Hepatitis C Virus

Simmonds, Peter; Mutimer, David

doi:10.1002/9780470688618.taw0260

Cited by 2 publications

(5 citation statements)

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“…Moreover, the modes of transmission of HBV, HCV and HIV are similar; hence, they are likely to be seen in the same patient. [9] The interactions are resulting from such co-infections often result in varied clinical presentations, increased severity and duration of CLD which ultimately affects the treatment culminating in an adverse outcome. [12,15,29] Anti-HIV was reactive for 7 (12.28%) patients.…”

Section: Discussionmentioning

confidence: 99%

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Pilot study of hepatitis b, c and human immunodeficiency viruses infections among patients with chronic liver diseases from north-east india attending a new tertiary care health set up at shillong

et al. 2017

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Background: Chronic liver diseases (CLD) are major public health concerns in North-Eastern India. Association of hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections in CLD patients result in atypical presentations with increased severity and duration of illness. Understanding of agent, host, clinical profiles and their co-relationship for better management and prevention of such diseases in the community are important challenges. Aims: To assess sero-prevalance of HBV, HCV, HIV and their co-infection/triple infection in CLD patients from North-East India. To determine risk factors predisposing to development of CLDs. To find out if any correlation exists between risk factors for CLDs and that of HBV/HCV/HIV infections. Materials And Methods: This study was conducted from December 2009 to June 2011 in North-Eastern Indira Gandhi Regional Institute of Health and Medical Sciences. Blood samples were collected from 57 clinically diagnosed CLD patients after obtaining Institutional ethical clearance. Detail clinical profile with relevant biochemical test results were recorded. Viral markers -hepatitis B surface antigen, hepatitis B e (HBe) antigen, anti-HBe and anti-HCV were assessed employing commercial ELISA kits. Specimens were subjected for detection and confirmation of HIV infection as per NACO Guidelines. Results: Male to female ratio was 1.85:1 with most cases in range of 31-50 years. HBV markers were detected in 35 (61.40%) and anti-HCV in 2 (3.5%) patients. Anti-HIV was reactive in 7 (12.28%) patients; 4 co-infected with HBV and 2 with HCV. Conclusion: HBV is still a major cause of CLD, followed by HCV in North-East India. Co-infection of HBV/HCV with HIV was low (7.14%) in comparison to rest of India. Confections of HIV with HBV/HCV in CLDs patients was observed to be major public health concern in terms of risk factors and transmission dynamics of these chronic diseases in North-East India.

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Section: Discussionmentioning

confidence: 99%

“…Approximately 20% of chronic HCV infection progress to cirrhosis with an increased risk for development of HCC. [9] Data from Europe indicate HCV prevalence as 0.1-6%. [4] Asian studies report anti-HCV reactivity in 8-64% of CLD patients.…”

Section: Introductionmentioning

confidence: 99%

Pilot study of hepatitis b, c and human immunodeficiency viruses infections among patients with chronic liver diseases from north-east india attending a new tertiary care health set up at shillong

et al. 2017

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“…By monitoring and strict enforcement of this law, transmission of HCV through blood transfusion could be reduced to a minimum. This has already been achieved in some western countries [ 3 ].…”

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confidence: 95%

“…Table 1 shows that the prevalence of HCV antibodies in HBD is 1.76%. Hepatitis C accounts for 70–80% post transfusion non A-non B hepatitis cases in centres where only hepatitis B free blood is transfused [ 3 ]. In India, screening of blood for anti HCV antibodies is mandatory since 2004 [ 4 ].…”

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confidence: 99%

“…This high prevalence seems to be the result of direct percutaneous exposure due to sharing of contaminated needles. It has been reported that the seroconversion rate in IDUs is 20% per year and long term IDUs are almost invariably HCV infected [ 3 ]. Among the HRSP group, the positivity was 2.72% and it showed insignificant difference (p > 0.05) from that observed in HBD (1.76%).…”

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confidence: 99%

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