Hepatitis B virus testing and linkage to care in a Canadian urban tertiary referral centre: a retrospective cohort study

Lau, Keith C.K.; Shaheen, Abdel Aziz; Aspinall, Alexander A.; Ba, Tazuko Ricento; Qureshi, Kamran; Congly, Stephen E.; Borman, Meredith A.; Jayakumar, Saumya; Eksteen, Bertus; Lee, Samuel S.; Stinton, Laura M.; Swain, Mark G.; Burak, Kelly W.; Coffin, Carla S.

doi:10.9778/cmajo.20170002

Cited by 7 publications

(8 citation statements)

References 24 publications

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“…However, HBV remains endemic in many areas of the Southeast Asia region and Africa, which have an estimated prevalence of 6.2% and 6.1%, respectively [ 1 , 3 ]. Within Canada, there are an estimated 260,000 chronically infected individuals (0.76% estimated prevalence), with the majority of those with CHB are new Canadians from endemic areas [ 3 , 4 ]. Within the Calgary Health Zone in Alberta, Canada, our prior research study reported a total of 1214 individuals (0.10% of population within Calgary zone) who tested positive for HBsAg within a single calendar year (2014) [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Within Canada, there are an estimated 260,000 chronically infected individuals (0.76% estimated prevalence), with the majority of those with CHB are new Canadians from endemic areas [ 3 , 4 ]. Within the Calgary Health Zone in Alberta, Canada, our prior research study reported a total of 1214 individuals (0.10% of population within Calgary zone) who tested positive for HBsAg within a single calendar year (2014) [ 4 ]. The majority of these cases are likely newly diagnosed CHB carriers, many of which lacked appropriate monitoring and management of their disease.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Hepatitis B Virus Genetic Variation, Integration, and Lymphotropism in Antiviral Treatment and Oncogenesis

2020

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Chronic Hepatitis B Virus (HBV) infection poses a significant global health burden. Although, effective treatment and vaccinations against HBV are available, challenges still exist, particularly in the development of curative therapies. The dynamic nature and unique features of HBV such as viral variants, integration of HBV DNA into host chromosomes, and extrahepatic reservoirs are considerations towards understanding the virus biology and developing improved anti-HBV treatments. In this review, we highlight the importance of these viral characteristics in the context of treatment and oncogenesis. Viral genotype and genetic variants can serve as important predictive factors for therapeutic response and outcomes in addition to oncogenic risk. HBV integration, particularly in coding genes, is implicated in the development of hepatocellular carcinoma. Furthermore, we will discuss emerging research that has identified various HBV nucleic acids and infection markers within extrahepatic sites (lymphoid cells). Intriguingly, the presence of hepatocellular carcinoma (HCC)-associated HBV variants and viral integration within the lymphoid cells may contribute towards the development of extrahepatic malignancies. Improved understanding of these HBV characteristics will enhance the development of a cure for chronic HBV infection.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of Hepatitis B Virus Genetic Variation, Integration, and Lymphotropism in Antiviral Treatment and Oncogenesis

2020

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“…Our finding of suboptimal laboratory assessment was in line with previous studies that found ALT testing in 97–98%, HBV DNA testing in 44–56% and HBeAg testing in less than 52% of HBsAg-positive patients within six months after diagnosis. 31 , 32 In our study, 77% had ALT testing, 42% had testing for HBV DNA and 80% had HBeAg testing. The accurate use of laboratory diagnostics can help differentiate those with need of antiviral therapy from those who need to be monitored for disease progression.…”

Section: Discussionmentioning

confidence: 52%

Cascade of care among hepatitis B patients in Maastricht, the Netherlands, 1996 to 2018

Oorschot

Koc

Lashof

et al. 2022

Journal of Virus Eradication

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“…In Alberta, administrative data on demographic characteristics and laboratory data were collected for 3 participating sites from the Alberta Health Services data repository, as previously described. 10 Crosssectional data analysis was done on the most recent patient record submitted. Fifteen sites submitted clinical data from 8 provincial health jurisdictions.…”

Section: Methodsmentioning

confidence: 99%

Epidemiologic and clinical features of chronic hepatitis B virus infection in 8 Canadian provinces: a descriptive study by the Canadian HBV Network

Coffin

Ramji

Cooper

et al. 2019

cmajo

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he hepatitis B virus (HBV) is a major human pathogen, with 257 million chronic carriers worldwideespecially in Asia and Sub-Saharan Africa-who remain at risk for cirrhosis, liver failure and hepatocellular carcinoma. 1,2 There are 8 major HBV genotypes, with a specific geographic and ethnic distribution, which have been linked to disease outcomes and response to antiviral therapy. 3 Hepatitis B is reportable to the Canadian Notifiable Disease Surveillance System, 4 yet reliable epidemiologic data are limited owing to the lack of standardized reporting practices and with reporting of only acutely infected people. A Public Health Agency of Canada report on hepatitis B and C in Canada in 2013 lacks data from 2 provinces (Newfoundland and Labrador, Prince Edward Island) and 2 territories (Northwest Territories, Nunavut). 5 Data from the Public Health Agency of Canada show lower estimates of chronic hepatitis B prevalence and incidence rate in British Columbia than those reported by the BC Centre for Disease Control owing to disparate reporting practices. 6 In a report from the Canadian Liver Foundation, it was estimated that 250 000

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Hepatitis B virus testing and linkage to care in a Canadian urban tertiary referral centre: a retrospective cohort study

Cited by 7 publications

References 24 publications

Impact of Hepatitis B Virus Genetic Variation, Integration, and Lymphotropism in Antiviral Treatment and Oncogenesis

Impact of Hepatitis B Virus Genetic Variation, Integration, and Lymphotropism in Antiviral Treatment and Oncogenesis

Cascade of care among hepatitis B patients in Maastricht, the Netherlands, 1996 to 2018

Epidemiologic and clinical features of chronic hepatitis B virus infection in 8 Canadian provinces: a descriptive study by the Canadian HBV Network

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