Hepatitis C Virus Activates Bcl-2 and MMP-2 Expression through Multiple Cellular Signaling Pathways

Li, Y.; Zhang, Q.; Liu, Y.; 羅, 志偉; Liu, Kang; Qu, Jing; Liu, W.; Xia, Xueshan; Wu, Kailang; Wu, Jing

doi:10.1128/jvi.01136-12

Cited by 33 publications

(31 citation statements)

References 70 publications

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“…These results come in concordance Delladetsima et al and Ozaras et al who ascertained the interconnection between different apoptotic parameters and inflammation and fibrosis [5,7]. Supporting this theory is the evident Bcl2 expression in liver of cirrhotic patients with concealed presence in the liver of hepatitis C patients detected by [28][29][30][31]. This hypothesis was sourced to rationalize the high incidence of hepatocellular carcinoma in cirrhotic HCV patients supported by the anti-apoptotic/oncogenic probability of bcl-2 [29].…”

Section: Discussionsupporting

confidence: 86%

“…Supporting this theory is the evident Bcl2 expression in liver of cirrhotic patients with concealed presence in the liver of hepatitis C patients detected by [28][29][30][31]. This hypothesis was sourced to rationalize the high incidence of hepatocellular carcinoma in cirrhotic HCV patients supported by the anti-apoptotic/oncogenic probability of bcl-2 [29]. El-Bendary et al had studied apoptosis in HCV infection associated with bilharziasis spotting light on the presence of apoptotic (fas) and antiapoptotic (Bcl2) markers [32].…”

Section: Discussionmentioning

confidence: 86%

See 1 more Smart Citation

Hepatic Progenitor Cells and Cells Resistant to Apoptosis in Chronic HCV

Elsabaawy¹,

Abdelsameea²,

Abdallah³

et al. 2017

J Mol Biomark Diagn

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 86%

Hepatic Progenitor Cells and Cells Resistant to Apoptosis in Chronic HCV

Elsabaawy¹,

Abdelsameea²,

Abdallah³

et al. 2017

J Mol Biomark Diagn

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“…57,63 Induction of MMP-2 is significantly stimulated in the liver of HCV-infected patients. 64 Although it appears that MMP-9 and MMP-2 induction in fibrosis is the most prominent among MMPs, there are also other MMPs that are able to cleave collagen-IV and other basement membrane components. MMP-19 deficiency causes fibrosis exacerbation in chronic fibrosis models induced by CCL 4 application.…”

Section: Metalloproteinases In the Development Of Liver Fibrosismentioning

confidence: 99%

Metalloproteinases in liver fibrosis: current insights

Zbodakova¹,

Chalupský²,

Turečková³

et al. 2017

MNM

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Liver fibrosis is defined by excessive deposition of extracellular matrix. The fibrotic conditions result from the imbalance between synthesis and deposition of fibrous tissues and decomposition of these matrix proteins. This process can be reversed as a regular part of the healing process after hepatic damage or can become chronic. When the protein matrix synthesis predominates and the decomposition is suppressed, fibrosis will progress into irreversible cirrhosis or steatosis. Among the molecular players involved in fibrotic liver diseases, metalloproteinases of matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase (ADAM) families are critical in the development of liver fibrosis and its resolution. Previously, MMPs were recognized as extracellular matrix degrading enzymes. Currently, they are also known as mediators in a variety of processes related to immunity and tissue repair. In this article, we have reviewed the models of liver fibrosis and findings on MMPs and ADAMs in hepatic fibrosis conditions.

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“…Li et al, (2012) (18) suggested that MMPs expression is consistently observed to be upregulated by HCV. HCV NS4B protein activates STAT3 by enhancing its phosphorylation and translocation; thereby activating MMP-2 and Bcl-2 expression; a step that result in the regulation of cell transformation, apoptosis and possibly tumorigenesis as a consequence of HCV infection.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis C Virus as risk factor for development of hepatocellular carcinoma in Egypt: II-Enhancement role of matrix metalloproteinases-2 in dissemination of HCC

2017

AJOCRR

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Hepatitis C virus (HCV) infection is a major public health problem all over the world. Egypt has the highest prevalence of HCV worldwide (17-26%) with subsequent high morbidity from chronic liver disease, cirrhosis and hepatocellular carcinoma (HCC). Matrix metalloproteinase are proteolytic enzymes that play a role in the degradation of extracellular matrix (ECM) which is necessary for invasion and metastasis of tumor cells. The present work was designed to study the relationship between HCV infection and circulating MMP-2 level in chronic HCV patients (either without or with hepatic complication) and compared to that of non-HCV cirrhotic patients as well as healthy controls, in order to clarify the role of HCV in changing microenvironment and underlying mechanisms associated with dissemination of malignancy. The level of MMP-2 was estimated in sera collected at different stages of HCV infections as well as in ascetic fluids collected from those developing either HCC or cirrhosis. Statistical analysis of their results revealed that MMP-2 levels were significantly elevated in all patient groups as compared to healthy controls. The level of MMP-2 in HCV patients with HCC was significantly elevated when compared to other HCV patients. Meanwhile MMP-2 in ascetic fluids of cirrhotic patients were similar to that detected in their sera, while in HCC patients there were 2.4 times elevations in serum level of MMP-2 as compared to that in ascetic fluids. These results revealed that HCV infection is not only responsible for biochemical and hematological abnormalities recorded at chronic stages of infection but also creating a microenvironmental change by enhancing MMP-2 release, which effect on infected cell by obliging them to modify their phenotype in order to survive, thus increasing the invasion potential and facilitate tumor progression.

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Hepatitis C Virus Activates Bcl-2 and MMP-2 Expression through Multiple Cellular Signaling Pathways

Cited by 33 publications

References 70 publications

Hepatic Progenitor Cells and Cells Resistant to Apoptosis in Chronic HCV

Hepatic Progenitor Cells and Cells Resistant to Apoptosis in Chronic HCV

Metalloproteinases in liver fibrosis: current insights

Hepatitis C Virus as risk factor for development of hepatocellular carcinoma in Egypt: II-Enhancement role of matrix metalloproteinases-2 in dissemination of HCC

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