Hepatitis B Virus‐Hepatitis D Virus mother‐to‐child co‐transmission: A retrospective study in a developed country

Sellier, Pierre; Maylin, Sarah; Brichler, Ségolène; Berçot, Béatrice; Lopes, Amanda; Pogliaghi, Manuela; Munier, Anne‐Lise; Delcey, Véronique; Simoneau, Guy G.; Evans, John; Gordien, Emmanuel; Simon, François; Bergmann, Jean‐François

doi:10.1111/liv.13556

Cited by 41 publications

(21 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chronic HBV infection makes young patients susceptible to the horizontal transmission of HDV in high prevalent areas. HBV/HDV mother-to-child co-transmission is rare [ 8 , 18 ]. These findings from Pakistan are broadly similar to those from a study conducted in a remote rural community in central Africa, where a high prevalence of HBsAg carriage and HDV infection in children and adolescents was observed [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…HDV infection is an important cause of progressive liver disease in children who are chronic hepatitis B surface antigen (HBsAg) carriers [ 7 ]. The acquisition of HDV infection occurs primarily through horizontal transmission [ 8 ]. Children infected with HDV typically have minimal symptoms and high levels of HBV replication in the liver with the presence of hepatitis B core antigen (HBcAg) in the liver and hepatitis B e-antigen (HBeAg) and HBV DNA in the serum [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Severity of Hepatitis D in Young Adults of Age 18-25 Years

Abbas

Qadeer

Mandviwalla

et al. 2020

Cureus

View full text Add to dashboard Cite

Background Current literature on the prevalence and characteristics of hepatitis D virus (HDV) infection in young adults is limited. This study aims to determine the disease characteristics and severity in young adults. Methods The case records of HDV RNA positive patients of age 18-25 years were analyzed. Results Out of 119 patients, 105 (88%) patients were male. HBV-DNA was detectable in 83 (70%). Hepatitis B eantigen (HBeAg) was non-reactive in 99 (83%). Cirrhosis was identified in 45 (37.8%) individuals; nine (7.5%) were classified as Child class B or Child class C. Twenty-four (20.2%) had a Model For End-Stage Liver Disease (MELD) score of ≥10, out of these 16 had a score of 15 or more. The risk of decompensation was calculated according to the Baseline-event-anticipation (BEA) score; eight (6.7%) patients were at BEA-A (mild risk), 105 (88.2%) were at BEA-B (moderate risk), and six (5.0%) were at BEA-C (severe risk). Notable findings in patients with cirrhosis included splenomegaly, low total leucocyte counts, low platelets, high bilirubin, elevated aspartate aminotransferase, gamma-glutamyl transferase and international normalization ratio, low albumin, high AST to Platelet Ratio Index (APRI), and high BEA score. The splenic size, platelet count, and albumin levels were independently associated with cirrhosis (p < 0.001, <0.001, and 0.003). A model using a combination of platelet count, albumin, and spleen size was developed to accurately predict cirrhosis in this cohort. It had an area under the receiver operating characteristics (AUROC) of 0.935. Conclusions HDV-infected young adults, age 18-25 years, were at moderate to severe risk of disease progression. About one-third of patients had already developed cirrhosis indicating the aggressive nature of the disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Severity of Hepatitis D in Young Adults of Age 18-25 Years

Abbas

Qadeer

Mandviwalla

et al. 2020

Cureus

View full text Add to dashboard Cite

show abstract

“…Patients with HDV infection show HBsAg levels similar to HBV-monoinfected individuals but HBV DNA is frequently low or completely suppressed in hepatitis D 7. Subsequently, vertical transmission of HDV occurs infrequently8 and the majority of patients have therefore acquired HDV infection during childhood. At least eight different HDV genotypes are known with distinct global distributions.…”

mentioning

confidence: 99%

Devil hepatitis D: an orphan disease or largely underdiagnosed?

Wedemeyer

Negro

2018

Gut

View full text Add to dashboard Cite

“…These two age groups were categorized into four main compartments, (i) susceptible individuals; (ii) HBV mono-infected individuals, (iii) HBV-HDV co-infected individuals, and (iv) recovered individuals who are immune to future mono- and co-infections. Both mono- and co-infected women transmit HBV infection perinatally but not HDV [ 26 ]. If vaccinated at birth, newborns acquire immunity against HBV and HDV.…”

Section: Methodsmentioning

confidence: 99%

Screening for hepatitis D and PEG-Interferon over Tenofovir enhance general hepatitis control efforts in Brazil

Goyal

Romero-Severson

2018

PLoS ONE

View full text Add to dashboard Cite

BackgroundHepatitis D virus (HDV), which requires the presence of hepatitis B virus (HBV), is a deadly yet neglected disease that rapidly leads to liver cancer and disease-induced mortality. This co-dependence creates complex transmission dynamics that make it difficult to predict the efficacy of interventions aimed at HBV and/or HDV control in endemic regions, such as certain municipalities of Brazil, where up to 65% of HBV-infected persons are co-infected.MethodologyWe created a mathematical model that captures the joint transmission dynamics of HBV and HDV, incorporating mother-to-child, sexual and household transmission. With an aim to minimize the number of total infections and disease-induced mortality in 2027, we then determined optimal strategies for Brazil and its sub-regions under a constrained budget, which was dynamically allocated among HBV and HDV screening, HBV and HDV treatment, HBV newborn and adult vaccination, and awareness programs. Three treatment options were considered, namely: Tenofovir, PEGylated-Interferon, and nucleic acid polymers (NAP).ResultsThe additional cost of HDV screening and the use of a more expensive PEGylated-Interferon are offset by not wasting resources on treating co-infected persons with Tenofovir. The introductory price of NAP treatment must be less than $16,000 per course to become competitive with Tenofovir and PEGylated-Interferon in Brazil.ConclusionAdditional screening for HDV is beneficial, even in a low HBV and HDV endemic regions of Brazil. We recommend PEGylated-Interferon, wherever possible, for both HBV and HDV. If PEGylated-Interferon is not available in abundance, PEGylated-Interferon for co-infections and 4-year Tenofovir treatment for mono-infections is recommended.

show abstract

Hepatitis B Virus‐Hepatitis D Virus mother‐to‐child co‐transmission: A retrospective study in a developed country

Abstract: These results suggest that HBV/HDV MTC co-transmission is exceptional. Studies are needed, mainly in developing countries.

Cited by 41 publications

References 15 publications

The Severity of Hepatitis D in Young Adults of Age 18-25 Years

The Severity of Hepatitis D in Young Adults of Age 18-25 Years

Devil hepatitis D: an orphan disease or largely underdiagnosed?

Screening for hepatitis D and PEG-Interferon over Tenofovir enhance general hepatitis control efforts in Brazil

Contact Info

Product

Resources

About