Hepatitis C Viremia Persistently Suppressed by HAART

Spontaneous clearance of hepatitis C virus after liver transplantation in two patients coinfected with hepatitis C virus and human immunodeficiency virus

“…16,17 In addition, antiretroviral therapy used for HIV suppression may confer additional suppression of HCV, ultimately enabling HCV clearance. 18 The mechanism for spontaneous clearance of chronic HCV infection observed in our coinfected patients post-OLT, however, remains unclear. As the population of coinfected individuals requiring OLT increases, our ability to prospectively analyze the interaction between host and viral factors influencing HCV clearance will improve.…”

The role of triple infection with hepatitis B virus, hepatitis C virus, and human immunodeficiency virus (HIV) type-1 on CD4+ lymphocyte levels in the highly HIV infected population of North-Central Nigeria

“…We also record that, the rate of increase in CD4 + cells post-HAART does not change in HIV and hepatitis coinfection but HCV appears to hinder virological response to therapy. Although there have been case reports of clearance of HCV viraemia after initiation of HAART (Ranieri et al 2003), majority of available data indicates that HAART results in net increase in HCV viraemia (Chung et al 2002). We have recorded that 7.2% of individual do have triple coinfection with HIV/HBV/ HCV.…”

Spontaneous Clearance of Hepatitis C Virus in a Patient Co- Infected with Hepatitis C Virus and Human Immunodeciency Virus: a Case Report

“…Direct or indirect e ect of HAART on HCV replication has been proposed to play a role in spontaneous resolution of HCV infection [9,13]. Neau et al reported that serum HCV-RNA levels increased during the rst months of HIV treatment with protease inhibitors, and thus, HCV viral load suppression was likely due to host immune recovery from long-term HAART therapy [20].…”

“…However, spontaneous clearance of chronic HCV infection is rare. Few have described HCV clearance in association with cessation of immunosuppression, liver transplantation, other acute viral infections or change in HAART regimen [3][4][5][6][7][8][9][10][11][12][13]. To our knowledge, spontaneous HCV clearance in HIV/HCV patients with decompensated cirrhosis has not been reported in the literature.…”