Hepatitis C infection increases the risk of new-onset diabetes after transplantation in liver allograft recipients

Soule, Jordana L.; Olyaei, Ali J.; Boslaugh, Tobin A.; Busch, Ann M. Herbage; Schwartz, Jonathan M.; Morehouse, Samuel H.; Ham, J. M.; Orloff, Susan L.

doi:10.1016/j.amjsurg.2005.01.033

Cited by 38 publications

(25 citation statements)

References 30 publications

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“…Therefore, we cannot establish the diabetic population as a group at high risk for HCV infection. Our findings did not confirm other studies that have reported increased HCV seroprevalence in patients with diabetes [10,[22][23][24][25][26] . In a case-control study conducted in the USA, 4.2% of 594 patients in a cohort with diabetes were found to be infected with HCV compared with 1.6% of control patients (377 patients with thyroid diseases) [27] .…”

Section: Discussioncontrasting

confidence: 56%

Association of hepatitis C virus infection and diabetes in central Tunisia

Kaabia¹,

Jazia²,

Slim³

et al. 2009

WJG

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AIM:To investigate hepatitis C virus (HCV) seropreva lence in Tunisian patients with diabetes mellitus and in a control group. METHODS:A crosssectional study was conducted to determine the HCV seroprevalence in 1269 patients with diabetes (452 male, 817 female) and 1315 non diabetic patients, attending health centers in Sousse, Tunisia. HCV screening was performed in both groups using a fourthgeneration enzyme immunoassay. RESULTS:In the diabetic group, 17 (1.3%) were found to be HCVinfected compared with eight (0.6%) in the control group, although the difference was not significant (P = 0.057). Quantitative PCR was performed in 20 patients. Eleven patients were positive and showed HCV genotype 1b in all cases. CONCLUSION:Frequency of HCV antibodies was low in patients with diabetes and in the control group in central Tunisia, with no significant difference between the groups.

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Section: Discussioncontrasting

confidence: 56%

Association of hepatitis C virus infection and diabetes in central Tunisia

Kaabia¹,

Jazia²,

Slim³

et al. 2009

WJG

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“…These data were repeatedly confirmed by later studies [43][44][45][46][47][48][49] , with one exception from the [University of California, Los Angeles (UCLA)] series, in which the lack of association may have been a consequence of the excess representation of HCVpositive patients [50] . Several predisposing factors were identified across the studies: impaired fasting glucose and a maximum lifetime BMI over 25 kg/m 2 [49] , age and male gender [48] , serum HCV RNA level after LT [51] , and use of tacrolimus [45] or steroid boluses [43] . On the other hand, use of cyclosporine [49] and rapid discontinuation of steroids [52] seem to reduce the incidence of T2D among HCV-positive persons.…”

Section: Association Between Hcv and T2dsupporting

confidence: 62%

Hepatitis C virus and type 2 diabetes

Negro¹,

Alaei²

2009

WJG

143

118

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This review focuses on the relationship between h e p a t i t i s C v i r u s ( H C V ) i n fe c t i o n a n d g l u c o s e metabolism derangements. Cross-sectional and longitudinal studies have shown that the chronic HCV infection is associated with an increased risk of developing insulin resistance (IR) and type 2 diabetes (T2D). The direct effect of HCV on the insulin signaling has been analyzed in experimental models. Although currently available data should be considered as preliminary, HCV seems to affect glucose metabolism via mechanisms that involve cellular pathways that have been implicated in the host innate immune response. IR and T2D not only accelerate the histological and clinical progression of chronic hepatitis C, but also reduce the early and sustained virological response to interferonalpha-based therapy. Thus, a detailed knowledge of the mechanisms underlying the HCV-associated glucose metabolism derangements is warranted, in order to improve the clinical management of chronic hepatitis C patients.

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“…Older patients and those with HCV-positive serology at transplantation were at risk of developing impaired glucose metabolism, as already documented in the literature (10). In a retrospective analysis, Soule et al (24) found a significant difference in the development of NODM in the HCV-positive group in liver transplantation as the result of a greater fasting insulin and high insulin resistance, with no difference in ␤-cell function or hepatic insulin extraction (25). We have found no such differences.…”

Section: Discussionmentioning

confidence: 52%