Hepatitis C and hepatocellular carcinoma in Latin America: Elimination as a path to cancer prevention

Goble, Spencer; Mattos, Angelo Z.; Mendizabal, Manuel; Debes, Jose D.

doi:10.1016/j.aohep.2023.101149

Cited by 1 publication

(1 citation statement)

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“…This highlights the critical importance of seeking out new medicines, with a focus on developing more reliable markers for HCC early diagnosis, treatment, and prognosis. Moreover, hepatitis has been considered as a factor in HCC (6,7), and therefore, the factors in hepatitis should be understood (8,9).…”

Section: Introduction 1background Of Hepatocellular Carcinomamentioning

confidence: 99%

Exploring non-coding RNA mechanisms in hepatocellular carcinoma: implications for therapy and prognosis

Tian,

Zhang,

Liu

et al. 2024

Front. Immunol.

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Hepatocellular carcinoma (HCC) is a significant contributor to cancer-related deaths in the world. The development and progression of HCC are closely correlated with the abnormal regulation of non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). Important biological pathways in cancer biology, such as cell proliferation, death, and metastasis, are impacted by these ncRNAs, which modulate gene expression. The abnormal expression of non-coding RNAs in HCC raises the possibility that they could be applied as new biomarkers for diagnosis, prognosis, and treatment targets. Furthermore, by controlling the expression of cancer-related genes, miRNAs can function as either tumor suppressors or oncogenes. On the other hand, lncRNAs play a role in the advancement of cancer by interacting with other molecules within the cell, which, in turn, affects processes such as chromatin remodeling, transcription, and post-transcriptional processes. The importance of ncRNA-driven regulatory systems in HCC is being highlighted by current research, which sheds light on tumor behavior and therapy response. This research highlights the great potential of ncRNAs to improve patient outcomes in this difficult disease landscape by augmenting the present methods of HCC care through the use of precision medicine approaches.

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Section: Introduction 1background Of Hepatocellular Carcinomamentioning

confidence: 99%