Hepatitis C Virus and Atherosclerosis in Patients With Type 2 Diabetes

Fukui, Michiaki; Kitagawa, Yoshihiro; Nakamura, Naoto; Yoshikawa, Toshikazu

doi:10.1001/jama.289.10.1245-b

Cited by 72 publications

(46 citation statements)

References 5 publications

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“…Most controlled studies have suggested a significant association, the proportion of HCV-positive persons among diabetics being two-to seven-fold compared to controls [8,15,29,32] . The prevalence of HCV markers among patients with T2D reported by uncontrolled studies was also claimed to be higher than that observed in the general population taken as a reference [25,27,30] . However, the study by Sotiropoulos et al [26] reported a rather low HCV prevalence (1.65%), especially if one considers that a field survey in the Greek general population gave a HCV seroprevalence of 1.25% [34] .…”

Section: Association Between Hcv and T2dmentioning

confidence: 81%

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Hepatitis C virus and type 2 diabetes

Negro¹,

Alaei²

2009

WJG

143

118

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This review focuses on the relationship between h e p a t i t i s C v i r u s ( H C V ) i n fe c t i o n a n d g l u c o s e metabolism derangements. Cross-sectional and longitudinal studies have shown that the chronic HCV infection is associated with an increased risk of developing insulin resistance (IR) and type 2 diabetes (T2D). The direct effect of HCV on the insulin signaling has been analyzed in experimental models. Although currently available data should be considered as preliminary, HCV seems to affect glucose metabolism via mechanisms that involve cellular pathways that have been implicated in the host innate immune response. IR and T2D not only accelerate the histological and clinical progression of chronic hepatitis C, but also reduce the early and sustained virological response to interferonalpha-based therapy. Thus, a detailed knowledge of the mechanisms underlying the HCV-associated glucose metabolism derangements is warranted, in order to improve the clinical management of chronic hepatitis C patients.

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Section: Association Between Hcv and T2dmentioning

confidence: 81%

“…measuring the prevalence of HCV markers among populations of diabetic patients [8,15,[25][26][27][28][29][30][31][32][33] . Most controlled studies have suggested a significant association, the proportion of HCV-positive persons among diabetics being two-to seven-fold compared to controls [8,15,29,32] .…”

Section: Association Between Hcv and T2dmentioning

confidence: 99%

Hepatitis C virus and type 2 diabetes

Negro¹,

Alaei²

2009

WJG

143

118

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“…Several studies have found an increased rate of atherosclerosis in patients with HCV infection. 2,[7][8][9] In fact a recent metanalysis even concluded an increased risk of CAD in HCV-infected individuals. 15 We also noted that a significantly lower number of patients in the HCV group were receiving antiplatelet agents like aspirin and lipid-lowering agents such as statins potentially exacerbating coronary atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6] Reports of an increased risk [1][2][3] or an increase in measures of subclinical atherosclerosis have fueled continued interest to further explore any such associations. [7][8][9] One of the major drawbacks of the earlier negative studies was the lack of well-designed controls and failure to control for the risk factors associated with CAD.…”

mentioning

confidence: 99%

Higher Prevalence and More Severe Coronary Artery Disease in Hepatitis C Virus-infected Patients: A Case Control Study

Satapathy

Kim

Kataria

et al. 2013

Journal of Clinical and Experimental Hepatology

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Background: An association of Coronary artery disease (CAD) with hepatitis C (HCV) has been suggested, but definitive data are still lacking. Aim: Our study sought to estimate the prevalence and severity of CAD in HCV patients compared to with age-, sex-, and race-matched controls without HCV infection. Subjects and methods: 63 HCV-infected patients were compared with 63 age, race, and sex-matched controls without HCV infection undergoing coronary angiography for evaluation of CAD. CAD was defined as more than a 50% blockage in any of the proximal coronary arteries on angiogram. The severity of the stenosis was defined by the modified Reardon severity scoring system: <50% stenosis of the luminal diameter, 1 point; 50-74%, 2 points; 75-99%, 3 points; 100% or total obstruction, 4 points. The points for each lesion in the proximal coronary circulation were summed to give the score for severity. Results: A significantly higher prevalence of CAD was noted in the HCV population (69.8% vs. 47.6%, = 0.01). The combined Reardon's severity score in the HCV group was significantly higher compared to the controls (6.26 ± 5.39 vs. 2.6 ± 3.03, P < 0.0005). Additionally, significant multivessel CAD (>50% stenosis and $2 vessels involved) was also noted significantly more commonly in the HCV group compared to controls (57.1% vs. 15.9%, P < 0.0005). Conclusion: In this retrospective study the prevalence and severity of CAD was higher in HCV patients who were evaluated for CAD by angiogram compared with matched non-HCV patients. HCV-positive status is potentially a risk factor for CAD. ( J CLIN EXP HEPATOL 2013;3: 186-191)

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“…2,5 Based on results from the SMART study, a non suppressed HIV viral load appears to be an independent predictor of increased CHD risk. 30 Similarly, among those who are co-infected with HCV, several studies suggest that HCV may be associated with an increased risk of subclinical 31,32 or clinical atherosclerosis 33 and HIV-HCV coinfection may be associated with an increased risk of cardiovascular disease. 14 Whether less aggressive lipid management contributes to the increased risk of CHD among HIV-infected people, particularly those with higher viral loads or coinfection with hepatitis C, is not known.…”

Section: Discussionmentioning

confidence: 99%