Hepatitis C virus associated skin manifestations in upper Egypt: Before and after direct acting antiviral treatment

Tawfik, Yasmin M; Hassany, Sahar M.; Badran, Aya Y.; El-Gazzar, Amira F; Alemam, Mohamed Farouk; Sayed, Doaa S.

doi:10.1111/dth.14365

Cited by 3 publications

(12 citation statements)

References 39 publications

(66 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two thousand articles were initially identified through database-searching on PubMed, Embase, Cochrane, Web of Science, and clinicaltrials.gov. Ultimately, 19 studies [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] meeting the prespecified inclusion criteria were selected (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…Clinical relapse was reported when there was a recurrence of purpura, arthralgia/arthritis, neuropathy, or nephropathy after CR or PR. Serological relapses were defined by cryoglobulins >1.5%, elevated rheumatoid factor (RF), or detectable complement 4 (C4) after the in- Out of the 19 included studies, the CryoVas response and relapse rates were provided in 14 studies and are summarized in Table 1 [14][15][16][17][18][19][20][21][22][23][24][25][26][27]. It includes data from 11 prospective cohort studies, 2 retrospective cohort studies, and 1 cross-sectional study.…”

Section: Hcv-related Cryovas Response With Daamentioning

confidence: 99%

“…Studies reported that approximately 74% of HCV-infected patients developed at least one extrahepatic manifestation during their lifetime, and 17% were attributed to dermatological conditions. Mixed cryoglobulinemia, lichen planus, and porphyria cutanea tarda are the most common dermatological complications of HCV infection [24].…”

Section: Dermatological Complicationsmentioning

confidence: 99%

“…According to an Egyptian study on 1000 patients with chronic hepatitis C by Tawfik et al [24], 369 patients presented with skin manifestations, and 286 of these 369 (77.5%) patients had cryoglobulinemia. In this and other reports, purpura was the most prevalent skin manifestation that presented in over 50% of patients with HCV-related CryoVas [19,27,28].…”

Section: Dermatological Complicationsmentioning

confidence: 99%

“…Overall, DAAs are superior to IFN-based regimens in treating extrahepatic manifestations of chronic hepatitis C, including dermatological conditions [20,22,24,26,27].…”

Section: Dermatological Complicationsmentioning

confidence: 99%

See 4 more Smart Citations

Persistence of Cryoglobulinemic Vasculitis after DAA Induced HCV Cure

Danishwar

Jamil

Khan

et al. 2022

JCM

View full text Add to dashboard Cite

Treatment with a direct acting antiviral (DAA) has revolutionized HCV therapy, as more than 95% of patients achieve a sustained virological response (SVR). Cryoglobulinemic vasculitis (CryoVas), however, can persist and recur after the HCV cure. In this systematic review, we include data from 19 studies that provided information on the persistence and recurrence of CryoVas after the HCV cure with DAAs. A complete clinical response (CR) was reported in 63.7% to 90.2% of the DAA-treated patients after achieving SVR. Relapse of CryoVas symptoms was reported in 4% to 18% of the patients. Neuropathy, nephropathy, and dermatological complications were the most common manifestations of CryoVas. B-cell clones persisted in 31–40% of the patients and could contribute to CryoVas relapse. INFL3-rs12979860, ARNTL-rs648122, RETN-rs1423096, and SERPINE1-rs6976053 were associated with a higher incidence of persistence and recurrence of CryoVas. Prospective multicenter studies with diverse patient populations are needed to validate these findings for the timely and effective management of this challenging condition.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Hcv-related Cryovas Response With Daamentioning

confidence: 99%

Section: Dermatological Complicationsmentioning

confidence: 99%

Section: Dermatological Complicationsmentioning

confidence: 99%

“…Overall, DAAs are superior to IFN-based regimens in treating extrahepatic manifestations of chronic hepatitis C, including dermatological conditions [20,22,24,26,27].…”

Section: Dermatological Complicationsmentioning

confidence: 99%

See 3 more Smart Citations

Persistence of Cryoglobulinemic Vasculitis after DAA Induced HCV Cure

Danishwar

Jamil

Khan

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

Viral Infections

Harwood,

Sterling

2024

Rook's Textbook of Dermatology

View full text Add to dashboard Cite

Viruses can cause disease in the skin or mucosa by direct infection or, via a systemic infection, produce secondary skin abnormalities. The chapter reviews the viruses associated with skin lesions, outlining the pathophysiology, the clinical features, diagnostic methods and the approaches to treatment. Primary skin infection following direct contact occurs with poxviruses, some herpesviruses and papillomaviruses leading to visible features which may be readily diagnostic. Less specific skin changes are seen with systemic infections, when infection is often via mucosae or inoculation, for example with parvovirus, measles or coronavirus and for these infections, diagnosis will usually involve body fluid analysis.

show abstract

Hepatitis C virus infection could be a risk factor for adult‐onset vitiligo in Egyptian patients: A cross‐sectional study

Fawzy

Hammad

Sharaf

et al. 2022

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Background Vitiligo is a common skin disorder resulting from the destruction of melanocytes. Hepatitis C virus (HCV) infection has been linked to a variety of extrahepatic manifestations, including skin diseases. Aim To measure the prevalence of HCV‐seroreactivity among vitiligo patients. Methods This cross‐sectional study included 108 vitiligo patients. Serum anti‐HCV antibodies were detected by chemiluminescence immunoassay. Results Eighteen patients (16.7%) out of 108 were HCV‐reactive; all of them had adult‐onset vitiligo. They represented approximately 34.6% of the total patients with adult‐onset vitiligo (52 patients). On the contrary, all patients with childhood‐onset vitiligo were HCV‐non‐reactive. Moreover, adult‐onset vitiligo was significantly associated with HCV‐seroreactivity (p < .001). Also, there was a significant difference between HCV‐reactive and HCV‐non‐reactive vitiligo patients regarding the age of patients and their ages at the onset of vitiligo (p < .001). Conclusions HCV may be the triggering factor for adult‐onset vitiligo, particularly in regions with a high prevalence of HCV. Therefore, patients with adult‐onset vitiligo, rather than childhood‐onset disease, should be screened for associated HCV infection in HCV‐endemic regions.

show abstract

Hepatitis C virus associated skin manifestations in upper Egypt: Before and after direct acting antiviral treatment

Cited by 3 publications

References 39 publications

Persistence of Cryoglobulinemic Vasculitis after DAA Induced HCV Cure

Persistence of Cryoglobulinemic Vasculitis after DAA Induced HCV Cure

Viral Infections

Hepatitis C virus infection could be a risk factor for adult‐onset vitiligo in Egyptian patients: A cross‐sectional study

Contact Info

Product

Resources

About