Hepatitis B virus and hepatitis C virus co-infection in hemodialysis patients: A retrospective study from a tertiary care hospital of North India

Malhotra, Rubina; Soin, Divya; Grover, Pragati; Galhotra, Shipra; Khutan, Himanshu; Kaur, Navneet

doi:10.4103/0976-9668.175076

Cited by 38 publications

(15 citation statements)

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“…An additional study done in Cameroon reported that the frequency of HBs Ag and HCV Abs infections in HD patients was 10.6% and 19.2%, respectively [ 20 , 21 ]. In India, out of 262 patients, 88 (33.5%) were found to be having HCV infection, 4 (1.5%) were found to be positive for HBsAg and dual infection was observed in 2 (0.8%) patients [ 22 , 23 ]. The lower occurrence of HBV in this study may be caused by sample size, the method used for detection the virus, less blood transfusion and, blood products for the patients and screening of blood for blood-borne viral infections before transfusion.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence occurrence of viral hepatitis and HIV among hemodialysis patients

Kamal

Mahdi

2018

Annals of Medicine and Surgery

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BackgroundPatients with chronic renal failure (CRF) were on maintenance invasive hemodialysis (HD) procedure. This procedure by itself affects immunity of the patients and became more susceptible to viral infections.Aim of the studyto investigate the occurrence of HBV, HCV and HIV infections in patients with hemodialysis.Patients and methodsA retrospective study of 430 end-stage renal failure patients, referred to hemodialysis department at XXXX Teaching Hospital, Baghdad-Iraq from January-2015 to January-2017. Patients were investigated for HBs-Ag using enzyme-labeled antigen test (Foresight-EIA-USA), HCV- Abs (IgG) specific immunoglobulin using an HCV enzyme-labeled antigen test (Foresight-EIA-USA)and anti - HIV Abs (IgG) using enzyme-labeled antigen test (Foresight-EIA-USA).ResultsThe frequency of HBV infection in the first year was not significant between males (1.11%) and females (0.00%) (P = 0.295). About HCV also there are no significant differences between males (12.63%) and females (9.31%) (P = 0.347). After one year of follow up the frequencies of HBV and HCV were not significant between two sexes. Additionally, no any one of the patients had HIV infection.ConclusionsThis study brings a light on that HBV and HCV were having the same frequencies in both genders and lower occurrence with time. Furthermore, HIV was not detected in those patients.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence occurrence of viral hepatitis and HIV among hemodialysis patients

Kamal

Mahdi

2018

Annals of Medicine and Surgery

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“…Age and gender are also touted as risk factors for HCC [6]. Among of these risks, HBV and HCV infection constitute a serious public health challenge with approximately 400 and 170 million people with chronic HBV or HCV infection worldwide, respectively [7]. It is estimated that 75% of all HCC cases are due to chronic infection with HBV or HCV [7].…”

Section: Introductionmentioning

confidence: 99%

“…Among of these risks, HBV and HCV infection constitute a serious public health challenge with approximately 400 and 170 million people with chronic HBV or HCV infection worldwide, respectively [7]. It is estimated that 75% of all HCC cases are due to chronic infection with HBV or HCV [7]. The Asia Pacific region has the largest share of HBV and HCV in the world, with ~74% of global liver cancer-specific deaths occurring in Asia [7].…”

Section: Introductionmentioning

confidence: 99%

Collagen 1A1 (COL1A1) Is a Reliable Biomarker and Putative Therapeutic Target for Hepatocellular Carcinogenesis and Metastasis

Chang

Bamodu

et al. 2019

Cancers

151

113

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Increasing evidence shows that hepatocellular carcinoma (HCC) is a principal cause of cancer-related mortality globally, especially among Asian and African populations. Collagen type I α1 (COL1A1) is the major component of type I collagen. While aberrant expression of COL1A1 and COL1A2 is implicated in numerous cancers, the differential role of COL1A1 in malignant, premalignant and normal tissues remains unclear, and its clinical significance in HCC has not been elucidated. In this study, using bioinformatics analysis of publicly-available HCC microarray data from Gene Expression Omnibus (GEO) and RNAseq data from The Cancer Genome Atlas (TCGA) database, we determined that COL1A1 is significantly upregulated in HCC tumor tissues in comparison to normal tissues. Our analysis also revealed that COL1A1 confers survival advantage and enhanced oncogenicity on HCC cells. Interestingly, the siRNA-mediated silencing of COL1A1 expression (siCOLIA1) suppressed HCC cells clonogenicity, motility, invasiveness and tumorsphere formation. Concomitantly, siCOL1A1 abrogated Slug-dependent epithelial-to-mesenchymal transition (EMT) and HCC stemness gene-signature, by attenuating expression of stemness markers SOX2, OCT4 and CD133. The present study provides some mechanistic insight into COL1A1 activity in HCC and highlights its putative role as an important diagnostic biomarker and potential therapeutic target in early development and metastasis of HCC.

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“…Studies on the prevalence of HCV and HBV infection in HD are rare; Kara et al, 17 in Turkey reported a dual incidence of three out of 67 paralysis patients. Hong et al, 18 in China reported a common infection of 30.4% and was higher than dialysis patients who had only 3.8%.…”

Section: Discussionmentioning

confidence: 99%

Explosion of Hepatitis B and C Viruses Among Hemodialysis Patients as a Result of Hemodialysis Crisis in Yemen

et al. 2019

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The United Nations considers the situation in Yemen to be the worst humanitarian crisis in the world. In the midst of this, the fastest-spreading viral infection among HD patients was recorded. Therefore, this cohort study based in HD unit was conducted in Dhamar Hospital to estimate the outbreak of hepatitis B and C viruses among dialysis patients during the dialysis crisis in Yemen. All the patients who continuous go through hemodialysis from January 2018 to December 2018 and they were free from HBV/HCV infections at the start of the study (January 2018) were included. Patients who were discontinued from dialysis before the end of the year due to death or relocation were excluded from the study. Patients were tested for anti-HCV antibodies and hepatitis B surface antigen (HBsAg) at study start (January 2018) then at the end of the follow up (December 2018). The individual’s data were collected in a pre-designed questionnaire including; demographic data of HD frequency, and laboratory results. The study included 202 patients, 20 (9.9%), 18 (8.9%) and 6 (2.97%) were found to be infected with HCV, HBV and Co-HBV/HCV infection respectively. There was significant association between rise of HCV rate and younger patient age, and high frequency of dialysis. In conclusion, the prevalence of HBV and HCV infection and HBV / HCV infection in hemodialysis patients in our surroundings one year after HD was extremely common and lead to disaster for HD patients. This catastrophe is due to the lack or limited availability of materials and tools for dialysis and laboratory materials for virus tests due to the unfair siege on Yemen from Saudi Arabia and the United Arab Emirates and the closure of Sana'a airport, which is the only entrance to medicines. Peer Review History: UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 8.5/10 Reviewer(s) detail: Name: Dr. Mohammed Sadeg Abdullah Al-Awar Affiliation: Physiology & Histopathology Queen Arwa University and Amran University, Yemen E-mail: momed.sadeg@gmail.com Name: Dr. Heba-Tallah Ahmed Mohamed Moustafa Affiliation: Heliopolis University Cairo, Egypt E-mail: anasweety2003@yahoo.com Comments of reviewer(s):

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Hepatitis B virus and hepatitis C virus co-infection in hemodialysis patients: A retrospective study from a tertiary care hospital of North India

Cited by 38 publications

References 11 publications

Seroprevalence occurrence of viral hepatitis and HIV among hemodialysis patients

Seroprevalence occurrence of viral hepatitis and HIV among hemodialysis patients

Collagen 1A1 (COL1A1) Is a Reliable Biomarker and Putative Therapeutic Target for Hepatocellular Carcinogenesis and Metastasis

Explosion of Hepatitis B and C Viruses Among Hemodialysis Patients as a Result of Hemodialysis Crisis in Yemen

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