Hepatitis C and history of FVIII inhibitor development in a long‐term cohort of Brazilian patients with haemophilia A

Martins, Marina Lobato; Chaves, Daniel Gonçalves; Silva-Malta, Maria Clara Fernandes da; Bolina-Santos, Eduarda; Barbosa-Stancioli, Edel Figueiredo; Carmo, Ricardo Andrade

doi:10.1111/hae.13944

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…We previously analyzed 565 hemophilia A patients from this same cohort and described that HCV was one of the factors that were independently associated with a history of inhibitor, besides severe hemophilia and only previous exposition to fresh frozen plasma. 16 In addition, anti-HCV reactivity was also strongly associated with low inhibitor levels (OR = 12.6), 16 which was again verified in the present study.…”

Section: Discussionsupporting

confidence: 84%

HCV infection in hemophilia A patients is associated with altered cytokines and chemokines profile and might modulate the levels of FVIII inhibitor

Bolina-Santos

Chaves

Silva-Malta

et al. 2021

Journal of Medical Virology

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Prevalence of hepatitis C virus (HCV) is high in hemophilia A patients and the development of FVIII inhibitor is another challenge in the management of these individuals. The influence of HCV infection in the occurrence of inhibitors was investigated by the comparison of clinical and laboratory data from noninfected (NI, n = 96) and chronically HCV-infected (HCV, n = 58) hemophilia A patients. Concentrations of plasmatic cytokines (IL-2, IL-4, IL-6, IL-10, TNF, IFN-γ, and IL-17A) and chemokines (CCL2, CCL5, CXCL8, CXCL9, and CXCL10) were quantified from

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Section: Discussionsupporting

confidence: 84%

HCV infection in hemophilia A patients is associated with altered cytokines and chemokines profile and might modulate the levels of FVIII inhibitor

Bolina-Santos

Chaves

Silva-Malta

et al. 2021

Journal of Medical Virology

Self Cite

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show abstract

“…It has been found that patients who are HCV-positive with factor VIII inhibitors have a complex immune profile characterized by higher levels of pro-inflammatory and anti-inflammatory cytokines compared to those who are not [ 4 , 5 ]. The cure rate of chronic hepatitis C has reached 90% with DAA therapy [ 6 ].…”

Section: To the Editormentioning

confidence: 99%

Does Treatment of Hepatitis C Reduce The Need For Factor Replacement in Hemophilia A?

Atay¹,

Türkoğlu²,

Kelkitli³

2022

Tjh

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Epidemiology, patient journey and unmet needs related to hemophilia in Brazil: a scoping review with evidence map

Schneider,

de Araujo,

Godoy dos Santos

et al. 2024

Hematology, Transfusion and Cell Therapy

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Hepatitis C and history of FVIII inhibitor development in a long‐term cohort of Brazilian patients with haemophilia A

Cited by 3 publications

References 11 publications

HCV infection in hemophilia A patients is associated with altered cytokines and chemokines profile and might modulate the levels of FVIII inhibitor

HCV infection in hemophilia A patients is associated with altered cytokines and chemokines profile and might modulate the levels of FVIII inhibitor

Does Treatment of Hepatitis C Reduce The Need For Factor Replacement in Hemophilia A?

Epidemiology, patient journey and unmet needs related to hemophilia in Brazil: a scoping review with evidence map

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