Hepatitis B Virus (HBV) Infection and Recombination between HBV Genotypes D and E in Asymptomatic Blood Donors from Khartoum, Sudan

Mahgoub, S.O.; Candotti, Daniel; Ekiaby, Magdy El; Allain, Jean Pierre

doi:10.1128/jcm.00867-10

Cited by 60 publications

(89 citation statements)

References 33 publications

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“…This result is high than a study carried out in Khartoum State for blood samples of donors where positive anti-HB core and positive HBsAg were 36% and 11% respectively (Mahgoub et al, 2011). The study among donors is selective and purposive compared to our study where sampling procedure infers the prevalence of HBV markers for White Nile State.…”

Section: Discussioncontrasting

confidence: 44%

“…The infectivity of HBV is 50 to 100 times higher than HIV (WHO, 2012). Internationally; HBV is a leading cause of morbidity and mortality in the presence of the era of vaccines and antiviral treatment (Mahgoub, Candotti, El-Ekiaby, & Allain, 2011). Health-care workers are having the highest probability of being infected with HBV during medical career in health institutions (Deuffic-Burban, Delarocque-Astagneau, Abiteboul, Bouvet, & Yazdanpanah, 2011;Mele et al, 2001;De Schryver, Claesen, Meheus, van Sprundel, & François, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Conditional Probabilities of HBV markers among Health Care Workers in Public Hospitals in White Nile State, Sudan; 2013

Elmukashfi¹,

Balla²,

Bashir³

et al. 2016

GJHS

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Background: Health-care workers are having highest probability of being infected with HBV.Objective: To determine conditional probability of sero-prevalence of hepatitis B virus markers among health care workers in White Nile State, Sudan. Methods:A cross sectional study design with analytical approach was used. Three hundred eighty five health care workers were selected randomly. An interview was carried using a pre-tested questionnaire and five ml venous blood samples were consented. Blood samples were tested for Anti-HB core total, HBsAg and HBeAg. Conditional probabilities of being a carrier and highly infective were calculated regarding departments, occupation of HCWs, marital status and working duration in hospital.Results: Out of the total study population, 230 (59.7%) were positive for anti-HB core total. Out of 230 HCWs, 62 (27.1%) were positive for HBsAg. Out of 62 HCWs, 29 (46.8%) were positive for HBeAg. In overall, 16% of study population was carriers and 7.5% were highly infective. HCWs in surgical and Obstetrics & gynaecology had 0.50 conditional probability of being carriers and highly infective. Laboratory technicians had 0.64 conditional probability of being carriers and highly infective. HCWs with working duration in hospitals up to 5 years had 0.63 probability of being carriers and highly infective. Conclusion:Prevalence and conditional probabilities of HBV markers among health care worker in White Nile State were high. HCWs in Surgical and Obstetrics & gynaecology, Laboratory technicians and HCWs with working duration up to 5 years are carriers and highly infective. Periodical screening and vaccination of HCWs are recommended.

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Section: Discussioncontrasting

confidence: 44%

Section: Introductionmentioning

confidence: 99%

Conditional Probabilities of HBV markers among Health Care Workers in Public Hospitals in White Nile State, Sudan; 2013

Elmukashfi¹,

Balla²,

Bashir³

et al. 2016

GJHS

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“…OHB'li hastalarda genotip D'nin daha sık olduğunu gösteren ça-lışmalar olsa da farklı sonuçlar elde edilen çalışmalar da mevcuttur. [6][7][8][9][10]21]. Yapılan bazı çalışmalarda ise özellikle seronegatif OHB oluşumunda HBV X geninde mutasyonların etkisini düşündüren sonuçlar elde edilmiştir [38].…”

Section: Patogenez Ve Klinikunclassified

“…Pencere dönemi dışında HBsAg negatif iken HBsAg'ye karşı antikor (antiHBs) veya Hepatit B Core antijenine karşı immünglo-bülin G yapısında antikor (antiHBc IgG) varlığında veya yokluğunda, kan veya dokularda HBV DNA varlığı OHB olarak adlandı-rılır. OHB'li hastalarda serum HBV DNA düzeyi ise genellikle 10 4 kopya/ml'den düşük saptanır ve bu düzey HBsAg pozitif kişilere göre anlamlı olarak düşüktür [3,[6][7][8][9][10][11][12].…”

Section: Introductionunclassified

Occult Hepatitis B Virus Infection

2013

Ann Clin Anal Med

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“…Internationally, HBV is at the top of other diseases regarding morbidity and mortality [1]. HBV is highly infectious.…”

Section: Background Informationmentioning

confidence: 99%

Probability of HBsAg Among Village Midwives in Khartoum State, Sudan, 2014

Elsheikh¹,

Swait²,

Balla³

et al. 2017

SJPH

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Abstract:The risk of catching HBV infection varies between and in-between health institutions as well as at geographical areas for general population. An observational study was performed in order to determine the conditional probabilities of the prevalence of HBsAg among Village Midwives in Khartoum State, Sudan, 2014. Through one stage stratified, systematic random sampling three hundred and thirty five village midwives out of 1848 were selected. A close end questionnaire for demographic data was used. Using Eliza, blood was tested; sera of all participants were examined for Anti-HBcore (IgG and IgM). Positive specimens for Anti-HBcore and HBsAg were examined for HBsAg and HBeAg respectively. Statistical package of social sciences (SPSS) version (16) and Chi-square test were used. P ≤ 0.05 was considered statistically significant. Probability was calculated manually using Bayesian analysis method. Participants were divided into three main age groups: (i) Age group less than 30 years (4.6%). (ii) Age group (30-49) represented by 65.8%. (iii) Age group more than 50 years (29.5%). For education (0.9%) university graduate, (9.8%) secondary certificate, (14.2%) intermediate, (50.2%) primary, (1.9%) Quranic School and (23%) were illiterate. About (61.8%) were married, (16.4%) widow, (11.3%) divorced and (4.8%) un-married. Thirty four percent of them were positive for Anti-HBcore (IgG) indicating past or on going infection. Out of these fifty seven percent were HBsAg positive. HBeAg and Anti-HBcore (lgM) were negative. The maximum conditional probabilities of positive HBsAg in relation to age, educational level, marital status, and duration of work was found to be: (0.576), (0.524), (0.676), and (0.633) respectively. While the overall conditional probability in relation to these factors was: (0.576), (0.451), (0.14), and (0.633). Conditional probabilities of positive HBsAg among village midwives in Khartoum State, Sudan, were high. Village midwives with duration of work for 1-2 years and age above 50 years have got high probability of positive HBsAg. Screening and vaccination of village midwives are recommended.

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Hepatitis B Virus (HBV) Infection and Recombination between HBV Genotypes D and E in Asymptomatic Blood Donors from Khartoum, Sudan

Cited by 60 publications

References 33 publications

Conditional Probabilities of HBV markers among Health Care Workers in Public Hospitals in White Nile State, Sudan; 2013

Conditional Probabilities of HBV markers among Health Care Workers in Public Hospitals in White Nile State, Sudan; 2013

Occult Hepatitis B Virus Infection

Probability of HBsAg Among Village Midwives in Khartoum State, Sudan, 2014

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