Hepatitis C virus: A rare manifestation - Remitting relapsing central and peripheral demyelination

Bezerra, Márcio Luiz Escórcio; Harumi, Juliana Arita; Shinosaki, Jullyanna Sabrysna Morais; Pedroso, José Luiz; Aquino, Camila C.; Souza, Larissa Teles de; Baiense, Robson Fantinato; Oliveira, Acary Souza Bullé

doi:10.4103/0028-3886.76889

Cited by 10 publications

(6 citation statements)

References 13 publications

(20 reference statements)

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“…Most peripheral neuropathy in patients with HCV infection is the axonal type of symmetrical sensorimotor neuropathy or multifocal mononeuropathy. Peripheral demyelinating neuropathy has also been rarely described, most often in cryoglobulin negative patients (13,14). The link between HCV and demyelinating neuropathies could be related to a virus-triggered immune-mediated process (15).…”

Section: Discussionmentioning

confidence: 99%

Acute Combined Central and Peripheral Demyelination Showing Anti-Aquaporin 4 Antibody Positivity

et al. 2012

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Neuromyelitis optica spectrum disorder (NMOSD) is characterized by optic neuritis or transverse myelitis with anti-aquaporin 4 (AQP4) antibodies (1). We herein present the case of a patient with NMOSD who also was affected with peripheral neuropathy. A 58-year-old woman developed gait disturbance and sensory impairment in the lower limbs. She exhibited longitudinally extensive transverse myelitis with anti-AQP4 antibodies. Nerve conduction studies showed demyelinating changes. Laboratory findings showed hepatitis-C virus (HCV) infection. Her peripheral neuropathy improved after immunotherapy. There have been no previous reports of NMO or NMOSD associated with neuropathy. The HCV infection or undetermined humoral factors other than the anti-AQP4 antibodies may have caused her peripheral neuropathy.

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Section: Discussionmentioning

confidence: 99%

Acute Combined Central and Peripheral Demyelination Showing Anti-Aquaporin 4 Antibody Positivity

et al. 2012

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“…In the relevant literature, symmetric sensorimotor PN of mostly the axonal type and mononeuropathy multiplex are reported in association with hepatitis C infection (22). However, in patients lacking cryoglobulin, demyelinating PN dominate (23,24).…”

Section: Discussionmentioning

confidence: 99%

“…Arch Neuropsychiatr 2016; 53:[23][24][25][26][27] Köşkderelioğlu et al Electrophysiological study in Hepatitis C infection…”

mentioning

confidence: 99%

Screening for Electrophysiological Abnormalities in Chronic Hepatitis C Infection: Peripheral Neuropathy and Optic Neuropathy

Köşkderelioğlu

Ortan

Arı

et al. 2016

Arch Neuropsychiatr

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Hepatitis C-related neurological abnormalities may occur both in the central and peripheral nervous system. Mononeuritis multiplex, sensorial axonal neuropathy, and multiple mononeuropathies are some of the presentations of the peripheral nervous system involvement. The mode of infection is considered to be via vasculitic mechanisms. In addition, optic neuropathy is a known complication of interferon treatment. Autoantibodies, cytokines, chemokines, and cryoglobulins are accused to play roles in the pathogenesis. In this study, we investigated the involvement of the peripheral nervous system and optic nerves in a group of patients with hepatitis C. The results were in favor of peripheral nerve injury of various types and optic neuropathy of the axonal type.

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“…In both cases, patients improved with steroid treatment. Mestre et al [88] and Bezerra et al [89] reported cases in which patients developed both peripheral and CNS demyelination. Moreover, the patient reported by Bezerra et al had relapsingremitting demyelination involving the brain and spinal cord, following a course like multiple sclerosis (MS).…”

Section: Central Nervous System Disorders With Hepatitis C Infectionmentioning

confidence: 98%

Neurological Complications of Hepatitis C Infection

McCarthy

Ortega

2012

Curr Neurol Neurosci Rep

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Though well-known as a cause of liver disease, Hepatitis C virus infection is emerging as a cause of a variety of peripheral and central nervous system disorders. The virus causes chronic persistent infection with complex immune responses in the majority of individuals. Viral infection may have the potential to generate neurological illness through direct infection of neural cells or through immune-mediated mechanisms, including enhancement of autoimmune responses. Moreover, the mainstay of antiviral treatment of hepatitis C infection, interferon-alpha, is itself associated with neurological morbidity. Thus neurologists are increasingly faced with diagnosing or even predicting a wide spectrum of neurological complications of hepatitis C infection and/or its treatment.

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Hepatitis C virus: A rare manifestation - Remitting relapsing central and peripheral demyelination

Cited by 10 publications

References 13 publications

Acute Combined Central and Peripheral Demyelination Showing Anti-Aquaporin 4 Antibody Positivity

Acute Combined Central and Peripheral Demyelination Showing Anti-Aquaporin 4 Antibody Positivity

Screening for Electrophysiological Abnormalities in Chronic Hepatitis C Infection: Peripheral Neuropathy and Optic Neuropathy

Neurological Complications of Hepatitis C Infection

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