Hepatitis C virus core protein stimulates hepatocyte growth: Correlation with upregulation of wnt-1 expression

Fukutomi, Takayoshi; Zhou, Yonghong; Kawai, Sadaaki; Eguchi, Hidetoshi; Wands, Jack R.; Li, Jisu

doi:10.1002/hep.20668

Cited by 147 publications

(126 citation statements)

References 27 publications

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“…Direct activation of the Wnt/β-catenin pathway was demonstrated in an in vitro model also separately for the core (C) protein of HCV [9,10,91]. HCVcore transfected Huh7 cells up-regulated Wnt-1 and WISP-2 transcription [91].…”

Section: Wnt/β-catenin Pathway In Hcv-associated Liver Carcinogenesismentioning

confidence: 89%

Alterations of Wnt/β-catenin signaling pathway in hepatocellular carcinomas associated with hepatitis C virus

Rogacki¹,

Kasprzak²,

Stępiński³

2015

pjp

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Section: Wnt/β-catenin Pathway In Hcv-associated Liver Carcinogenesismentioning

confidence: 89%

Alterations of Wnt/β-catenin signaling pathway in hepatocellular carcinomas associated with hepatitis C virus

Rogacki¹,

Kasprzak²,

Stępiński³

2015

pjp

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“…134 These cells demonstrated increased proliferation, DNA synthesis, and cell cycle progression. Proliferation was blocked by Wnt-1 siRNA.…”

Section: Hepatitis C Core Proteinmentioning

confidence: 99%

Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma

2006

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“…However, in other diseases, including arthritis (Manns et al 2006;Tanaka et al 2005) and viral hepatitis (Fukutomi et al 2005;Shin et al 2005), CCN2 and CCN5 are similarly expressed. CCN2 and CCN5 have opposite expression patterns in vascular SMC.…”

Section: Introductionmentioning

confidence: 99%

CCN5 expression in mammals

Jones

Gray

Oliveira

et al. 2007

J. Cell Commun. Signal.

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The six proteins of the CCN family have important roles in development, angiogenesis, cell motility, proliferation, and other fundamental cell processes. To date, CCN5 distribution in developing rodents and humans has not been mapped comprehensively. CCN5 strongly inhibits adult smooth muscle cell proliferation and motility. Its antiproliferative action predicts that CCN5 would not be present in developing tissues until the proliferation phase of tissue morphogenesis is complete. However, estrogen induces CCN5 expression in epithelial and smooth muscle cells, suggesting that CCN5 might be widely expressed in embryonic tissues exposed to high levels of estrogen.9-16 day murine embryos and fetuses and 3-7 month human fetal tissues were analyzed by immunohistochemistry. CCN5 was detected in nearly all developing tissues. CCN5 protein expression was initially present in most tissues, and at later times in development tissue-specific expression differences were observed. CCN5 expression was particularly strong in vascular tissues, cardiac muscle, bronchioles, myotendinous junctions, and intestinal smooth muscle and epithelium. CCN5 expression was initially absent in bone cartilaginous forms but was increasingly expressed during bone endochondral ossification. Widespread CCN5 mRNA expression was detected in GD14.5 mice. Although CCN2 and CCN5 protein expression patterns in some adult pathologic conditions are inversely expressed, this expression pattern was not found in developing mouse and human tissues. The widespread expression pattern of CCN5 in most embryonic and fetal tissues suggests a diverse range of functions for CCN5.

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Hepatitis C virus core protein stimulates hepatocyte growth: Correlation with upregulation of wnt-1 expression

Cited by 147 publications

References 27 publications

Alterations of Wnt/β-catenin signaling pathway in hepatocellular carcinomas associated with hepatitis C virus

Alterations of Wnt/β-catenin signaling pathway in hepatocellular carcinomas associated with hepatitis C virus

Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma

CCN5 expression in mammals

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