Hepatitis C virus: Current steps toward elimination in Germany and barriers to reaching the 2030 goal

Sarrazin, Christoph; Boesecke, Christoph; Golsabahi-Broclawski, Solmaz; Moog, Gero; Negro, Francesco; Silaidos, Carmina; Patel, Polly; Lohmann, K; Spinner, Christoph D.; Walcher, Stephan; Wedemeyer, Heiner; Wörns, Marcus‐Alexander

doi:10.1002/hsr2.290

Cited by 11 publications

(9 citation statements)

References 36 publications

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“…On the other hand, an analysis of German screening tests shows that searching for new infections in risk groups makes it possible to identify 83% of all infected [ 27 ]. In Germany, the number of PWID had increased from 26.3% in 2014 to 43.1% in 2018 which constitutes 80% of newly identified HCV infections.…”

Section: Discussionmentioning

confidence: 99%

“…Areas and range of proposed actions in the eradication scenario[4,15,16,21,23,[25][26][27]32,33].Grassroots initiatives for screening tests.Hospitals, state and private centers, medical procedure units, medical labs and testing points, occupational medicine physicians-every patient and every visit (general population testing and risk groups-people with diabetes, inmates, PWID, men who have sex with other men, the homeless) funds in the system as an expected result of the lowering of the costs of financing the current system)Elimination of infectionInfection elimination level in the population-90-100%Percentage of those infected with HCV undergoing treatment-80-90%…”

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confidence: 99%

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Global Elimination of HCV—Why Is Poland Still So Far from the Goal?

Tronina,

Panczyk,

Zarębska-Michaluk

et al. 2023

Viruses

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Introduction: Eradication of HCV in the global population remains one of the greatest challenges faced by the WHO. An insufficient level of knowledge and the lack of a national screening test strategy are obstacles to HCV eradication. Aim: This work aimed to summarize surveys assessing risk factors and awareness of the respondents regarding the prevention and course of HCV infection. The summary also includes the most important European and global attempts at eliminating HCV. Materials and Methods: A cross-sectional, population-based study was conducted in the Mazowieckie district in Poland using anonymous surveys and conducted on people who willingly reported for a test. Results: In the study cohort of n = 7397 adults, there were 5412 women (73.16%). The analysis of the quota sample (n = 1303) reflected the actual proportions in the population of the Mazowieckie Voivodeship. Conclusions: Insufficient knowledge about HCV decreases the probability of higher detection of infections, fast diagnostics, and treatment. According to the WHO model, assuming a 90% detection rate and treatment of 80% of infected by 2030, and taking into account 120–150 thousand infected persons in Poland, the number of detections of HCV should be increased 4–5 times and all diagnosed persons should be offered antiviral treatment.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Global Elimination of HCV—Why Is Poland Still So Far from the Goal?

Tronina,

Panczyk,

Zarębska-Michaluk

et al. 2023

Viruses

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“…Prisoners have low security of ongoing medical care because of restricted personal liberty, but the relatively closed environment in prison makes it easier to conduct screening. In contrast, the difficulty of access is the main obstacle to screening the drug-addicted population ( 38 ). For the former, change in political will is needed, to ensure accessibility of hepatitis C screening in prisons.…”

Section: Out-of-hospital Screeningmentioning

confidence: 99%

Management of in- and out-of-hospital screening for hepatitis C

Zhou

Wang

et al. 2023

Front. Public Health

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Because of insidious progression and no significant clinical symptoms at early stage, chronic hepatitis C (CHC) is often diagnosed after the occurrence of cirrhosis and hepatocellular carcinoma. Highly effective and low drug resistance of direct-acting antiviral agents (DAAs) have enabled cure of CHC, encouraging the World Health Organization to propose a global viral hepatitis elimination program. To Date, vaccine for CHC is still under research. Therefore, reducing the source of infection is an important means of eliminating CHC other than cutting off the transmission route, which requires screening, diagnosing and treating as many patients in the population as possible. Hospital-based screening strategy have been found to be cost-effective in the management of CHC screening, as reported both nationally and internationally. Currently, China has issued In-hospital process for viral hepatitis C screening and management in China (Draft) in April, 2021, which provides a standardized implementation process and direction for in-hospital hepatitis C screening and treatment, but still requires medical institution to develop its own management process, taking into account its current situation and learning from domestic and international experience. In addition, screening for CHC outside the hospital among special populations, such as blood donors, pregnant women, homosexuals, intravenous drug users, prisoners, and residents in rural areas with scarce medical care resources, also requires attention and development of targeted and rational screening strategies. In this paper, we analyze and recommend the management of hepatitis C screening from both in-hospital and out-of-hospital perspectives, with the aim of contributing to the formulation of hepatitis C screening strategies.

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“…Die Voraussetzungen für eine tatsächliche Eliminierung von HCV sind daher grundsätzlich sehr gut, dennoch scheint sie in Deutschland vor allem mit Blick auf bestimmte Schlüsselgruppen unrealistisch [ 16 , 17 ]. Vor diesem Hintergrund ergibt sich auch die Frage nach der aktuellen Situation in Justizvollzugsanstalten (JVAen) in Deutschland.…”

Section: Hintergrundunclassified

Hepatitis C in Haftanstalten

Dichtl,

Jamin,

Stöver

et al. 2023

Bundesgesundheitsbl

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Zusammenfassung Hintergrund Trotz genereller Fortschritte bei der Hepatitis-C-Behandlung in Deutschland ist unklar, inwieweit dies auch für bestimmte Schlüsselgruppen, wie etwa Inhaftierte, gilt. Methoden In einer Kurzbefragung im Juni 2021 wurden die Justizministerien der Bundesländer über Datenerhebungs- und Diagnostikmethoden sowie die Prävalenz von Infektionen mit dem Hepatitis-C-Virus (HCV) und HCV-Behandlungen von Gefangenen in Deutschland befragt. Ergänzend dazu wurden Expert*inneninterviews zu Barrieren und bisher nicht genutzten Chancen der HCV-Behandlung in Haft geführt. Ergebnisse Es zeigt sich, dass keine vollständige und flächendeckende Datenerhebung innerhalb der Justizministerien vorliegt. Präventionsmaßnahmen wie Opiatsubstitutionstherapie in Haft sind in allen teilnehmenden Bundesländern verfügbar. Spezifischere Angebote und Maßnahmen (z. B. Rasierer, Spritzentausch) finden sich nur vereinzelt und sind teilweise kostenpflichtig. Die Expert*innen zeigen auf, dass die Behandlung innerhalb der Justizvollzugsanstalten zwar grundsätzlich dem Äquivalenzprinzip nachkommt, aber die Zielgruppe schwerer zu erreichen ist. Fazit Wichtig für eine erfolgreiche HCV-Eliminierung in Justizvollzugsanstalten sind eine flächendeckende Aufklärung und Beratung zur HCV-Behandlung, konsequente HCV-Testung und -Behandlung sowie Präventionsmaßnahmen zur Vermeidung von (Re)Infektionen.

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Hepatitis C virus: Current steps toward elimination in Germany and barriers to reaching the 2030 goal

Cited by 11 publications

References 36 publications

Global Elimination of HCV—Why Is Poland Still So Far from the Goal?

Global Elimination of HCV—Why Is Poland Still So Far from the Goal?

Management of in- and out-of-hospital screening for hepatitis C

Hepatitis C in Haftanstalten

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