hepatitis C.

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“…Our results were also similar to our neighboring country like India and in far away Asian country like Nepal and confirmed that most prevalent circulating in these countries was type 3a [ 41 ] but dissimilar to Americas, Europe and Japan where 1 and 2 are commonly circulating genotypes [ 42 ]. In North Africa and Middle East genotype 4 is prevalent while in Hong Kong and South Africa 5 and 6 genotypes were present [ 14 ].…”

Section: Discussionsupporting

confidence: 88%

Prevalence of hepatitis-C virus genotypes and potential transmission risks in Malakand Khyber Pakhtunkhwa, Pakistan

Nazir

Jan

Ali

et al. 2017

Virol J

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BackgroundHepatitis C virus (HCV) is a leading cause of chronic liver disease and frequently progresses towards liver cirrhosis and Hepatocellular Carcinoma (HCC). This study aimed to determine the prevalence of HCV genotypes and their association with possible transmission risks in the general population of Malakand Division.MethodologySum of 570 serum samples were collected during March 2011 to January 2012 from suspected patients visited to different hospitals of Malakand. The suspected sera were tested using qualitative PCR and were then subjected to molecular genotype specific assay. Quantitative PCR was also performed for determination of pre-treatment viral load in confirmed positive patients.ResultsOut of 570 serum samples 316 sera were seen positive while 254 sera were found negative using qualitative PCR. The positive samples were then subjected to genotyping assay out of 316, type-specific PCR fragments were seen in 271 sera while 45 samples were found untypable genotypes. Genotype 3a was seen as a predominant genotype (63.3%) with a standard error of ±2.7%. Cramer’s V statistic and Liklihood-Ratio statistical procedures are used to measure the strength and to test the association, respectively, between the dependent variable, genotype, and explanatory variables (e.g. gender, risk, age and area/districts). The dependent variable, genotype, is observed statistically significant association with variable risk factors. This implies that the genotype is highly dependent on how the patient was infected. In contrast, the other covariates, for example, gender, age, and district (area) no statistical significant association are observed. The association between gender-age indicates that the mean age of female was older by 10.5 ± 2.3 years with 95% confidence level using t-statistic.ConclusionIt was concluded from the present study that the predominant genotype was 3a in the infected population of Malakand. This study also highlights the high prevalence rate of untypable genotypes which an important issue of health care setup in Malakand and create complications in therapy of infected patients. Major mode of HCV transmission is multiple uses and re-uses of needles/injections.Trial registrationISRCTN ISRCTN73824458. Registered: 28 September 2014

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Hepatitis C virus genotypes in north eastern Algeria: A retrospective study

Cited by 22 publications

References 23 publications

Geographic Distribution of Hepatitis C Virus Genotypes in Pakistan

Geographic Distribution of Hepatitis C Virus Genotypes in Pakistan

Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients

Prevalence of hepatitis-C virus genotypes and potential transmission risks in Malakand Khyber Pakhtunkhwa, Pakistan

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