Hepatitis B virus DNA is more powerful than HBeAg in predicting peripheral T-lymphocyte subpopulations in chronic HBV-infected individuals with normal liver function tests

You, Jun; Sriplung, Hutcha; Geater, Alan; Chongsuvivatwong, Virasakdi; Zhang, Lin; Chen, Hongying; Huang, Junhua; Tang, Bao-Zhang

doi:10.3748/wjg.14.3710

Cited by 12 publications

(12 citation statements)

References 39 publications

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“…Few studies have had the opportunity to evaluate the impact of HBsAg on the absolute CD4 count using a wide range of CD4 values as previous studies have assessed patients initiating antiretroviral therapy (usually with CD4 <200 cells/mm 3 ). Some of these studies have reported an association between HBsAg and CD4 count while others have not (13–15). However these previous studies have been focused on ART initiators which may mask an association between CD4 count and CH-B and are susceptible to confounding by an unmeasured factor influencing both CH-B risk and timing of presentation for antiretroviral therapy.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and associations with hepatitis B and hepatitis C infection among HIV-infected adults in South Africa

et al. 2012

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We assessed prevalence and factors associated with hepatitis B in a cross-section of HIV-infected primary care and anti-natal clinic patients in South Africa and evaluated a rapid hepatitis B surface antigen (HBsAg) assay. We enrolled 998 patients; 88% were women, median age was 29 years, and median CD4 count was 354 cells/mm3. HBsAg ELISA, anti-hepatitis B core (HBc) antibodies, and hepatitis C virus antibody were positive among 4.2%, 37%, and 0.1% of subjects, respectively. Univariate and multivariate associations were assessed using logistic regression. Anti-HBc antibodies were associated with alcohol use, traditional medicines, and higher CD4. HBsAg positivity was associated with lower CD4. Compared to the HBsAg ELISA, a rapid HBsAg test had a sensitivity of 75.0% and specificity of 99.6%. In conclusion, we identified a moderate prevalence of both HBsAg and anti-HBc. Importantly, we found subjects with HBsAg positivity had lower CD4 counts.

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Section: Discussionmentioning

confidence: 99%

Prevalence and associations with hepatitis B and hepatitis C infection among HIV-infected adults in South Africa

et al. 2012

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“…A few studies on HBV mono-infection support the hypothesis that HBV is associated with lower CD4+ T-cell counts. In a Thai study, HBV mono-infected individuals had lower CD4+ T-cells compared to HBsAg-negative subjects [13]; this association was strongest in those with high HBV DNA, detectable HBeAg, and HBV infection before the age of 20. A study of pregnant Indian women found that CD4+ T-cell counts were lower in 25 women with HBsAg compared to nearly 1,100 women without HBsAg [14].…”

Section: Discussionmentioning

confidence: 99%

Impact of Hepatitis B Virus Infection on Human Immunodeficiency Virus Response to Antiretroviral Therapy in Nigeria

et al. 2009

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Background As HAART is introduced into areas of the world with high hepatitis B virus (HBV) endemicity, it is important to determine the influence of HBV on HIV-HBV co-infected persons receiving antiretroviral therapy (ART). Methods We studied 1,564 HIV-infected subjects in Jos, Nigeria who initiated ART. HIV-HBV co-infected participants had HBeAg and HBV DNA status determined. CD4+ T-cell count and HIV viral load at ART initiation were compared between HIV mono-infected and HIV-HBV co-infected subjects using univariate methods. Regression analyses were used to determine if HBeAg status or HBV DNA at ART initiation were associated with baseline HIV parameters or ART response. Results The CD4+ T-cell counts of the 262 (16.7%) HIV-HBV co-infected participants was 107 cells/mL compared to 130 cells/mL in HIV monoinfected participants (p <0.001) at ART initiation. HIV-HBV co-infected participants also had higher HIV viral loads than HIV monoinfected subjects (4.96 vs. 4.75 log10 copies/mL; p = 0.02). Higher HBV DNA and detectable HBeAg were independently associated with lower CD4+ T-cell counts at ART initiation but not with higher HIV viral load. In a multivariable model, HBeAg-positive subjects were less likely to suppress HIV replication to ≤400 copies/ml (OR 0.54, p=0.03) at 24 weeks, but they had similar CD4+ T cell increases. At 48 weeks, there was no significant effect of HBeAg status on ART response. Conclusions In HIV-infected Nigerian individuals, HBV co-infection, especially in those with high levels of HBV replication, was associated with lower CD4+ T-cell counts at ART initiation independent of HIV RNA level. Subjects with HBeAg positive status had a slower virological response to ART. Further work is needed to understand the effects of HBV on CD4+ T-cells.

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“…Thus, the patients infected with genotype C need to be carefully monitored to assess their future clinical outcomes. Particularly, sub-genotype C1 is documented to have an increased tendency for the development of cirrhosis and hepatocellular carcinoma (HCC), especially in patients over 50 years of age [43][44][45]. On the other hand, genotype B patients have higher rates of HBeAg seroconversion, and HCC has been detected in younger patients [43,[46][47].…”

Section: Discussionmentioning

confidence: 99%

Distribution of hepatitis B virus genotypes in general population of Myanmar via Nation wide study

Kyaw¹,

Lwin²,

Aye³

et al. 2020

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Background Hepatitis B virus (HBV) infection is a severe health concern worldwide. HBV is a DNA virus with a rapid rate of mutation. Based on the heterogeneity of the HBV nucleotide sequence, the HBV strains are divided into ten genotypes, A to J, with a characteristic geographical distribution. Identifying and tracking the changes of HBV genotypes is important in epidemiological and transmission studies, predicting the risk for the development of severe liver disease and response to antiviral treatment. The present study was conducted to detect HBV genotypes and sub-genotypes in general population of different states and regions in Myanmar. Methods A total of 5,547 general adult population who residing at seven states, seven regions and Nay Pyi Taw Union Territory were screened for Hepatitis B Surface antigen (HBsAg) by Immunochromatgraphic test (ICT) in 2015. Of 353 HBsAg positive samples, HBV DNA were detected by using polymerase chain reactions (PCR) targeting the DNA sequences encoding the Pre-S region. A total of 153 PCR positive samples were preceded for genotyping by partial genome sequencing of both directions. The resulting sequences were then edited, aligned and compared with reference sequences using National Centre for Biotechnology Information (NCBI) web based genotyping tool. Results Three HBV genotypes; HBV/ C, HBV/ D and HBV/ B were detected in Myanmar, in which genotype HBV/ C (66.7%) was the most prevalent genotype followed by HBV/ D (32%) and HBV/ B (1.3%) respectively. Sub-genotyping revealed a total of 7 sub-genotypes within genotypes B, C and D: two (B4 and B5) in HBV/ B, three (C1, C5 and C7) in HBV/C and two (D3 and D6) in HBV/ D. Conclusion Genotype HBV/C, sub-genotype C1 was the most predominant genotype distributed in all states and regions of Myanmar. This study was first report on Nation- wide distribution of HBV genotype and sub-genotypes in Myanmar and the findings will be a huge support for hepatitis disease surveillance programme which is the one of the National Priority Diseases in Myanmar.

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Hepatitis B virus DNA is more powerful than HBeAg in predicting peripheral T-lymphocyte subpopulations in chronic HBV-infected individuals with normal liver function tests

Cited by 12 publications

References 39 publications

Prevalence and associations with hepatitis B and hepatitis C infection among HIV-infected adults in South Africa

Prevalence and associations with hepatitis B and hepatitis C infection among HIV-infected adults in South Africa

Impact of Hepatitis B Virus Infection on Human Immunodeficiency Virus Response to Antiretroviral Therapy in Nigeria

Distribution of hepatitis B virus genotypes in general population of Myanmar via Nation wide study

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