Hepatitis C virus-associated tubulointerstitial injury

Kasuno, Kenji; Ono, Takahiko; Matsumori, Akira; Nogaki, Fumiaki; Kusano, Hitoshi; Watanabe, Hidenobu; Yodoi, Junji; Muso, Eri

doi:10.1016/s0272-6386(03)00024-6

Cited by 68 publications

(41 citation statements)

References 26 publications

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“…This hypothesis was generated based on observations that hepatitis C is associated with some forms of glomerular disease [7][8][9][10][11] , that the co-existence of hepatitis C appears to increase the progression of CKD 14 , that viral particles or antigenicity is found in glomeruli and tubules of kidney biopsies 16,17 , and that CKD is very prevalent in areas with particularly high rates of hepatitis C infection 22 . Our results demonstrated no increased risk of having or developing CKD in patients who are hepatitis C positive in cross-sectional and longitudinal analyses after controlling for multiple other known risk factors for CKD.…”

Section: Discussionmentioning

confidence: 99%

“…More recently, two studies using data from the Third National Health and Nutrition Examination Survey (NHANES III) have found an increased risk of albuminuria in patients with hepatitis C 2, 12 , and another study found an increased risk of developing ESRD 13 . In addition, two studies have demonstrated that the progression of diabetic nephropathy is more rapid when patients are infected with hepatitis C 14, 15 , and other studies have found the presence of hepatitis C viral particles or antigens in glomeruli or tubules of kidney biopsies 16,17 . These data support that hepatitis C may also cause CKD, but this has not been clearly demonstrated.…”

Section: Introductionmentioning

confidence: 99%

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Association of Hepatitis C Virus Infection With Prevalence and Development of Kidney Disease

Moe

Pampalone

Ofner

et al. 2008

American Journal of Kidney Diseases

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Hepatitis C Virus Infection With Prevalence and Development of Kidney Disease

Moe

Pampalone

Ofner

et al. 2008

American Journal of Kidney Diseases

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“…The well-recognized renal manifestations of HCV are membranoproliferative glomerulonephritis (MPGN) (4 -7) and membranous nephropathy (5,8,9). Although glomerular (4 -6,8 -14) and tubulointerstitial (15,16) injuries have been described in association with HCV, the causal role of HCV is not clearly established in the majority of renal lesions that are associated with HCV infection. HCV infection has been associated with albuminuria (17,18), and HCV infection may have a broader impact on glomerular and tubulointerstitial function than currently recognized.…”

mentioning

confidence: 99%

Hepatitis C Virus Infection and the Prevalence of Renal Insufficiency

Dalrymple

Koepsell²,

Sampson³

et al. 2007

Clinical Journal of the American Society of Nephrology

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Background: Hepatitis C virus (HCV) is associated with pathologic changes in the kidney. However, the association between HCV and renal dysfunction is not well defined.Design, setting, participants, and measurements: This study estimated the prevalence of renal insufficiency among veterans who received care through the Veterans Affairs Puget Sound Health Care System. The study population consisted of veterans who underwent HCV antibody testing between January 1, 1999, and December 31, 2004, and had at least one primary care or medical subspecialty visit and at least one outpatient creatinine measurement within the 18 mo before antibody testing. Veterans were excluded when they had a history of chronic dialysis, creatinine >5 mg/dl, or renal transplantation. Study data were extracted from the electronic medical record. Renal insufficiency was defined as a creatinine level >1.5 mg/dl. Multivariate logistic regression was performed to estimate the risk for renal insufficiency associated with HCV. Among 25,782 eligible veterans, 1928 were HCV antibody positive and 23,854 were HCV antibody negative.Results: Although the proportion with renal insufficiency was lower for antibody-positive versus -negative veterans (4.8 versus 6.0%), after adjustment for age, race, gender, diabetes, and hypertension, HCV-positive veterans had a 40% higher odds for renal insufficiency (odds ratio 1.40; 95% confidence interval 1.11 to 1.76) as compared with HCV-negative veterans.Conclusions: HCV was associated with an increased prevalence of renal insufficiency.

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“…23,24 Viral RNA as well as viral proteins have been found in glomerular structures and in the tubular epithelial cells of HCV-infected patients. 25,26 Regardless of the tubulointerstitial injury associated with different glomerular lesions, HCV may lead to tubular injury in its own right.…”

mentioning

confidence: 99%

“…25,26 Regardless of the tubulointerstitial injury associated with different glomerular lesions, HCV may lead to tubular injury in its own right. 23 In the large EuroSida study, patients with HCV replication were at increased risk of developing chronic kidney disease. 27 Our results suggested that there was no increased risk of subclinical renal tubular injury in patients treated with PIs in comparison to those on EFV-based therapy.…”

mentioning

confidence: 99%

Urine Liver-Type Fatty Acid-Binding Protein and Kidney Injury Molecule-1 in HIV-Infected Patients Receiving Combined Antiretroviral Treatment Based on Tenofovir

Jabłonowska

Wójcik

Piekarska

2014

AIDS Research and Human Retroviruses

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The aim of this study was to determine the presence of kidney tubular damage in the absence of overt evidence of glomerular dysfunction (GFR > 60 ml/min without proteinuria) in HIV-infected patients receiving antiretroviral therapy. Urine kidney injury molecule-1 (KIM-1) and liver-type fatty acid-binding protein (L-FABP) levels were measured by ELISA and expressed as a ratio to creatinine. Sixty-six patients (median age 38 years) and 10 healthy controls (median age 35.5 years) were included in the study. Patients with chronic diseases such as diabetes, hypertension, heart disease, or kidney disease were excluded from the study. All patients received tenofovir/emtricitabine combined with one of three other components, namely efavirenz, atazanavir/norvir, or lopinavir/norvir. A lower concentration of L-FABP/creatinine was observed in HIV-infected as compared to healthy individuals ( p = 0.0353); KIM-1/creatinine was also lower in comparison with healthy controls but not statistically significantly. Patients receiving efavirenz had higher levels of L-FABP/creatinine in comparison to healthy controls ( p = 0.0039). Patients with anti-HCV had higher concentrations of L-FABP/creatinine as compared to the HIV-monoinfected individuals (not statistically significant) and to healthy subjects ( p = 0.0356). All four patients with L-FABP > 17.5 lg/g creatinine were HIV/HCV coinfected. On multivariate logistic regression urine L-FABP above 5.5 lg/g creatinine was independently associated with body weight (OR = 0.93 p = 0.039). This study suggests that HIV/HCV-coinfected patients with lower body weight treated with tenofovir may be at an increased risk of tubular dysfunction and should be monitored more closely. The use of protease inhibitors was not associated with an increased risk of tubular disorders.

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Hepatitis C virus-associated tubulointerstitial injury

Cited by 68 publications

References 26 publications

Association of Hepatitis C Virus Infection With Prevalence and Development of Kidney Disease

Association of Hepatitis C Virus Infection With Prevalence and Development of Kidney Disease

Hepatitis C Virus Infection and the Prevalence of Renal Insufficiency

Urine Liver-Type Fatty Acid-Binding Protein and Kidney Injury Molecule-1 in HIV-Infected Patients Receiving Combined Antiretroviral Treatment Based on Tenofovir

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