Hepatitis C infection and renal cell carcinoma: A systematic review and meta-analysis

Abstract

AIMTo investigate the association between hepatitis C virus (HCV) infection and risk of renal cell carcinoma (RCC).METHODSA literature search was performed from inception until February 2016. Studies that reported relative risks, odd ratios, hazard ratios or standardized incidence ratio comparing the risk of RCC among HCV-infected participants vs those without HCV infection were included. Participants without HCV infection were used as comparators. Pooled odds ratios and 95%CI were calculated using a random-effect, generic inverse variance method.RESULTSSeven observational studies were with 196826 patients were included in the analysis to assess the risk of RCC in patients with HCV. A significantly increased risk of RCC among participants with HCV infection was found with a pooled RR of 1.86 (95%CI: 1.11-3.11). The association between RCC and HCV was marginally insignificant after a sensitivity analysis limited only to studies with adjusted analysis, with a pooled RR of 1.50 (95%CI: 0.93-2.42).CONCLUSIONOur study demonstrated a potential association between HCV infection and RCC. Further studies of RCC surveillance in patients with HCV are required.

Epstein-Barr Virus and Human Adenovirus Viremia in Renal Tumors Is Associated with Histological Features of Malignancy

“…Third, the selection of tested viruses was subjective and does not rule out the importance of other viral infections in renal malignancies. Until now, the possible association between renal carcinogenesis and HPV infection [ 8 ] or hepatitis C virus infection [ 45 ] was suggested.…”

Hepatitis C virus and risk of extrahepatic malignancies: a case-control study

“…Several studies have investigated the association between HCV infection and breast, thyroid, kidney, and pancreatic cancers in other countries 18,33–35 . Bruno et al .…”

“…In 2016, a meta-analysis by Wijarnpreecha et al . 35 reported a significantly increased risk of kidney cancer among participants with HCV infection, with a RR of 1.86 (95% CI: 1.11–3.11). A major limitation in the meta-analysis by Wijarnpreecha et al .…”

Association between coffee consumption and risk of renal cell carcinoma: a meta‐analysis

“…However, RCC‐related mortality rates have been falling only minimally at an average of 0.7% annually over 2004–2013 . Although the previous studies demonstrated the risk factors of RCC, the exact pathogenesis of RCC remains unclear . As kidneys play an important role in water and electrolyte homeostasis, it is hypothesised that the risk of RCC may be a consequence of the quantity and type of beverages consumed despite the anticarcinogenic property as discussed.…”