Hepatitis B virus infection status and infertility causes in couples seeking fertility treatment—Indicator of impaired immune response?

Lao, Terence T.; Mak, Jennifer Sze Man; Li, Tin‐Chiu

doi:10.1111/aji.12636

Cited by 18 publications

(22 citation statements)

References 35 publications

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“…Earlier studies in SARS-CoV, which also targeted the same receptor, have revealed that numerous patients had evidence of testicular inflammation (orchitis) [ 230 ]. Indeed, a range of other viral infections such as HIV, mumps, hepatitis B, and human papillomavirus has been shown to cause male sterility, altered expression of hormones, and may even be linked to increased risk of testicular cancer [ 231 , 232 , 233 , 234 , 235 ]. One study demonstrated that the ratio of testosterone and follicle-stimulating hormone to serum luteinizing hormone was significantly decreased in young adult male COVID-19 patients ( n = 81) compared to controls ( n = 100) [ 229 ].…”

Section: How Might Ergothioneine Be Beneficial In Alleviating Covimentioning

confidence: 99%

Could Ergothioneine Aid in the Treatment of Coronavirus Patients?

Cheah

Halliwell

2020

Antioxidants

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Infection with SARS-CoV-2 causes the coronavirus infectious disease 2019 (COVID-19), a pandemic that has, at present, infected more than 11 million people globally. Some COVID-19 patients develop a severe and critical illness, spurred on by excessive inflammation that can lead to respiratory or multiorgan failure. Numerous studies have established the unique array of cytoprotective properties of the dietary amino acid ergothioneine. Based on studies in a range of in vitro and in vivo models, ergothioneine has exhibited the ability to modulate inflammation, scavenge free radicals, protect against acute respiratory distress syndrome, prevent endothelial dysfunction, protect against ischemia and reperfusion injury, protect against neuronal damage, counteract iron dysregulation, hinder lung and liver fibrosis, and mitigate damage to the lungs, kidneys, liver, gastrointestinal tract, and testis, amongst many others. When compiled, this evidence suggests that ergothioneine has a potential application in the treatment of the underlying pathology of COVID-19. We propose that ergothioneine could be used as a therapeutic to reduce the severity and mortality of COVID-19, especially in the elderly and those with underlying health conditions. This review presents evidence to support that proposal.

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Section: How Might Ergothioneine Be Beneficial In Alleviating Covimentioning

confidence: 99%

Could Ergothioneine Aid in the Treatment of Coronavirus Patients?

Cheah

Halliwell

2020

Antioxidants

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“…Более высокая, по сравнению с популяционной, частота встречаемости вирусных гепатитов С и В, обнаруженная нами в подгруппе бесплодных муж-чин, соответствует результатам аналогичных работ, выполненных в других странах [22], авторы которых отметили, что у больных гепатитом мужчин наблю-даются менее высокие показатели объема эякулята, концентрации и подвижности сперматозоидов.…”

Section: Discussionunclassified

Prevalence of sexually transmitted diseases among men from infertile couples

et al. 2018

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Introduction. Sexually transmitted diseases (STDs) can potentially disrupt male fertility; however, the prevalence data for STDs among men from infertile couples is controversial. Aim. The aim of the study was to estimate the prevalence of STDs among men from infertile couples seeking medical assistance in an assisted reproductive technology clinic. Materials and methods. We retrospectively studied the medical records of 307 men (mean age: 35 ± 15 years) consecutively attending an outpatient reproductive clinic for infertility treatment. Duration of the infertile period varied from 4 to 228 months (mean: 38 ± 12 months). We collected urethral swab specimen to investigate the presence of Neisseria gonorrhoeae, Trichomonas vaginalis, Chlamydia trachomatis, Mycoplasma, and Ureaplasma species in 235 (76.5%), 232 (75.6%), 270 (87.9%), 301 (98.1%), and 300 (97.7%) men, respectively. Blood tests for syphilis, hepatitis B and C, human immunodeficiency virus (HIV), human herpesvirus (HHV), and cytomegalovirus (CMV) were conducted in 229 (74.6%), 224 (73%), 227 (73.9%), 230 (74.9%), 233(75.9%), and 232 (75.6%) men, respectively, and statistical analysis of the data was performed. Results. Remarkably, all tests were negative in 94 (30.6%) men, and no patient had T. vaginalis or C. trachomatis infection. However, N. gonorrhoeae, Mycoplasma, and Ureaplasma were detected in 1 (0.4%), 6 (2.6%), and 14 (4.7%) men, respectively. Syphilis, hepatitis B and C, HIV, HSV, and CMV tests were positive in 1 (0.4%), 2 (0.9%), 6 (2.6%), 1(0.4%), 177 (76%), and 133 (57%) men, respectively. Conclusions. The prevalence of STDs is high among men from infertile couples. Further studies are warranted to investigate the relationship between STDs and male infertility. (For citation: Korneyev IA, Zasseev RD, Shevchuk IG, Pelipejchenko AA. Prevalence of sexually transmitted diseases among men from infertile couples. Urologicheskie vedomosti. 2018;8(2):30-35. doi: 10.17816/uroved8230-35).

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“…Impaired immune response is supposedly one of the noteworthy linkage between the two. 86 Hepatitis can also affect the success of in vitro fertilization (IVF). 87,88 Glucagon-like peptide (GLP) regulates secretion of insulin and maintains the balance between the requirement of sugar in the body by causing excess to be converted into glycogen.…”

Section: Liver Diseasementioning

confidence: 99%

Human immunodeficiency: Extragonadal comorbidities of infertility in women

Lorzadeh

Kazemirad

2020

Immunity Inflam & Disease

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Introduction: Infertility is mediated by several changes system-wide. These changes are likely to cause other systems-related pathologies, such as changes in systemic immune response, particularly inflammatory response can lead to cardiovascular diseases and breast cancer. Methods: These morbidities can exist immediately or years after the diagnosis of infertility. Therefore, understanding the mechanism is important to move toward therapeutic interventions. Results: Several extragonadal pathologies are reported due to infertility, as well as, how these might also contribute to reproductive disabilities. Detailed evidence are still not present that can give stronger result. Conclusion: This review highlights some of the most frequent comorbidities that are seen in infertile women, hence requiring a need for complete clinical screening and care, as well as diagnosis and treatment in early stages. K E Y W O R D S extragonadal comorbidities, infertile women, infertility 1 | INTRODUCTION Up to 18% of general population is prone to infertility. 1 However, fewer studies target coexisting pathologies with infertility. Infertility is not a remote pathology and it can proffer effects on various systems in the body. Women infertility can have several causes, such as polycystic ovary syndrome (PCOS), endometriosis, tubal blockage, and hydrosalpinges. 2-4 Despite, availability of diversity of treatment options, prevalence extragonadal pathologies might influence the treatment outcomes for infertility. 5,6 Certain dietary intake can also elevate the risk to attain infertility. 7 A study reports genital infections like those in vagina, uterus, and ovaries that greatly contributes to infertility rather than cardiovascular factors. 8 PCOS is characterized by various phenotypes (Figure 1) and thereby existence of comorbidities varies according to each category. In general, these women present elevated body mass index (BMI), follicle count

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Hepatitis B virus infection status and infertility causes in couples seeking fertility treatment—Indicator of impaired immune response?

Cited by 18 publications

References 35 publications

Could Ergothioneine Aid in the Treatment of Coronavirus Patients?

Could Ergothioneine Aid in the Treatment of Coronavirus Patients?

Prevalence of sexually transmitted diseases among men from infertile couples

Human immunodeficiency: Extragonadal comorbidities of infertility in women

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