Hepatitis C Virus and Sjögren's Syndrome: Trigger or Mimic?

Ramos-Casals, Manuel; Muñoz, Sandra; Zeron, P. Brito

doi:10.1016/j.rdc.2008.08.007

Cited by 31 publications

(23 citation statements)

References 67 publications

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“…Accordingly, numerous HCV-associated SS cases have been reported. SS has been suggested as one of the systematic autoimmune diseases most closely associated with HCV [29]. A higher prevalence of SS was noted in patients with HCV infection (25.9%) than in those with HBV infection (3.4%) in a Japanese study [9].…”

Section: Discussionmentioning

confidence: 99%

Association of Sjögrens Syndrome in Patients with Chronic Hepatitis Virus Infection: A Population-Based Analysis

Yeh

Wang

et al. 2016

PLoS ONE

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ObjectiveThe association between Sjögren’s syndrome (SS) and chronic hepatitis virus infection is inconclusive. Hepatitis B (HBV) and hepatitis C virus (HCV) infections are highly prevalent in Taiwan. We used a population-based case-control study to evaluate the associations between SS and HBV and HCV infections.Materials and MethodsWe identified 9,629 SS patients without other concomitant autoimmune diseases and 38,516 sex- and age-matched controls without SS from the Taiwan National Health Insurance claims data between 2000 and 2011. We utilized multivariate logistic regression to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of the associations between SS and HBV and HCV infections. Sex- and age-specific (<55 and ≥55 years) risks of SS were evaluated.ResultsThe risk of SS was higher in patients with HCV than in those without chronic viral hepatitis (OR = 2.49, 95% CI = 2.16–2.86). Conversely, HBV infection was not associated with SS (OR = 1.10, 95% CI = 0.98–1.24). Younger HCV patients were at a higher risk for SS (<55 years: OR = 3.37, 95% CI = 2.62–4.35; ≥55 years: OR = 2.20, 95% CI = 1.84–2.62). Men with HCV were at a greater risk for SS (women: OR = 2.26, 95% CI = 1.94–2.63; men: OR = 4.22, 95% CI = 2.90–6.16). Only men with chronic HBV exhibited a higher risk of SS (OR = 1.61, 95% CI = 1.21–2.14).ConclusionHCV infection was associated with SS; however, HBV only associated with SS in men.

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Section: Discussionmentioning

confidence: 99%

Association of Sjögrens Syndrome in Patients with Chronic Hepatitis Virus Infection: A Population-Based Analysis

Yeh

Wang

et al. 2016

PLoS ONE

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“…For many pENL, there are distinctive clinicopathological features, sometimes associated with an underlying immunodeficiency syndrome (HIV/AIDS, organ transplant), autoimmune disorders [Sjogren syndrome, systemic lupus erythematosus (SLE), scleroderma, inflammatory bowel disease (IBD), dermatomyositis, Hashimoto thyroiditis, rheumatoid arthritis], infection [Helicobacter pylori, Campylobacter jejuni, Borelia burgdorferi, Chlamydia psittaci, Epstein Barr virus (EBV), Human T-lymphotropic virus1 (HTLV-1), Human herpes virus 8 (HHV-8), and Hepatitis C virus (HCV)] or a predilection to affect patients of certain ethnic origin (Bernatsky et al, 2006;Engels 2007;Ferry, 2008). HCV is considered as a virus with triple tissue tropism (hepatotropism, lymphotropism, and sialotropism) and this may explain the higher prevalence of sicca syndrome, cryoglobulinemia, and lymphoproliferative disorder (MALT lymphoma) in patients with chronic HCV infection (Ramos-Casals and Munoz, 2008).…”

Section: Introductionmentioning

confidence: 99%

Primary Extra Nodal Non Hodgkin Lymphoma: A 5 Year Retrospective Analysis

Padhi¹,

Paul²,

Challa³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…60 Hepatitis C patients also have abnormal objective tests for dry mouth and dry eyes. 62 Hepatitis C virus is sialotrophic and has been shown to infect and replicate in salivary gland tissue, including salivary gland epithelial cells. Nine of these 13 patients had clinical and laboratory markers for liver disease while the remaining four were asymptomatic with elevated transaminase levels.…”

Section: Environmental Factorsmentioning

confidence: 99%