Hepatitis B Virus Reactivation After Three-Dimensional Conformal Radiotherapy in Patients With Hepatitis B Virus-Related Hepatocellular Carcinoma

Kim, Ji Hoon; Park, Joong-Won; Kim, Tae Hyun; Koh, Dong Wook; Lee, Woojin; Kim, Chang Min

doi:10.1016/j.ijrobp.2007.04.005

Cited by 91 publications

(89 citation statements)

References 29 publications

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“…Cheng et al (11) compared 65 HBV-related hepatocellular cancer (HCC) patients and 24 other HCC patients treated with three-dimensional conformal radiotherapy (3D-CRT) and found that the HCC patients who were HBV carriers presented with a statistically significantly greater susceptibility to radiation-induced liver disease following 3D-CRT. Kim et al (22) Table IV. Multivariate analysis of patients who developed hepatic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma

Zhu

Zhao

et al. 2012

Oncology Letters

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Abstract. In the present study, we reviewed 44 postgastrectomy adenocarcinoma patients who had hepatitis B and received treatment in the Abdominal Cancer Department of the West China Hospital between October 2006 and October 2010. Of these patients, 17 developed hepatic dysfunction. Radiotherapy is an independent risk factor to hepatic function on univariate and multivariate analysis. Grade III or IV hepatic dysfunction was developed by five patients, all of whom had received radiotherapy and had reactivated hepatic B virus (HBV). Radiotherapy is a significant risk factor to hepatic function in patients with postgastrectomy adenocarcinoma carrying HBV, thus we suggest excluding the liver from the radiation field. HBV reactivation plays a role in the development of grade III or IV hepatic dysfunction. Patients with reactivated HBV should immediately receive regular antiviral treatment.

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Section: Discussionmentioning

confidence: 99%

Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma

Zhu

Zhao

et al. 2012

Oncology Letters

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“…For the HCC patients in regions with endemic viral infection, the tolerance dose for RILD was shown to be lower and HBV infection predisposed patients to RILD, particularly for non-classic RILD presenting with jaundice or markedly elevated serum transaminases of more than five times the upper limit of the reference range (28,29). Radiation was shown to induce HBV reactivation, possibly through the bystander effect, and non-classic RILD further complicated the RILD for viral hepatitis-related HCC (30,31).…”

Section: Discussionmentioning

confidence: 99%

High-dose, Hypo-fractionated X-ray Radiotherapy for Hepatocellular Carcinoma: Tumor Responses and Toxicities

Huang

Tsang

Hong

2011

International Journal of Radiation Oncology*Biology*Physics

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Abstract. Hypofractionated radiotherapy (RT) has been employed to treat hepatocellular carcinoma (HCC). The present study aimed to report the treatment effects, the dose-response associations and the factors that are associated with radiation-induced liver disease (RILD) in a high-dose hypofractionated RT procedure. A total of 40 patients with non-metastatic HCC who underwent RT for local control of irradiated tumors were studied. The treatment technique was that of three-dimensional conformal or intensity-modulated radiation therapy, with a fraction size of 3 Gy and a total dose of 40-66 Gy in 14-23 fractions. The biologically-effective dose (BED) was 52.0-85.8 Gy 10 (median, 74.1 Gy 10 ). Tumor regression was observed in 28 patients (70.0%) with a complete response, partial response, stable disease and progressive disease status in 11 (27.5%), 17 (42.5%), five (12.5%) and seven patients (17.5%), respectively. The one-, two-and five-year overall survival (OS) and in-field control (IFC) rates were 60, 40 and 21% and 73, 62 and 56%, respectively. A positive correlation also emerged between the radiation dose and the IFC (P=0.035). Eight of the 40 patients (20%) developed non-classic RILD. A higher Cancer of the Liver Italian Program score was associated with a higher probability of non-classic RILD (P=0.02). The tumor response and IFC rate of HCC following irradiation were significantly dose-dependent. High-dose hypofractionated X-ray RT is a feasible and effective treatment for HCC in patients with good liver function and for those who meet the criteria for a curative attempt.

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“…The rate of hbv reactivation was significantly greater in the group that was not treated with lamivudine [7 of 32 (21.8%) vs. 0 of 16 (0%), p < 0.05]. The rate of spontaneous hbv reactivation in the control group with hcc who received neither radiotherapy nor suppressive therapy for chronic hbv was 2.3% 59 . These studies suggest that radiation therapy for hcc increases the risk of hbv reactivation and that hbv suppressive therapy such as lamivudine reduces that risk.…”

Section: Summary Of Evidencementioning

confidence: 92%

“…In two retrospective case series (n = 69 and n = 32), the rate of hbv reactivation associated with radiotherapy for hcc was approximately 20% 59,60 . Patients receiving conformal radiation for hcc who also received lamivudine before and during conformal radiation were compared with those who did not.…”

Section: Summary Of Evidencementioning

confidence: 99%

Eastern Canadian Gastrointestinal Cancer Consensus Conference 2016

Bossé

Ahmad

et al. 2016

Current Oncology

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The annual Eastern Canadian Gastrointestinal Cancer Consensus Conference 2016 was held in Montreal, Quebec, 5-7 February. Experts in radiation oncology, medical oncology, surgical oncology, and infectious diseases involved in the management of patients with gastrointestinal malignancies participated in presentations and discussion sessions for the purpose of developing the recommendations presented here. This consensus statement addresses multiple topics:■ Follow-up and survivorship of patients with resected colorectal cancer ■ Indications for liver metastasectomy ■ Treatment of oligometastases by stereotactic body radiation therapy ■ Treatment of borderline resectable and unresectable pancreatic cancer ■ Transarterial chemoembolization in hepatocellular carcinoma ■ Infectious complications of antineoplastic agents

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Hepatitis B Virus Reactivation After Three-Dimensional Conformal Radiotherapy in Patients With Hepatitis B Virus-Related Hepatocellular Carcinoma

Cited by 91 publications

References 29 publications

Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma

Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma

High-dose, Hypo-fractionated X-ray Radiotherapy for Hepatocellular Carcinoma: Tumor Responses and Toxicities

Eastern Canadian Gastrointestinal Cancer Consensus Conference 2016

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