Hepatitis B virus evades the immune system by suppressing the NF-κB signaling pathway with DENND2A
Mayuko Ide,
Noriko Tabata,
Yuko Yonemura
et al.
Abstract:Overcoming hepatitis B virus (HBV) is a challenging problem because HBV deceives the host immune system. We have found that DENN domain-containing 2A (DENND2A) was essential for HBV maintenance, although its role remains unclear. In this study, we elucidate its function by screening a novel DENND2A-binding peptide, DENP4-3S. DENP4-3S exhibits homology to SAM and SH3 domain-containing protein 1 (SASH1), a scaffold protein involved in Toll-like receptor signaling that promotes proinflammatory cytokine production… Show more
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