Hepatitis B virus infection on male partner has negative impact on in-vitro fertilization

Lubis, Hilma Putri; Halim, Binarwan; Adenin, Ichwanul; Rusda, Muhammad; Prasetiawan, Eka

doi:10.1088/1755-1315/125/1/012045

Cited by 4 publications

(8 citation statements)

References 12 publications

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“…Among several studies [19][20][21][22][23] that have addressed the reproductive performance of couples infected with HBV, results are discordant. Some studies [19,20] showed significantly lower implantation in couples conflicting for HBV infection, while others reported a higher implantation rate in couples of HBV infection than the control individuals [23].…”

Section: Discussionmentioning

confidence: 99%

Analyzing the detrimental effects of female chronic hepatitis B virus DNA on ovarian reserve function and results of in vitro fertilization

Liu¹,

Liang²,

Yang³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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Background: To evaluate both the impact of hepatitis B virus (HBV)-DNA copies in women with HBV infection on the ovarian reserve function and outcomes of in vitro fertilization (IVF). Methods: We conducted a retrospective study on a total of 9927 couples undergoing their first IVF cycle. After filtering, 1570 couples (546 HBV-seropositive women and 1024 HBV-seronegative women whose partners were HBV-seronegative) failed to meet inclusion criteria. According to the HBV-DNA titers in serum, the HBV-seropositive group was divided into three groups: DNA-high copy group (n = 139), DNA-low copy group (n = 241), and DNA-negative group (n = 166). All patients underwent controlled ovarian hyperstimulation using the long downregulation protocol followed by IVF. Results: Compared with the HBV-negative group, HBV-positive women with high DNA copy exhibited lower antral follicle count (AFC) (11.9 ± 4.3 vs 13.3 ± 3.2), lower number of oocyte retrieved (9.2 ± 5.7 vs 13.1 ± 6.1), larger proportion of AFC <8 (7.9% vs 3.1%) and anti-mullerian hormone (AMH) <2 µg/L (8.6% vs 4.3%). Both high-DNA copy and low-DNA copy groups exhibited a lower fertilization rate (70.9% and 72.5% vs 75.1%), lower high-grade embryo rate (51.5% and 53.8% vs 56.9%), lower implantation rate (31.3% and 32.7% vs 38.5%), lower clinical pregnancy rate (40.3% and 42.3% vs 49.6% per cycle with OR; 45.5% and 48.8% vs 56.8% per cycle with ET) than the HBV-negative group. Moreover, a higher early abortion rate (19.6% and 15.7% vs 7.1%) was observed in the above two groups. Conclusion: HBV-DNA may have a negative effect on women's ovarian reserve function which in turn results in poor fertilization rate, clinical pregnancy rate and high early abortion rate in IVF treatment.

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Section: Discussionmentioning

confidence: 99%

Analyzing the detrimental effects of female chronic hepatitis B virus DNA on ovarian reserve function and results of in vitro fertilization

Liu¹,

Liang²,

Yang³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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“…Despite following all these recommendations, it is not clear whether such infection plays a role on the outcome of the IVF or ICSI (intracytoplasmic sperm injection) cycle. Some studies have indicated that such condition does not significantly influence the outcome of the IVF/ICSI cycle [12][13][14], while on the other hand, some studies have shown that these patients could have significantly impaired outcomes [15,16]. The reason for such differences in outcomes may be in a low number of included patients in some studies, which were mostly single institutional.…”

Section: Introductionmentioning

confidence: 99%

“…The reason for such differences in outcomes may be in a low number of included patients in some studies, which were mostly single institutional. For example, the study by Cito et al [12] had 134 infertile couples included, where 66 couples had HBsAg-seropositive men and 68 were controls; the study by Bu et al [13] had 277 couples, where 20 men were HBC seropositive; the study by Lubis et al [15] had 101 included patients, with 17 males in the HBV group and 84 in the control group. On the other hand, studies by Wang et al [14] and Lin et al [16] had a higher number of included patients.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B Infection Negatively Affects the Outcome of Fresh IVF/ICSI Cycles

Petric¹,

Fevzer²,

Jančar³

et al. 2022

JOMH

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Background:The study sought to determine whether hepatitis B infection in females and males plays a role in the outcome of the IVF/ICSI cycle. Methods: We performed a retrospective analysis of data collected from IVF/ICSI cycles carried out from January 2011 to December 2019 at the University Medical Centre Ljubljana. The data was analyzed using Pearson's chi-square test, Fisher's exact test, and Kruskal-Wallis test in order to determine the differences between the groups. Results: This study included 117 cycles with a past female hepatitis B infection (HF group), 91 cycles with couples with a past male hepatitis B infection (HM group), and 10,216 cycles with no past male or female hepatitis B infection (control group). There was no difference in sperm concentration, but total sperm motility was significantly higher in the HF and control groups compared to the HM group (p = 0.008 and p < 0.001). Also, sperm morphology was significantly higher in the control group, compared to both, the HM group (p < 0.001) and the HF group (p = 0.004). Furthermore, the rate of fertilized oocytes per number of retrieved oocytes was significantly higher in the HF (p < 0.001) and control groups (p = 0.003) compared to the HM group, but on the contrary, the rate of immature oocytes was lower in the HM (p = 0.009) and control groups (p = 0.001) compared to the HF group. The number of obtained embryos, blastocyst, and embryo utilization rates were similar between the groups, although the rate of cryopreserved embryos was higher in the HF (p = 0.007) and the HM groups (p = 0.027) compared to the control group. No significant difference was observed in the pregnancy and live birth rate per embryo transfer, while a trend towards a lower birth rate per aspiration was observed in the HM and in HF groups, which can be explained with a significantly higher miscarriage rate observed in the HM (p < 0.001) and HF groups (p = 0.042) compared to the control group. Gestational age was similar for all groups, although we observed a strong trend towards a higher birth weight of singletons in the HF group (p = 0.043) compared to the control group. Conclusions: The results indicate that hepatitis B infection could have a detrimental influence on sperm motility and morphology and cycle outcome, especially in terms of a higher miscarriage rate.

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“…One of the effects of hepatitis B diseases is hepatocellular carcinoma (HCC) (2). Transmission of HBV is parenteral, in contact with blood or other body fluids (3,4). In addition, intra-familial transmission is a potential source of HBVinfected patients (5).…”

Section: Introductionmentioning

confidence: 99%

Assessment for Retreatment with Trans arterial Chemoembolization Score Effectiveness for Selecting Hepatocellular Carcinoma Patients Undergoing Repeated Therapy (ART Score Predicting Repeated TACE Impact on Overall Survival)

2020

SRP

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Repeated transarterial chemoembolization (TACE) treatment is often needed to increase tumor response and survival of unresectable hepatocellular carcinoma (HCC) patients. However, not all patients experience similar benefit from retreatment. This study aimed to determine the effectivity of the Assessment for Retreatment with TACE (ART) score and clinical determinant in predicting repeated TACE impact on overall survival (OS). This study was a retrospective analysis towards HCC patients undergoing at least 2 TACE sessions was performed. The ART score was calculated one day before each repeated TACE session, and patients were divided into 0-1.5 and ≥ 2.5 groups. Out of thirty-two HCC patients, 59.4% (n=19) patients revealed ART score 0-1.5 points, while 40.6% (n=13) patients had score ≥ 2.5 points prior to TACE-2 session. Median OS of the whole subject was 7.6 months (95% CI: 5.9-9.3) with overall 1-year survival rate of 28.2%. The ART score was found to be a significant predictor of survival (median OS and ART score of 0-1.5 vs. ≥ 2.5 points; 11 vs 4.9 months; respectively, P = 0.020), although in sub-analysis according to time intervals (≤90 vs. >90 days) showed no statistically difference that might be due to low sample size. Moreover, AFP levels >200 ng/mL was the only one clinical determinant that associated with poor survival. The ART score has potential to be a significant predictor of OS as well as AFP levels for HCC patients who undergo retreatment with TACE.

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Hepatitis B virus infection on male partner has negative impact on in-vitro fertilization

Cited by 4 publications

References 12 publications

Analyzing the detrimental effects of female chronic hepatitis B virus DNA on ovarian reserve function and results of in vitro fertilization

Analyzing the detrimental effects of female chronic hepatitis B virus DNA on ovarian reserve function and results of in vitro fertilization

Hepatitis B Infection Negatively Affects the Outcome of Fresh IVF/ICSI Cycles

Assessment for Retreatment with Trans arterial Chemoembolization Score Effectiveness for Selecting Hepatocellular Carcinoma Patients Undergoing Repeated Therapy (ART Score Predicting Repeated TACE Impact on Overall Survival)

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