Hepatitis B virus infection associated with polyarteritis nodosa and microscopic polyangiitis

Meng, Zhou; Cui, Wei; Arend, Lois J.; Mikdashi, Jamal

doi:10.1136/bcr-2020-240015

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…In contrast, occult HBV infection occurs in older individuals, and immunosuppressive treatments may induce de novo HBV hepatitis [ 14 ]. HBV infects various immunological cells, such as lymphocytes, and induces immunogenicity [ 15 ]. Occult HBV infection can trigger PAN.…”

Section: Discussionmentioning

confidence: 99%

“…Investigation for occult HBV infection is mandatory in patients with suspected vasculitis, including those with PAN. However, the treatment of occult HBV infection is controversial because of the side effects of medications for HBV infections [ 15 ]. Our patient tested negative for HBV DNA; therefore, he was not treated with HBV antiviral drugs.…”

Section: Discussionmentioning

confidence: 99%

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Comprehensive Management of Vasculitis and Suspected Polyarteritis Nodosa in an Older Patient

Ohta¹,

Sano²

2023

Cureus

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Polyarteritis nodosa (PAN) is a rare autoimmune disease that affects medium-sized arteries and causes inflammation and damage to the blood vessel walls. Testicular pain is an uncommon symptom of PAN but can occur in rare cases. This specific symptom may be useful in diagnosing older patients with limited tissue access because of their vulnerability and high risk for biopsy complications. We report the case of a 78-yearold male patient with progressive fatigue and walking difficulty. After ruling out various forms of vasculitis and malignancy, we diagnosed the patient with PAN and intensively treated him with rituximab, which successfully cured his symptoms. This case report highlights the importance of intensively ruling out possible diagnoses mimicking vasculitis and treating vasculitis with a tentative diagnosis of PAN in older patients in rural hospitals. The progressive clinical course of vasculitis may devastate older patients' activities of daily living (ADLs). PAN may particularly affect older patients with possible hepatitis B infections. Thus, shared decision-making and prompt intensive treatment should be considered.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comprehensive Management of Vasculitis and Suspected Polyarteritis Nodosa in an Older Patient

Ohta¹,

Sano²

2023

Cureus

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Viral Infections

Harwood,

Sterling

2024

Rook's Textbook of Dermatology

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Viruses can cause disease in the skin or mucosa by direct infection or, via a systemic infection, produce secondary skin abnormalities. The chapter reviews the viruses associated with skin lesions, outlining the pathophysiology, the clinical features, diagnostic methods and the approaches to treatment. Primary skin infection following direct contact occurs with poxviruses, some herpesviruses and papillomaviruses leading to visible features which may be readily diagnostic. Less specific skin changes are seen with systemic infections, when infection is often via mucosae or inoculation, for example with parvovirus, measles or coronavirus and for these infections, diagnosis will usually involve body fluid analysis.

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An Atypical Case of Hepatitis B-Associated Vasculitis

Ren,

El Hasbani,

Jenkins

et al. 2023

EMJ

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One of the many extra-hepatic manifestations of hepatitis B virus (HBV) infections is vasculitis. While the classic HBV-associated vasculitis is polyarteritis nodosa, other vasculitides have been reported. The authors present an atypical case of acute HBV-associated vasculitis in a 57-year-old male with tobacco use disorder, characterised by extremity ischaemia, gangrene, splenic infarction, and positive proteinase-3 antibodies without sinopulmonary, gastrointestinal, or renal disease. The aggressiveness of the patient’s disease necessitated pulse-dose corticosteroids, cyclophosphamide, and two courses of plasmapheresis, and ultimately required multiple amputations of fingers and toes.

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Hepatitis B virus infection associated with polyarteritis nodosa and microscopic polyangiitis

Cited by 3 publications

References 12 publications

Comprehensive Management of Vasculitis and Suspected Polyarteritis Nodosa in an Older Patient

Comprehensive Management of Vasculitis and Suspected Polyarteritis Nodosa in an Older Patient

Viral Infections

An Atypical Case of Hepatitis B-Associated Vasculitis

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