Hepatitis C virus genotypes: epidemiological and clinical associations

Kleter, Bernhard; Brouwer, JT; Nevens, Frederik; Doorn, L-J van; Elewaut, André; Versieck, Jacques; Michielsen, P.; Hautekèete, M.; Chamuleau, R. A. F. M.; Brenard, R.; Bourgeois, Nadine; Adler, Michaël; Quint, W. G. V.; Bronkhorst, C.M.; Heijtink, RA; Hop, W. C. J.; Fevery, Johan; Schalm, S. W.

doi:10.1111/j.1600-0676.1998.tb00124.x

Cited by 37 publications

(11 citation statements)

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“…The genotype 3a is the second most common genotype encountered in 23.2%. The prevalence of HCV genotypes in our investigation is mainly similar to reports of the HCV genotype distribution in other parts of Europe [6][7][8][9][10] . Our current results also confirm findings from Serbia previously published [11,12] .…”

Section: Discussionsupporting

confidence: 89%

“…Early investigations from the USA did not find an association between HCV genotypes and mode of transmission [18] . However, the investigators from Europe reported that patients with a history of blood transfusion were mostly infected with genotype 1b while intravenous drug abusers were infected with genotype 3a [7,9,10,[15][16][17]19,20] . Our results show that the genotype 3a is the most important predictive factor for IVDU that is in concordance with these reports.…”

Section: Discussionmentioning

confidence: 99%

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Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical significance

Svirtlih¹

2007

WJG

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical significance

Svirtlih¹

2007

WJG

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“…Occult HBV infection may influence this correlation, since the above-mentioned difference was not observed in the 37 patients with occult HBV infection. The association between genotype 1 and severe fibrosis, and between genotype non-1 and absent or mild fibrosis in chronic hepatitis C was first proposed in 1996 [Silini et al, 1996] and confirmed in subsequent articles [Bruno et al, 1997[Bruno et al, , 2007Mondelli and Silini, 1999;Osella et al, 2001], but this was disputed by the data of other authors [Mangia et al, 1997;Kleter et al, 1998;Bellentani et al, 1999]; common opinion on this topic is that there is no correlation between the HCV genotype and the degree of liver fibrosis. The data observed in this study population suggest that by removing the confounding effect of occult HBV infection, an association between genotype 1 and severe fibrosis and genotype non-1 and absent or mild fibrosis may become evident.…”

Section: Resultsmentioning

confidence: 99%

Diagnosis and clinical impact of occult hepatitis B infection in patients with biopsy proven chronic hepatitis C: A multicenter study

Sagnelli

Imparato

Coppola

et al. 2008

Journal of Medical Virology

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Occult hepatitis B virus (HBV) infection in patients with chronic hepatitis C has been found associated with severe liver damage, low response to interferon treatment and increased risk of developing HCC. However, doubts remain on its clinical impact and the sensitivity and specificity of its detection. HBV-DNA was sought by PCR in plasma, peripheral blood mononuclear cells (PBMCs) and liver compartments of 89 patients with biopsy proven chronic hepatitis C, using sets of primers for core ("c"), surface ("s"), and x ("x") regions of HBV genome. Occult HBV infection was defined by the presence of HBV-DNA in at least two different PCRs in at least one compartment. Occult HBV infection was detected in 37 (41.6%) of the 89 patients investigated. It was more frequent (80.8%) in 26 anti- HBs negative/anti-HBc positive patients than in 18 anti-HBs/anti-HBc positive (61.1%, P < 0.01) and 45 anti-HBs/anti-HBc negative (11.1%, P < 0.0001), and more frequently in liver (91.9%) than in PBMCs (62.2%) and plasma (32.4%). No association was found between occult HBV infection and the degree of liver necroinflammation and fibrosis. However, considering the 52 patients without occult HBV infection, 51.4% of 35 patients with genotype 1 and 5.9% of 17 with genotype non-1 showed severe fibrosis (P = 0.003); patients with occult HBV infection did not show such difference. Instead of seeking occult HBV infection in patients with chronic hepatitis C, both anti-HBs negative/anti-HBc positive and anti-HBs positive/anti-HBc positive, in plasma alone, more reliable information can also be obtained from the liver tissue and PBMCs.

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“…The relative proportions of infections by the different genotypes vary from country to country, and regions of the same country partly because of distribution of different at risk groups (58). The 1a genotype is associated with injection drug use in Western Europe (59). In Eastern Europe and Russia, genotype 1a was more prevalent in the general population prior to the epidemic of HCV among drug injectors, but 3a appears to have outstripped 1a in younger people and IDUs (60-63).…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C virus infection among drug injectors in St Petersburg, Russia: social and molecular epidemiology of an endemic infection

et al. 2009

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Aims-To understand the epidemiology and transmission patterns of hepatitis C virus (HCV), the predominant blood borne-pathogen infecting drug injectors (IDUs), in a part of the former Soviet Union.Design-Cross-sectional respondent driven sample of IDUs. Measurements-Participants were surveyed to collect demographic, medical, and both general and dyad specific drug injection and sexual behaviors. A blood sample was collected to detect antibodies to hepatitis C and to amplify viral RNA for molecular analysis. The molecular data, including genotypes, were analyzed spatially and linkage patterns were compared to the social linkages obtained by respondent driven sampling (RDS) for chains of respondents and among the injection dyads. Setting-St. Petersburg, RF Participants-387Findings-HCV infection was all but ubiquitous: 94.6% of IDUs were HCV-seropositive. Among the 208 viral sequences amplified, genotype 3a predominated (n=119, 56.9%) followed by 1b (n=61, 29.2%), and 1a (n=25, 11.9%). There was no significant clustering of genotypes spatially. Neither genotypes nor closely related sequences were clustered within RDS chains. Analysis of HCV sequences from dyads failed to find associations of genotype or sequence homology within pairs.Conclusions-Genotyping reveals that there have been at least five unique introductions of HCV genotypes into the IDU community in St. Petersburg. Analysis of prevalent infections does not appear to correlate with the social networks of IDUs, suggesting that simple approaches to link these networks to prevalent infections, rather than incident transmission, will not prove meaningful. On a more positive note, the majority of IDUs are infected with 3a genotype that is associated with sustained virologic response to antiviral therapy.

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Hepatitis C virus genotypes: epidemiological and clinical associations

Abstract: Priiirrd in Drnniurk . All rights rrsrrvrd Copj,righ/ 0 Miinksguurd I998 Liver ISSN 0106-9543 Hepatitis C virus EenotvDes: 0 4 A 0 4 epidermol .ogical aid c1i;;i' cal 0 b associations Kleter B, Brouwer JT, Nevens F, van Doorn L-J, Elewaut A, Versieck J,

Cited by 37 publications

References 24 publications

Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical significance

Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical significance

Diagnosis and clinical impact of occult hepatitis B infection in patients with biopsy proven chronic hepatitis C: A multicenter study

Hepatitis C virus infection among drug injectors in St Petersburg, Russia: social and molecular epidemiology of an endemic infection

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