Hepatitis B virus genotypes and subgenotypes and the natural history and epidemiology of hepatitis B

Reuter, Tânia; Gomes‐Gouvêa, Michele Soares; Chuffi, Samira; Duque, Ulisses H.; Carvalho, José Americo; Perini, Waltesia; Queiroz, Marcello Moro; Segal, Ingrid Marques; Azevedo, Raymundo Soares; Pinho, João Renato Rebello

doi:10.1016/j.aohep.2021.100574

Cited by 12 publications

(14 citation statements)

References 22 publications

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“…These genotypes are rarely detected or detected in low frequencies in our region, so it is inferred that they do not have characteristics of high transmissibility among our population, or have evolutionary disadvantages compared to the two preponderant genotypes F and A. Various studies have shown the existence of dissimilar characteristics between the different viral genotypes, in relation to the clinical course, HBV viral load, and, particularly, to the HBeAg seroconversion rate (41)(42)(43). In our study we only found that individuals infected with genotype A presented a significantly higher HBV viral load than those infected with genotype D among CHB patients.…”

Section: Acute Hepatitis B (Ahb)mentioning

confidence: 95%

Acute and chronic HBV infection in central Argentina: High frequency of sub-genotype F1b, low detection of clinically relevant mutations and first evidence of HDV

et al. 2023

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IntroductionGenomic analysis of hepatitis B virus (HBV) identifies phylogenetic variants, which may lead to distinct biological and clinical behaviors. The satellite hepatitis D virus (HDV) may also influence clinical outcomes in patients with hepatitis B. The aim of this study was to investigate HBV genetic variants, including clinically relevant mutations, and HDV infection in acute and chronic hepatitis B patients in central Argentina.MethodsA total of 217 adult HBV infected patients [acute (AHB): n = 79; chronic (CHB): n = 138] were studied; 67 were HBV/human immunodeficiency virus (HIV) coinfected. Clinical and demographic data were obtained from medical records. Serological markers were determined. Molecular detection of HBV and HDV was carried out by RT-Nested PCR, followed by sequencing and phylogenetic analysis.ResultsOverall, genotype (gt) F [sub-genotype (sgt) F1b] was the most frequently found. In AHB patients, the gts/sgts found were: F1b (74.7%) > A2 (13.9%) > F4 (7.6%) > C (2.5%) > A1 (1.3%). Among CHB patients: F1b (39.1%) > A2 (23.9%) > F4 (18.2%) > D (9.4%) > C and F6 (3.6% each) > A1, A3 and B2 (0.7% each). The distribution of sgt A2 and gt D was significantly different between HBV mono and HBV/HIV coinfected patients [A2: 15.9% vs. 35.7% (p < 0.05), respectively and D: 14.6% vs. 1.8% (p < 0.05), respectively]. Mutation frequency in basal core promoter/pre-Core (BCP/pC) region was 35.5% (77/217) [AHB: 20.3% (16/79), CHB: 44.2% (61/138)]. In the open reading frame (ORF) S, mutations associated with vaccine escape and diagnostic failure were detected in 7.8% of the sequences (17/217) [AHB: 3.8% (3/79), CHB: 10.1% (14/138)]. ORF-P amino acid substitutions associated with antiviral resistance were detected in 3.2% of the samples (7/217) [AHB: 1.3% (1/79), CHB 4.3%, (6/138)]. The anti-HDV seropositivity was 5.2% (4/77); one sample could be sequenced, belonging to gt HDV-1 associated with sgt HBV-D3.DiscussionWe detected an increase in the circulation of genotype F in Central Argentina, particularly among AHB patients, suggesting transmission advantages over the other genotypes. A low rate of mutations was detected, especially those with antiviral resistance implications, which is an encouraging result. The evidence of HDV circulation in our region, reported for the first time, alerts the health system for its search and diagnosis.

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Section: Acute Hepatitis B (Ahb)mentioning

confidence: 95%

Acute and chronic HBV infection in central Argentina: High frequency of sub-genotype F1b, low detection of clinically relevant mutations and first evidence of HDV

et al. 2023

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“…Comparativamente com dados nacionais, também se observou a maior dificuldade na definição da transmissibilidade, sendo a forma "desconhecida" de maior prevalência em ambos os grupos, seguido pela forma "vertical/intrafamiliar", o que difere do último boletim epidemiológico nacional, que identifica a via sexual como a segunda via de transmissão mais frequente 15,16 . Isso reforça a importância da investigação epidemiológica sistematizada como a realizada por Reuter e col. 4 para melhor direcionamento das políticas públicas.…”

Section: Métodos|unclassified

“…Alguns indivíduos após infecção aguda por HBV evoluem com eliminação completa do vírus e adquirem imunidade, enquanto outros persistem com infecção crônica, a depender da resposta imune do hospedeiro 4 . O manejo clínico desta doença requer seguimento de longo prazo, com monitoramento da atividade viral e atividade inflamatória e/ou fibrose no fígado.…”

Section: Introdução|unclassified

Perfil epidemiológico e grau de fibrose em portadores crônicos do vírus da hepatite B

Sant’Ana¹,

Barille²,

Segal³

et al. 2023

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Introdução: A hepatite crônica pelo vírus da hepatite B pode evoluir com complicações graves, como cirrose e carcinoma hepatocelular. A avaliação da fibrose hepática pode ser realizada por métodos invasivos diretos (biópsia hepática) e indiretos (APRI/FIB-4). Objetivo: Descrever o perfil epidemiológico e analisar o grau de fibrose hepática em indivíduos com hepatite B crônica inativa (Grupo 1) e ativa compensada (Grupo 2). Métodos: Estudo transversal utilizando dados de 200 indivíduos com hepatite B crônica, entre março e agosto de 2022. Resultados: Dos 200 indivíduos, 65% eram portadores crônicos inativos e 35% eram ativos, HBeAg negativos. No primeiro, predominou-se o sexo feminino (54,6%), e no segundo, masculino (57,1%). Para ambos, a mediana de idade foi de 53,5 e maioria com etnia parda. Histórico de etilismo desconhecido foi mais frequente no Grupo 1 (54%), e ausente (51%) no Grupo 2. A média de TGO, TGP e plaquetas foi similar nos dois grupos (p= 0,48; 0,91; 0,59). A média de fibrose APRI foi de 0,32 nos dois grupos (p= 0,90). O FIB4 foi de 1,28/1,25 para ambos os grupos. A avaliação por ultrassonografia evidenciou normalidade em 60% dos dois grupos. Somente 0,8%/3,1% do Grupo 1 apresentavam APRI/FIB4 compatíveis com fibrose hepática avançada (F3-F4). No Grupo 2, evidenciou-se baixa frequência de hepatopatia avançada. Conclusão: O perfil epidemiológico e scores de fibrose em ambos os grupos foi similar. A perspectiva de interrupção do uso de antivirais pode ser uma alternativa futura.

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“…It is also well-known that infected people do not always show symptoms in the early stages, although, some may experience acute illness that lasts several weeks including Jaundice (yellowing of the skin and eye), dark urine, and extreme fatigue, nausea, vomiting, and some abdominal pains. Despite the above symptoms mentioned, symptoms exhibited by patients also depend on the status of the immune system of the patient, the age, and general health of the patient [17].…”

Section: Introductionmentioning

confidence: 99%

“…However, if one uses immune-suppressing drugs, the virus in your liver might be reactivated in the future [?]. HBV replicates only within the host cell since it lacks the enzymes necessary for protein and nucleic acid synthesis [17]. Chronic HBV infection occurs when the virus is still detectable six months after the infection, indicating that the virus has not been fully cleared by the immune system and is still present in the patient's blood and liver.…”

Section: Introductionmentioning

confidence: 99%

Stability Analysis of Caputo Fractional Order Viral Dynamics of Hepatitis B Cellular Infection

Opoku

Wiah

Sackitey

et al. 2022

Preprint

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Hepatitis B virus genotypes and subgenotypes and the natural history and epidemiology of hepatitis B

Cited by 12 publications

References 22 publications

Acute and chronic HBV infection in central Argentina: High frequency of sub-genotype F1b, low detection of clinically relevant mutations and first evidence of HDV

Acute and chronic HBV infection in central Argentina: High frequency of sub-genotype F1b, low detection of clinically relevant mutations and first evidence of HDV

Perfil epidemiológico e grau de fibrose em portadores crônicos do vírus da hepatite B

Stability Analysis of Caputo Fractional Order Viral Dynamics of Hepatitis B Cellular Infection

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