Hepatitis C Virus Antiviral Drug Resistance and Salvage Therapy Outcomes Across Australia
Dao Sen Wang,
Amy Phu,
Kristen McKee
et al.
Abstract:Background
Hepatitis C virus (HCV) infection can now be cured with well-tolerated direct acting antiviral (DAA) therapy. However, a potential barrier to HCV elimination is the emergence of resistance-associated substitutions (RASs) which reduce the efficacy of antiviral drugs, but real-world studies assessing the clinical impact of RASs are limited. Here, an analysis of the impact of RASs on retreatment outcomes for different salvage regimens in patients nationally who failed first-line DAA t… Show more
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