Hepatitis B Virus Infection Profile in Different Hemodialysis Units in Recife, Pernambuco, Brazil

Albuquerque, Ana Cecília Cavalcanti de; Coêlho, Maria Rosângela Cunha Duarte; Lemos, Marcílio Figueiredo; Cruz, Ana; Braz, Suellen C. M.; Moreira, Regina Célia

doi:10.17525/vrrjournal.v14i1.25

Cited by 2 publications

(4 citation statements)

References 23 publications

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“…The greater frequency of infection due to genotype A found in this study has also been identified in Salvador, 11 Pernambuco 12 and the Amazon region. 4 Genotype A is always detected in Brazilian studies and sometimes is predominantly associated with genotype D 6 , 13 and sometimes with type F. 11 , 16 However, in Alagoas, genotype A was accompanied by genotype C, emphasizing that the infection due to genotype A was also found in a patient of Asian ethnicity.…”

Section: Resultssupporting

confidence: 80%

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Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions

Eloy¹,

Moreira²,

Lemos³

et al. 2013

The Brazilian Journal of Infectious Diseases

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The aims of this study were to investigate the genotypes of hepatitis B virus and to identify the precore G1896A and basal core promoter A1762T/G1764A mutations in HBsAg and anti-HBc-positive patients. Eighty-three asymptomatic individuals, three with acute hepatitis B and 33 with chronic hepatitis B referred to viral hepatitis centers in the State of Alagoas, Brazil were analyzed according to their viral load, HBeAg/anti-HBe profile and alanine aminotransferase serum level. The genotypes identified were: A (92.5%), C (5%), D (1.25%) and F (1.25%). The precore mutation was detected in 3.8% of sequences and basal core promoter mutation in 52.4%. These were identified in 45.45% of the asymptomatic individuals and 54.55% of the patients with chronic hepatitis, irrespective of viral load and alanine aminotransferase serum level. In genotype C, only the basal core promoter mutation was identified and no mutations were identified in genotypes D and F.

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Section: Resultssupporting

confidence: 80%

“…It is predominant in the southern and southeastern regions, which are areas where Italian immigration took place, 6 , 11 , 13 and its frequency is lower in the northeastern region. 11 , 12 …”

Section: Resultsmentioning

confidence: 99%

Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions

Eloy¹,

Moreira²,

Lemos³

et al. 2013

The Brazilian Journal of Infectious Diseases

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“…Ferreira et al (2006) analysed 1,095 HD patients from Goiás and observed that 272 (24.8%) tested positive against anti-hepatitis B core antibody (anti-HBc) and anti-hepatitis B surface antibody (anti-HBs); hepatitis B surface antigen (HBsAg) was also detected in 26 of them (2.4%). Albuquerque et al (2009) observed that 29.4% of patients under HD from five clinics in Recife (Pernambuco, Brazil) tested positive against anti-HBc antibody and HBsAg was detected in 3.3% of patients. These authors were in agreement that 54% of patients were either positive for HBsAg, HBV DNA or both.…”

mentioning

confidence: 99%

“…Our findings regarding HBV markers are in accordance with previous reports, despite the lack of a Brazilian National Survey of HBV infection among HD subjects. Souza et al (2003) observed that 39% of HD patients from Tocantins, Brazil were positive for anti-HBc, while Albuquerque et al (2009) reported that 29.4% were positive for anti-HBc and 3.3% for HBsAg in the Northeastern Region of Brasil. In the South, the prevalence was reported to be 10% for HBsAg and 32.2% for anti-HBc (Carrilho et al 2004).…”

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confidence: 99%

HBV markers in haemodialysis Brazilian patients: a prospective 12-month follow-up

Moreira

Deguti²,

Lemos

et al. 2010

Mem. Inst. Oswaldo Cruz

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The aim of this study was to determine the prevalence and the incidence of hepatitis B virus (HBV) among haemodialysis (HD) subjects and to evaluate whether testing for serological markers at the time of admission is suitable for HBV screening in this population. One hundred twenty-three patients belonging to two HD centres from SãoPaulo, Brazil, were tested prospectively. HBV DNA was detected by polymerase chain reaction (PCR) and HBsAg was detected in 3.3% of patients. These authors were in agreement that 54% of patients were either positive for HBsAg, HBV DNA or both. The aim of this study was to determine the prevalence and the incidence of HBV among HD patients and to evaluate whether testing for serological markers at the time of admission is suitable for HBV screening in this population.All patients (n = 123) undergoing treatment in two HD centres from March 1997-April 1998 were included in this study. The study protocol was submitted and approved by the Ethical Committee of Adolfo Lutz Institute and an informed consent was obtained from each patient. These facilities were considered to be representative of local (São Paulo, Brazil) standard HD services. Both units were comparable in terms of the budget per subject, presence of an isolated area for HBV and HCV patients, recommendation of HBV vaccination for patients and staff and isolation of HBsAg-positive patients to the last shift of the HBV room. These HD centres had standard conditions as determined by Brazilian competent organs and by the CDC guidelines, including isolation of HBsAg-positive patients in a separate room and assignment of staff members to HBsAg-positive patients, but not to HBV-susceptible patients during the same shift, as well as assignment of a supply tray to each patient (CDC 2001, MS 2004.HD patients had previously received four doses of 40 µg of Engerix™ B, administered intramuscularly at zero, one, two and six months. Once a year, anti-HBs is quantified and one dose of vaccine is administered, if necessary. Patients had 10 mL of blood drawn from arterial-venous fistula just before the HD procedure, at the time of admission and on a monthly basis. Therefore, a total of 1,476 serum samples were obtained and separated into the following three aliquots: serological tests, PCR and reconfirmation, if necessary. Samples were stored at -20°C in a separate freezer.The first and the last samples from each patient were tested for HBV DNA using DNA extraction and nested PCR (core fragment) techniques, as previously described (Kaneko et al. 1989). All 1,476 samples were tested for HBsAg, total anti-HBc and anti-HBs antibodies using commercially available ELISA kits (Hepanostika™ Uni-

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Hepatitis B Virus Infection Profile in Different Hemodialysis Units in Recife, Pernambuco, Brazil

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Cited by 2 publications

References 23 publications

Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions

Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions

HBV markers in haemodialysis Brazilian patients: a prospective 12-month follow-up

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