Hepatitis B virus genotypes, subgenotypes, precore, and basal core promoter mutations in the two largest provinces of Pakistan

Ahmed, Choudhary Shoaib; Wang, Zhanhui; Zhou, Bin; Chen, Jinjun; Kamal, Mustafa; Hou, Jinlin

doi:10.1111/j.1440-1746.2008.05642.x

Cited by 17 publications

(16 citation statements)

References 25 publications

(51 reference statements)

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“…Genotype A was found to be the second more prevalent single genotype infection with 7.7 %. Genotype A was also reported in most of the previous studies [5, 18, 30, 32, 34, 39] in different proportions ranging from 0.8 to 21.4 % and a mean prevalence of 11.7 % (Table 4). Genotype B was present only in 0.6 % of present study samples while it was reported in proportions ranging from 18 to 24.5 % by previous studies from Pakistan [18, 30, 34].…”

Section: Discussionsupporting

confidence: 76%

“…The remaining six studies [5, 31, 32, 37–39] reported genotype D as the commonest one in Pakistan with percentage distribution of 59, 84, 70, 98.2, 84 and 93.2 % respectively (Table 4). The results of present study representing all parts of the country with significant number of samples is in agreement with the later group [5, 31, 32, 37–39] that reported genotype D as the most prevalent HBV genotype in Pakistan. Genotype A was found to be the second more prevalent single genotype infection with 7.7 %.…”

Section: Discussionmentioning

confidence: 99%

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Distribution and clinical significance of hepatitis B virus genotypes in Pakistan

et al. 2016

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BackgroundHepatitis B virus (HBV) genotype and its role in disease progression and patients’ response to antiviral treatment, is not well studied in Pakistan. This comprehensive study was aimed to determine the distribution of HBV genotypes in Pakistan and their possible association with phases of HBV infection.MethodsA total of 840 HBsAg positive samples was collected and tested for HBV DNA quantity. Samples below 100 IU/ml were excluded from the study. A total of 715 samples representing all the six parts of the country were genotyped by type specific primer PCR method. Clinical data of only 384 patients was compared as the remaining 332 were either receiving antiviral treatment or their infection phase was not confirmed.ResultsGenotype D was found in 509 samples (71.2 %), genotype A in 55 samples (7.7 %) and mixed infection with genotypes A and D in 124 samples (17.3 %). Genotypes B, C and E were identified in less than 1 % of the total samples. Genotype A, D and their mixture (A + D) were compared for severity of HBV infection. Significant differences were not found in distribution of HBV genotypes among different disease stages.ConclusionHBV genotype D was the predominant infection in all study areas of Pakistan followed by mixed genotypes infection (A + D) whereas genotype A has 10 times lower prevalence than genotype D. Genotypes B, C, E and F altogether make only 1.5 % of the prevalence. Genotype do not appears to show the severity of liver disease.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Distribution and clinical significance of hepatitis B virus genotypes in Pakistan

et al. 2016

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“…Sayıca fazla örnekte tespit edilemediği için, viral yük ve HBeAg ekspresyonu ile arasındaki ilişki gösterilememiştir. Bu 8 bç'lik delesyon mutasyonu, ülkemizde Bozdayı ve arkadaş-ları 36 tarafından dört hastada tespit edilmiş olup, Hindistan'da 24 bir, İran'da 41 dört ve Pakistan'da 42 da dört hastada bildirilmiştir. Çok sık rastlanmayan bu delesyon mutasyonlarının; virusun davranışına, moleküler patolojisine ve immün yanıt üzerine olan etkisinin, daha ileri in vitro çalışmalar ile aydınlatılmasına ihtiyaç duyulmaktadır.…”

Section: Mi̇krobi̇yoloji̇ Bülteni̇unclassified

Characterization of Basal Core Promoter/Precore Gene Mutations in Chronically Infected Patients with Hepatitis B Virus Genotype D in Mersin Province, Turkey

Tezcan¹,

Ülger²,

Üçbilek³

et al. 2015

Mikrobiyol Bul

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“…The D1 subgenotype was prevalent followed by D2, C2 subgenotypes. 5 Genotype D (subgenotypes D1 and D3) was the most prevalent genotype followed by genotypes A and a mixture of A and D (AD) in Pakistani HBV strains. 16 Genotype D appeared to be the dominant genotype among females in Karachi, Pakistan.…”

mentioning

confidence: 99%

Genetic Diversity of HBV Genotypes/ Subgenotypes and Their Correlation with Disease Progression

Kumar¹,

Singh²

2011

Euroasian Journal of Hepato-Gastroenterology

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Hepatitis B virus (HBV) infection remains a global health problem and a public health threat in the present era. It is estimated that 2 billion people are infected with HBV and 350 million people suffer from chronic HBV infection in the world. India is a prosperous country in Asia and has peculiar geographical presence which is responsible for evasion of this land by traders and invaders in past and resulted in gene influx due to invasion and/or anthropological migrations in the past. Moreover, recent increase in trade, trafficking and use of illicit drugs has also considerably influenced the epidemiology of HBV in different parts of India. However, data on the genotypes/subgenotypes diversity of HBV in India is scanty. In this manuscript, the information available on the genetic diversity of HBV genotypes and subgenotypes in India and in world and their relationship with the disease progression has been reviewed.

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Hepatitis B virus genotypes, subgenotypes, precore, and basal core promoter mutations in the two largest provinces of Pakistan

Abstract: Genotype D subtype D1 is the most prevalent HBV strain in Pakistan with 8-bp deletion mutants the most common in HBV carriers.

Cited by 17 publications

References 25 publications

Distribution and clinical significance of hepatitis B virus genotypes in Pakistan

Distribution and clinical significance of hepatitis B virus genotypes in Pakistan

Characterization of Basal Core Promoter/Precore Gene Mutations in Chronically Infected Patients with Hepatitis B Virus Genotype D in Mersin Province, Turkey

Genetic Diversity of HBV Genotypes/ Subgenotypes and Their Correlation with Disease Progression

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