Hepatitis B virus infection and the risk of male infertility: a population-based analysis

Su, Fu Hsiung; Chang, Shih Ni; Sung, Fung Chang; Su, Chien Tien; Shieh, Ying Hua; Lin, Cheng Chieh; Yeh, Chih Ching

doi:10.1016/j.fertnstert.2014.09.017

Cited by 37 publications

(34 citation statements)

References 27 publications

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“…The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95 % CI 1.20-1.92) after adjusting for covariates in a multivariate Cox proportional hazards model. Their data showed an increased incidence and risk of infertility among men with HBV infection compared with men without HBV [9].…”

Section: Discussionmentioning

confidence: 98%

“…Virus-induced chronic active hepatitis enhances oxidative stress in the reproductive system, aggravates sperm damage, and affects sperm quality parameters [8]. In Su et al's paper [9], the incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95 % CI 1.20-1.92) after adjusting for covariates in a multivariate Cox proportional hazards model.…”

Section: Discussionmentioning

confidence: 99%

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Viral Hepatitis and Assisted Reproduction

Allahbadia

2015

J Obstet Gynecol India

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Infertility treatment in couples where one or both parents are infected with hepatitis raises many concerns about transmission of the infection to the baby, laboratory technicians, and medical staff, and contamination of other gametes/embryos that are from virus-free parents in the same laboratory. Exposure to the other partner is only a risk when the couple's hepatitis status is discordant. The management of infertility, in association with HBV or HCV, has sparked debates about the potential risk of spread of infection to virus-free individuals, embryos, and/or semen. This risk can only be minimized or eliminated by the use of SOPs for safety in fertility clinics and by the use of proper initial detection and segregation of potentially hazardous materials. HBV may interfere with the development of embryos and even result in abortion and other adverse outcomes. Although sexual transmission of HCV is very low, in subfertile or infertile couples sperm washing should be used to treat HCV-positive semen before ART.Testing for HBsAg and HCV should be offered to high-risk infertile couples seeking fertility therapy to reduce the potential risk of transmission to an uninfected partner, baby, staff members, and disease-free gametes and embryos in the same laboratory. Testing for HIV, HBsAg,

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Viral Hepatitis and Assisted Reproduction

Allahbadia

2015

J Obstet Gynecol India

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“…Su et al . did a survey and found an increased incidence and risk of infertility among men with hepatitis B virus (HBV) infection compared with men without HBV infection . Gimenes et al .…”

Section: Discussionmentioning

confidence: 99%

“…Su et al did a survey and found an increased incidence and risk of infertility among men with hepatitis B virus (HBV) infection compared with men without HBV infection. 17 Gimenes et al reviewed literatures and indicated that hepatitis B and hepatitis C viruses, human papillomavirus, HIV-1 and human cytomegalovirus were detected in the semen from those with symptomatic and asymptomatic testicular, accessory gland and urethral infections. These pathogens are associated with poor sperm quality and decreased sperm concentration and motility.…”

Section: Discussionmentioning

confidence: 99%

Activation of Toll like receptor 3 induces spermatogonial stem cell apoptosis

Song

Luo

et al. 2015

Cell Biochemistry & Function

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Germ cell apoptosis may be associated with the male infertility. The pathogenesis is to be further understood. Viral infection is one of the causative factors of apoptosis of the body cells. This study aims to investigate the role of activation of Toll like receptor (TLR)3 in the induction of germ cell apoptosis. In this study, spermatogonial stem cells (SSC) were isolated from C57BL/6 mouse testes. The expression of TLR3 on SSC was by RT-qPCR and Western blotting. polyinosinic-polycytidylic acid (Poly I:C) was employed to activate TLR3 on SSCs. The results showed that re-activation by PolyI:C induced SSC apoptosis. Exposure to PolyI:C induced interferon regulatory factor 3 (IRF3) phosphorylation in SSCs. TLR3 and IRF3 formed a complex in the SSCs. The complex of TLR3/IRF3 bound to the promoter of Fas ligand and promoted Fas ligand expression in SSC, and thus induced SSC apoptosis. In conclusion, the results of the present study indicate that activation of TLR3 by PolyI:C induces the SSC apoptosis, which implies that viral infection may interfere with the male germ cell development.

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“…Patients providing material to be cryopreserved must be screened for transmissible infections before cryostorage, the option being separate quarantined storage in individual vessels . Hepatitis B infection has been shown to increase the risk of male infertility and be associated with reduced oocyte fertilisation . Hepatitis B, hepatitis C and HIV have all been associated with reduced semen parameters though it is not entirely clear whether this is a consequence of the disease, the treatment or both.…”

Section: Introductionmentioning

confidence: 99%

Incidence of transmissible diseases in a network of assisted reproduction clinics throughout Queensland

Harrison¹,

Darling²,

Vargas³

et al. 2015

Aust NZ J Obst Gynaeco

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In assisted reproduction, knowledge of the presence of transmissible disease assists diagnosis and permits appropriate risk minimisation. The overall incidence was lowest in the Brisbane full-cost clinic and highest in the Springwood low-cost clinic. Male partners predominated over females, particularly in the low-cost clinic. Hepatitis C was the most commonly detected infection with the highest incidence in the low-cost clinic. HIV was the least commonly detected infection amongst those tested.

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Hepatitis B virus infection and the risk of male infertility: a population-based analysis

Cited by 37 publications

References 27 publications

Viral Hepatitis and Assisted Reproduction

Viral Hepatitis and Assisted Reproduction

Activation of Toll like receptor 3 induces spermatogonial stem cell apoptosis

Incidence of transmissible diseases in a network of assisted reproduction clinics throughout Queensland

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