Hepatitis B Virus Carriage among Students of a Nigerian Tertiary Institution: A Cohort of Eligible Blood Donors

Pennap, G. R. I.; Nwachukwu, Onyeka; Ishaleku, D.; Ombugadu, R.J.

doi:10.3923/rjmsci.2011.90.93

Cited by 12 publications

(24 citation statements)

References 2 publications

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“…This seroprevalence rate is lower than the 12.5% earlier reported amongst asymptomatic students in Ahmadu Bello University, Zaria (Main Campus) , 11.5% among students of Nasarawa State University, Keffi (Pennap et al, 2011) and 15.5% found among medical students of Usman Danfodio University, Sokoto (Alo et al, 2013). Also, 11.0% was reported among Makerere University Medical Student (Pido and Kagimu, 2005).…”

Section: Discussionmentioning

confidence: 51%

“…It is also very possible that other than HIV, many people may not be aware of other sexually transmitted viral infections and so continue to have unprotected sex with fellow HIV negative partners who might be chronic carriers of HBV. It has been noted that in Africa, more than half of the population become HBV infected during their life time and about 8% of the inhabitants become chronic carriers (Pennap et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Hepatitis B virus is 50-100 times more infectious than HIV and 10 times more infectious than hepatitis C virus and because it replicates profusely and produces high titer in the blood (10 8 -10 10 virions/mL) any parenteral or mucosal exposure to infected blood poses a high risk of HBV acquisition (Pennap et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, they also form the bulk of the group that is usually required when there is need for blood donation. Hepatitis B virus infection is widely referred to as a silent killer because many carriers do not realize they are carrying the virus within the sexually (Pennap et al, 2011) and hence fail to seek appropriate medical attention.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Seroprevalence of hepatitis B virus in a tertiary institution in North Western Nigeria

Isa¹,

Aminu²,

Abdullahi³

et al. 2015

Afr. J. Microbiol. Res.

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Hepatitis B virus (HBV) is endemic in sub-Saharan Africa. The study was conducted to determine the seroprevalence of HBV infection and the possible potential risk factors among students of Ahmadu Bello University, Zaria, Kaduna State, Nigeria. A cross-sectional study was conducted between April and August, 2013. Structured questionnaires were administered to obtain socio demographic data and possible risk factors that might be associated with the viral infection. Blood samples were collected at the University Health Services (UHS) from 600 consenting consecutive students aged between 16 and 40 years old. The sera were screened for HBsAg using device kit and anti-HBs, HBeAg, anti-HBe and anti-HBc using one-step cassette style diagnostic kits. Reactive sera for HBsAg were further confirmed using ELISA kits. Of the 600 students tested for HBsAg, 9.2% (55/600) tested positive among which, none had detectable anti-HBs antibodies, indicating recent infection. About 7.3, 36.4 and 94.5% were positive for HBeAg, anti-HBe and anti-HBc respectively. There was a significant association between age group, gender, family history of the students and HBV infection (P=0.016, 0.049 and 0.000, respectively). Other risk factors studied were not significantly associated with the viral infection. The seroprevalence of 9.2% for HBsAg obtained in this study indicates high endemicity according to WHO classification. Four of the students were highly infectious. The study indicates that close contact among family members and economic disadvantages of some of the students might be predisposing factors to the infection. More than half of the students were ignorant about HBV.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Seroprevalence of hepatitis B virus in a tertiary institution in North Western Nigeria

Isa¹,

Aminu²,

Abdullahi³

et al. 2015

Afr. J. Microbiol. Res.

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show abstract

“…4 However, 80% of countries identifies hepatitis as an urgent public health problem. 4 Hepatitis B Virus infection is widely referred to as a silent killer because many carriers do not realize they are carrying the virus 5 and hence fail to seek appropriate medical attention, therefore posed a high risk to its victim. It has been estimated that about 2 billion people have been infected with hepatitis B virus and 350 million have chronic lifelong infection.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Hepatitis B Virus and Human Immunodeficiency Virus infection among students in Ahmadu Bello University, Zaria, Nigeria

Isa¹,

Aminu²,

Abdullahi³

et al. 2017

Arch Med Biomed Res

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Hepatitis B virus (HBV) and Human Immunodeficiency Virus (HIV) are endemic in sub-Saharan Africa. Evidence on HBV co-infection rates with HIV infection among individuals remains conflicting. The study was conducted to determine the seroprevalence of HBV and HIV infections and the possible potential risk factors among students of Ahmadu Bello University (ABU), Zaria, Nigeria. Blood samples were collected from 600 consenting consecutive students aged between 16 and 40 years old at the University Health Services, ABU, Zaria. The sera were screened for HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc using diagnostic kits and for Human Immunodeficiency Virus using Determine TM HIV-1/2 kits. Reactive sera for HBsAg were further confirmed using ELISA kits. For HBsAg, 9.2% (55/600) tested positive among which, none had detectable anti-HBs antibodies, indicating recent infection. About 7.3%, 36.4% and 94.5% were positive for HBeAg, anti-HBe and anti-HBc respectively. Seroprevalence of HIV infection was 2.8% (17/600). One (0.2%) of the student was infected with both HBV and HIV. There was a significant association between age group (p=0.016), gender (p=0.049), family history of HBV infection (p=0.000), and seroprevalence of HBsAg. While for HIV, only menial jobs (p = 0.001) was significantly associated with the infection. The results showed close contact among family members to be a predisposing factor to these viral infections. A total of 314 students were ignorant of HBV and four of them were infectious. The seroprevalence of HBsAg obtained in this study indicates high endemicity according to WHO classification. However, seroprevalence of HIV and its co-infection rate with HBV were very low. This was encouraging and it indicates that the campaign on HIV is yielding the desired result. Therefore similar campaign should be extended to Hepatitis B.

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Markers of hepatitis B virus infection in a subset of young people in central Nigeria

et al. 2019

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Hepatitis B Virus Carriage among Students of a Nigerian Tertiary Institution: A Cohort of Eligible Blood Donors

Cited by 12 publications

References 2 publications

Seroprevalence of hepatitis B virus in a tertiary institution in North Western Nigeria

Seroprevalence of hepatitis B virus in a tertiary institution in North Western Nigeria

Seroprevalence of Hepatitis B Virus and Human Immunodeficiency Virus infection among students in Ahmadu Bello University, Zaria, Nigeria

Markers of hepatitis B virus infection in a subset of young people in central Nigeria

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