Hepatitis C viraemia in recipients of Irish intravenous anti-D immunoglobulin

Power, Joan; Lawlor, Emer; Davidson, Fiona; Yap, P. L.; Kenny-Walsh, Elizabeth; Whelton, M. J.; Walsh, T.J.

doi:10.1016/s0140-6736(94)90679-3

Cited by 86 publications

(45 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Firstly, the pathways followed on natural sequence drift must be extremely constrained, and lead to substantial homoplasy and sequence convergence, which can be studied experimentally. For example, HCV variants infecting different individuals 20 yr after exposure to a shared source of genotype 1b infection (Power et al 1994) each provides independent examples of how HCV could have achieved their current divergence (4%) while maintaining RNA structure. Indeed, specific comparison of these sequences with those derived through computer-simulated neutral drift will provide novel insights into constraints operating in vivo, and, more mechanistically, how RNA structure is maintained during virus diversification.…”

Section: Evolutionary Implications Of Gorsmentioning

confidence: 99%

Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses: Implications for virus evolution and host persistence

Simmonds

Tuplin²,

Evans³

2004

RNA

193

226

View full text Add to dashboard Cite

Discrete RNA secondary and higher-order structures, typically local in extent, play a fundamental role in RNA virus replication. Using new bioinformatics analysis methods, we have identified genome-scale ordered RNA structure (GORS) in many genera and families of positive-strand animal and plant RNA viruses. There was remarkably variability between genera that possess this characteristic; for example, hepaciviruses in the family Flaviviridae show evidence for extensive internal base-pairing throughout their coding sequences that was absent in both the related pestivirus and flavivirus genera. Similar genus-associated variability was observed in the Picornaviridae, the Caliciviridae, and many plant virus families. The similarity in replication strategies between genera in each of these families rules out a role for GORS in a fundamentally conserved aspect of this aspect of the virus life cycle. However, in the Picornaviridae, Flaviviridae, and Caliciviridae, the existence of GORS correlated strongly with the ability of each genus to persist in their natural hosts. This raises the intriguing possibility of a role for GORS in the modulation of innate intracellular defense mechanisms (and secondarily, the acquired immune system) triggered by doublestranded RNA, analogous in function to the expression of structured RNA transcripts by large DNA viruses. Irrespective of function, the observed evolutionary conservation of GORS in many viruses imposes a considerable constraint on genome plasticity and the consequent narrowing of sequence space in which neutral drift can occur. These findings potentially reconcile the rapid evolution of RNA viruses over short periods with the documented examples of extreme conservatism evident from their intimate coevolution with their hosts.

show abstract

Section: Evolutionary Implications Of Gorsmentioning

confidence: 99%

Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses: Implications for virus evolution and host persistence

Simmonds

Tuplin²,

Evans³

2004

RNA

193

226

View full text Add to dashboard Cite

show abstract

“…Crowe and colleagues 150 and Power and colleagues 151 followed up 232 women 17 years after inoculation. Of these, 70% had no symptoms, and the main symptom in the rest was fatigue.…”

Section: Infection From Contaminated Blood Antirhesus Immunisationmentioning

confidence: 99%

Pegylated interferon alpha-2a and -2b in combination with ribavirin in the treatment of chronic hepatitis C: a systematic review and economic evaluation

Shepherd

Brodin²,

Cave³

et al. 2004

Health Technol Assess

191

133

View full text Add to dashboard Cite

Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTA Declared competing interests of authors:John Gabbay is Director of the NCCHTA, but is not directly involved in setting research agendas. He is also a member of the editorial board for Health Technology Assessment, although was not involved in the editorial process for this report. JG is a member of the consumer involvement steering group at the NCCHTA and also is a member of INVOLVE, which promotes public involvement in the NHS, public health and social care research. Published October 2004This report should be referenced as follows: NHS R&D HTA ProgrammeT he research findings from the NHS R&D Health Technology Assessment (HTA) Programme directly influence key decision-making bodies such as the National Institute for Clinical Excellence (NICE) and the National Screening Committee (NSC) who rely on HTA outputs to help raise standards of care. HTA findings also help to improve the quality of the service in the NHS indirectly in that they form a key component of the 'National Knowledge Service' that is being developed to improve the evidence of clinical practice throughout the NHS.The HTA Programme was set up in 1993. Its role is to ensure that high-quality research information on the costs, effectiveness...

show abstract

“…The degree of diversity of type lb sequences is around 9 % over the complete genome, which dates the start of its dissemination to relatively recent times, perhaps over the last 40-50 years. How this genotype was transmitted remains unclear, although examples are known of type lb transmission to large sections of particular populations through the use of contaminated blood products (Hohne et al, 1994;Power et aL, 1994). Similarly, the close relatedness of type 3a isolates suggests more recent spread to a range of Western countries, in this case possibly through its association with intravenous drug abuse.…”

Section: Endemic and Epidemic Spread Of Hcvmentioning

confidence: 99%

Investigation of the pattern of hepatitis C virus sequence diversity in different geographical regions: implications for virus classification

Mellor

Holmes

Jarvis

et al. 1995

Journal of General Virology

241

204

View full text Add to dashboard Cite

Hepatitis C viraemia in recipients of Irish intravenous anti-D immunoglobulin

Cited by 86 publications

References 4 publications

Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses: Implications for virus evolution and host persistence

Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses: Implications for virus evolution and host persistence

Pegylated interferon alpha-2a and -2b in combination with ribavirin in the treatment of chronic hepatitis C: a systematic review and economic evaluation

Investigation of the pattern of hepatitis C virus sequence diversity in different geographical regions: implications for virus classification

Contact Info

Product

Resources

About