Hepatitis C virus and lichen planus in Nigerians: any relationship?

Daramola, O O M; Fwacp, Mbbs; George, A. O.; Fmcp, Mbbs; Ogunbiyi, Adebola; Mbbs, Fmcp Fwacp

doi:10.1046/j.1365-4362.2002.01465.x

Cited by 51 publications

(39 citation statements)

References 13 publications

(29 reference statements)

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“…Recently, a more widespread and chronic viral disease, hepatitis C (HCV), has been implicated in triggering LP. While some studies of selected populations with LP have confirmed a significant association with HCV [3,6-9], other investigations have failed to document this finding [10-14]. This study was conducted to determine the frequency of hepatitis C in patients with LP at Razi hospital, in Tehran, Iran.…”

Section: Introductionmentioning

confidence: 99%

Lichen planus and Hepatitis C: a case-control study

et al. 2004

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BackgroundThe association of lichen planus with hepatitis C (HCV) has been widely reported in the literature. However, there are wide geographical variations in the reported prevalence of HCV infection in patients with lichen planus. This study was conducted to determine the frequency of hepatitis C in Iranian patients with lichen planus at Razi hospital, Tehran.MethodsDuring the years 1997 and 1998, 146 cases of lichen planus, 78 (53.1%) women and 69 (46.9%) men were diagnosed. They were diagnosed on the basis of the usual clinical features and, if necessary, typical histological findings. The patients were screened for the presence of anti-HCV antibodies by third generation ELISA and liver function tests. We used the results from screening of blood donors for anti HCV (carried out by Iranian Blood Transfusion Organization) for comparison as the control group.ResultsAnti-HCV antibodies were detected in seven cases (4.8%). This was significantly higher than that of the blood donors' antibodies (p < 0.001). The odds ratio was 50.37(21.45–112.24). A statistically significant association was demonstrated between erosive lichen planus and HCV infection. Liver function tests were not significantly different between HCV infected and non-infected patients.ConclusionHCV apears to have an etiologic role for lichen planus in Iranian patients. On the other hand, liver function tests are not good screening means for HCV infection.

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Section: Introductionmentioning

confidence: 99%

Lichen planus and Hepatitis C: a case-control study

et al. 2004

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“…17 In some areas of minimal HCV endemicity, such as the United Kingdom, France, the Netherlands, Germany, Scandinavia, Nepal, and Nigeria, patients with OLP have rates of HCV infection near 0. [18][19][20][21][22][23] No cases of HCV infection or liver abnormality were found in the United States. 24 Another way to look at this problem is to investigate the occurrence of OLP in anti-HCV-positive individuals, but few studies started with this population and, in most of these, 25-28 the prevalence of HCV infection did not seem to influence the rate of association with OLP, but eventual coinfection of HIV was never considered.…”

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confidence: 99%

Oral lichen planus, hepatitis C virus, and HIV: No association in a cohort study from an area of high hepatitis C virus endemicity

Campisi¹,

Fede²,

Craxı̀³

et al. 2004

Journal of the American Academy of Dermatology

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“…31 No presente estudo, não foi encontrada diferença quantitativa desta associação com o Líquen Plano, o que sugere que esta variável não foi relevante na metanálise. Em relação a idade, segundo Campisi et al, 20 a prevalência de LP é maior nos pacientes com idade acima de 60 anos, em relação aos pacientes na faixa etária entre 30 -39, do mesmo modo que a infeção pelo HCV é crescente na escala de idade.…”

Section: Discussionunclassified