Hepatitis B Virus: From Diagnosis to Treatment

Güvenir, Meryem; Arıkan, Ayşe

doi:10.33073/pjm-2020-044

Cited by 27 publications

(11 citation statements)

References 60 publications

(71 reference statements)

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“…Hepatitis B virus (HBV) infection is a major global health problem with approximately 300 million chronic HBV-infected individuals worldwide [ 1 ]. It is associated with up to 900,000 deaths every year mostly due to cirrhosis and HCC [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Association of hepatitis B vaccine response to vitamin D supplementation and ultraviolet B (UVB) exposure during different time intervals in experimental animals

et al. 2022

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The implications of vitamin D deficiency on the immune system have become clearer in recent years, being associated with less immune response following HBV vaccine. We aimed to elucidate the effect of vitamin D supplementation and UVB exposure on short- and long-term performance of hepatitis B vaccine. Forty-five male rabbits were randomly divided into 3 groups that were immunized with recombinant HBsAg. The first group (group I) represented a negative control group, whereas group III rabbits were administered with commercially available 1,25 (OH)2 vitamin D as an alternative for UVB exposure in group II. Results showed that vitamin D concentrations were significantly higher in UVB exposed group compared to both negative control and vitamin D-supplemented groups during short- and long-time intervals. In addition, means of anti-HBsAg isotypes’ levels and anti-HBsAg IgG avidity% were significantly higher in negative control group compared to other groups during short- and long-time intervals. Moreover, vitamin D serum concentration was positively correlated with anti-HBsAg IgG level and avidity % in both negative control and vitamin D-supplemented groups, while it was negatively correlated with anti-HBsAg IgM level in negative control group. It can be concluded from the above results that UVB radiation may have both augmenting and suppressive effects and that circulating serum vitamin D concentration may have a positive association with premium immune modulation following HBV vaccination.

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Section: Introductionmentioning

confidence: 99%

Association of hepatitis B vaccine response to vitamin D supplementation and ultraviolet B (UVB) exposure during different time intervals in experimental animals

et al. 2022

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“…HBV causes acute and chronic liver disease and is endemic in many areas of the world. The virus is transmitted through contact with blood or other body fluids from an infected person (Guvenir and Arikan., 2020;Prifti et al, 2021). Polymerase chain reaction is one of the most powerful technologies in the molecular biology, was invented by Mullis in 1983 and patented in1985.…”

Section: Introductionmentioning

confidence: 99%

Applying RT-PCR standard detection procedures of HBV and HCV in Wasit blood bank

Alkhateeb¹,

Maleek²,

Faraj³

2022

ijhs

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Background: Blood and blood products are a unique and precious resource because they can be obtained only from individuals who donate blood or its components. Aim of the study: To increase the safety of blood given to patients by evaluating the addition of new investigations to detect HBV and HCV of donated blood in the blood bank. Patients and Methods: this study included 150 samples of blood taken from the blood bags of donors from the blood bank /Wasit Province. In this study used ELISA (as serological method) & RT-PCR (as molecular method) to detect infection with hepatitis B virus and hepatitis C virus. Results: The results of ELISA test, from 150 analyzed samples, only 6/150 (4.0%) of the patients were diagnosed infection by HCV and 1/150 (0.6%) infection by HBV. The results of PCR test, (4.0%) and (5.3%) for HCV C and HBV respectively. Conclusion: Diagnosis of hepatitis virus (B, C) by ELISA is still sufficient.

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“…In African and Western Pacific countries, 6.1% and 6.2% of the adult population, respectively, are infected with HBV [2]. In contrast, the prevalence of HBV infection in the European, South-East Asian, and Eastern Mediterranean countries is 1.6%, 2.0%, and 3.3%, respectively [3]. Therefore, the WHO has implemented an action plan to eradicate HBV by 2030, and this involves the identification of novel and alternative drugs against the disease.…”

Section: Introductionmentioning

confidence: 99%

Phytomedicines to Target Hepatitis B Virus DNA Replication: Current Limitations and Future Approaches

Sadiea

Sultana

Chaki

et al. 2022

IJMS

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Hepatitis B virus infection (HBV) is one of the most common causes of hepatitis, and may lead to cirrhosis or hepatocellular carcinoma. According to the World Health Organization (WHO), approximately 296 million people worldwide are carriers of the hepatitis B virus. Various nucleos(t)ide analogs, which specifically suppress viral replication, are the main treatment agents for HBV infection. However, the development of drug-resistant HBV strains due to viral genomic mutations in genes encoding the polymerase protein is a major obstacle to HBV treatment. In addition, adverse effects can occur in patients treated with nucleos(t)ide analogs. Thus, alternative anti-HBV drugs of plant origin are being investigated as they exhibit excellent safety profiles and have few or no side effects. In this study, phytomedicines/phytochemicals exerting significant inhibitory effects on HBV by interfering with its replication were reviewed based on different compound groups. In addition, the chemical structures of these compounds were developed. This will facilitate their commercial synthesis and further investigation of the molecular mechanisms underlying their effects. The limitations of compounds previously screened for their anti-HBV effect, as well as future approaches to anti-HBV research, have also been discussed.

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Hepatitis B Virus: From Diagnosis to Treatment

Cited by 27 publications

References 60 publications

Association of hepatitis B vaccine response to vitamin D supplementation and ultraviolet B (UVB) exposure during different time intervals in experimental animals

Association of hepatitis B vaccine response to vitamin D supplementation and ultraviolet B (UVB) exposure during different time intervals in experimental animals

Applying RT-PCR standard detection procedures of HBV and HCV in Wasit blood bank

Phytomedicines to Target Hepatitis B Virus DNA Replication: Current Limitations and Future Approaches

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