Hepatitis B virus vaccination in children with steroid sensitive nephrotic syndrome: Immunogenicity and safety?

Yıldız, Nurdan; Sever, Lale; Kasapçopur, Özgür; Çullu, Fügen; Arısoy, Nı̇l; Çalışkan, Salim

doi:10.1016/j.vaccine.2013.05.004

Cited by 29 publications

(25 citation statements)

References 18 publications

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“…It was suggested that the decision to administer the meningococcal C conjugate vaccine should be carefully considered in children with SSNS. Yildiz et al [ 9 ] suggested that patients with SSNS in hepatitis B virus (HBV) endemic regions should receive HBV vaccines because of the risk of HBV infections. They also suggested that HBV vaccines might trigger NS relapses in some pediatric patients with NS [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Influenza virus vaccination in children with nephrotic syndrome: insignificant risk of relapse

et al. 2020

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Background Immunization with various vaccines is considered desirable for children with idiopathic nephrotic syndrome (NS) because of their high risk of severe infections. Vaccinations may precipitate relapses of NS, but there is no available data regarding inactivated influenza (flu) virus vaccines. Methods We retrospectively reviewed the medical records of children with NS who had received flu vaccines between 2002 and 2015. The day of flu vaccination was defined as day 0, and the period between the pre-vaccination and the post-vaccination days was defined as − X to + Y. The risk ratios and their 95% confidence intervals for NS relapse rate were estimated by generalized estimating equation (GEE) Poisson regression. Results A total of 104 pediatric patients received 208 flu vaccines. The mean age at onset of NS was at 4.85 ± 3.87 years old. There were 261 NS relapses between days − 180 and + 180. Compared with the relapse rate in the − 180 to 0 interval (1.19 times/person-year), those in 0 to + 30 (1.23), + 31 to + 60 (1.58), + 61 to + 90 (1.41), + 91 to + 120 (1.41), and + 121 to + 180 (1.32) days groups were slightly increased, but without significance. Multivariate analysis using GEE Poisson regression also showed no significant increase in relapse rate in each day group compared with days − 180 to 0. Risk ratios for NS relapse were significantly higher in children who were treated with steroids at the first vaccination. Conclusions Our results suggest that flu vaccines should not be avoided in children with NS based on the potential for NS relapses. Electronic supplementary material The online version of this article (10.1007/s10157-020-01930-8) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Influenza virus vaccination in children with nephrotic syndrome: insignificant risk of relapse

et al. 2020

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“…Yildiz and colleagues evaluated the effect of HBV vaccine among children with steroid sensitive nephrotic syndrome and they observed a low response to the HBV vaccination and some relapses due to this vaccination in these cases. Finally, they suggested that the HBV vaccination should only be used in patients on low dose or withdrawal of steroid therapy (33). …”

Section: The Present Situation Several Years After Starting the Sumentioning

confidence: 99%

Hepatitis B Vaccination: Needs a Revision

Rezaee‐Zavareh

Einollahi

2014

Hepat Mon

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“…The increased risk for relapse in children with nephrotic syndrome has also been reported for the HB vaccine [41,42]. The relapse rates of 41 children with SSNS were lower pre-vaccination (0.12 ± 0.19 per month) than post-vaccination (0.4 ± 0.12 per month; p = 0.002).…”

Section: Vaccine Safetymentioning

confidence: 55%

“…Inferior immunogenicity for three of the seven serotypes was observed in children who were also taking immunomodulators [39]. Reduced immune responses have also been reported in children with SSNS who received the HB vaccine [42]. In that study, HB seroconversion rates and the number of subjects with a protective titer of 10 mIU/mL or greater for antibody against HBsAg (anti-HBs) were lower among children who were taking steroids and also those who were not taking immunosuppressants; this suggested that SSNS was the major cause of their impaired immune responses.…”

Section: Vaccine Immunogenicitymentioning

confidence: 89%