Hepatitis C in nonobese nondiabetic patients: Insulin resistance and the metabolic syndrome make a difference

Crişan, Dana; Radu, Corina; Suciu, A; Leach, N.; Ştefănescu, Horia; Avram, Lucreția; Crişan, Nicolae; Grigorescu, Mircea

doi:10.1111/jvh.12610

Cited by 2 publications

(3 citation statements)

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“…According to Crisan et al, the presence of the G allele either homozygous GG or heterozygous CG strongly correlated with steatosis and fibrosis, while genotype C appears to be inversely correlated with these variables (19). This finding is also confirmed by Romeo et al, who reported a significantly 2-fold increase in the risk of developing NAFLD and progression in the presence of adiponutrin allele G (9).…”

Section: Discussionmentioning

confidence: 71%

“…It was also reported that the PNPLA3 G allele is an independent predictor for severe (S2-S3) steatosis and significantly associated with advanced (F3 -F4) fibrosis (19). A meta-analysis of five studies and more than 2000 patients showed that the G allele was a predictor for severe steatosis and fibrosis, especially in Caucasian populations (20).…”

Section: Discussionmentioning

confidence: 93%

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The Correlation between Single Nucleotide Polymorphism of MBOAT7 and PNPLA3 Genes to The Degree of Hepatic Fibrosis in HCV Patients: An Experience from Egypt

Youssef

Abbas

Aly

et al. 2020

Journal of Bioscience and Applied Research

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Objectives: To detect the correlation between the single nucleotide polymorphisms (SNPs) in MBOAT7 and PNPLA3 genes and hepatic fibrosis in hepatitis C virus (HCV) Egyptian patients, and to highlight the additive effect, if any, of MBOAT7 on the correlation of PNPLA3 polymorphism with liver fibrosis in HCV patients from Egypt. Methods: In this cross-sectional study, we recruited treatment-naïve patients with chronic HCV. The rs738409 (PNPLA3) and rs641738 (MBOAT7) polymorphisms were assessed by Real-Time PCR. We utilized the METAVIR-Score to classify the degree of hepatic fibrosis and necroinflammatory activity.Results: A total of 93 patients (mean age 42.72 ± 10.46; males = 49.5%) were included. Our analysis showed that 10.8% of the patients had GG genotype of the PNPLA3 gene and 46.2% had TT genotype of the MBOAT7 gene.Compared to combined CC and GC genotypes, carriers of GG genotype in the PNPLA3 gene were more likely to be males (p =0.041), have higher fibrosis grade (p =0.043), have higher serum creatinine (p=0.036), higher TSH (p =0.017) and higher viral load (p =0.045). Notably, we found a significant association between TT genotype in MBOAT7 and advanced fibrosis only (but not with necroinflammation (p >0.05). Our multivariate analysis showed that the GG genotype in the PNPLA3 gene and TT genotype in the MBOAT7 gene were independent predictors of advanced fibrosis. Conclusion: PNPLA3 GG genotype and MBOAT7 TT genotype are independent predictors for hepatic fibrosis, and thus might be linked to faster disease progression.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 93%

The Correlation between Single Nucleotide Polymorphism of MBOAT7 and PNPLA3 Genes to The Degree of Hepatic Fibrosis in HCV Patients: An Experience from Egypt

Youssef

Abbas

Aly

et al. 2020

Journal of Bioscience and Applied Research

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“…The viral RNA in the serum was low-loaded (data not registered). It has been noted that with the viral load in viremia, the IP-10 level decreases [13], [14].…”

Section: Discussionmentioning

confidence: 99%

The Estimate of Interferon-inducible Protein-10 and Interferon-γ in Hemodialysis Patients with Chronic HCV

Altobje

Al-Rrassam

2021

Open Access Maced J Med Sci

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BACKGROUND: Due to the rise in the number of deaths, the hepatitis C virus remains a public health issue worldwide. During the recovery period, cytokines are known as indicators of chronic liver infection. AIM: In this study, immunological parameters were measured and calculated in chronic hemodialysis patients after more than 6 months of drug administration. METHODS: We have picked 60 patients with hemodialysis who are anti-HCV positive. ELISA and the calculation of alkaline phosphatase (ALP) were used to evaluate IP-10 and IFN-γ. RESULTS: A substantial association between variables and infected cases was found. No worth was considered for genders or age categories. CONCLUSIONS: The serum IP-10 level can be a warning primarily for patients who have taken a variety of prescriptions intermittently. In both the RPT and RST cohorts, IFN-γ serum levels are usually elevated. Serum level ALP is not a particular chronic HCV predictor.

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Hepatitis C in nonobese nondiabetic patients: Insulin resistance and the metabolic syndrome make a difference

Cited by 2 publications

References 4 publications

The Correlation between Single Nucleotide Polymorphism of MBOAT7 and PNPLA3 Genes to The Degree of Hepatic Fibrosis in HCV Patients: An Experience from Egypt

The Correlation between Single Nucleotide Polymorphism of MBOAT7 and PNPLA3 Genes to The Degree of Hepatic Fibrosis in HCV Patients: An Experience from Egypt

The Estimate of Interferon-inducible Protein-10 and Interferon-γ in Hemodialysis Patients with Chronic HCV

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