Hepatitis B vaccination of newborn infants in rural China: evaluation of a village-based, out-of-cold-chain delivery strategy

Wang, Lixia; Li, Junhua; Chen, Haiping; Li, Fangjun; Armstrong, Gregory L.; Nelson, Carib; Ze, Wenyuan; Shapiro, Craig N.

doi:10.2471/blt.06.037002

Cited by 86 publications

(66 citation statements)

References 9 publications

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“…In other countries with a high number of unattended home births, successful strategies, such as the use of simple injection devices (e.g. Uniject) and the use of the vaccine in a controlledtemperature chain have been implemented to reach these infants [23][24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of chronic hepatitis B virus infection after implementation of a hepatitis B vaccination program among children in three provinces in Cambodia

Mao

Patel

Hennessey

et al. 2013

Vaccine

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Section: Discussionmentioning

confidence: 99%

Prevalence of chronic hepatitis B virus infection after implementation of a hepatitis B vaccination program among children in three provinces in Cambodia

Mao

Patel

Hennessey

et al. 2013

Vaccine

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“…Another important issue is the timely birth dose which should be given within 24 h after delivery, because a delay in this initial dose has been shown to lead to an increased risk of infection in children whose mothers are HBsAg carriers [85,86]. The heat stability of hepatitis B vaccines renders the administration of a timely birth dose feasible also in rural and remote areas [21,22,87,88].…”

Section: Post-exposure Settingsmentioning

confidence: 99%

Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B

Chen

2009

Journal of Hepatology

220

191

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Hepatitis B virus infection is a global health problem. Worldwide, about 360 million people are chronically infected with the virus. They continue to spread the virus to others and are themselves at risk of chronic liver diseases and hepatocellular carcinoma. The infection can now be treated by antivirals or interferons and the transmission route can be interrupted. Nevertheless, the most effective means is to immunize all susceptible individuals, especially young children, with safe and efficacious vaccines. The combined efforts of vaccination, effective treatment and interruption of transmission make elimination of the infection plausible and may eventually lead to eradication of the virus. Because hepatitis B vaccination has a key role in the control of hepatitis B, properties of this vaccine, its effectiveness in pre-exposure and post-exposure settings, duration of protection after vaccination and the need of booster doses are discussed. Mass hepatitis B vaccination in children decreases the carriage of the virus, and the diseases associated with acute and chronic infection, including hepatocellular carcinoma. Challenges that need to be solved to expand mass vaccination, and the strategies towards elimination and eventual eradication of hepatitis B in the world are also discussed.

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“…Not every health facility has a functional cold chain, and using hepatitis B vaccine in a controlled temperature chain, where vaccine is stored at ambient temperature for a defined period of time, could be an option for facilitating a timely birth dose in these facilities. 22,23 Improving health facility coverage to 100% will only affect the 52% of children born in health facilities. 24 Children born at home must be reached by improved timely postnatal outreach visits.…”

mentioning

confidence: 99%

Hepatitis B Surface Antigen Seroprevalence Among Children in Papua New Guinea, 2012–2013

Kitau¹,

Datta²,

Patel³

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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Abstract. Approximately 8% of the population in Papua New Guinea (PNG) has chronic hepatitis B virus (HBV) infection. To decrease the burden of chronic HBV infection, a national 3-dose infant hepatitis B vaccination program was implemented starting in 1989, with a birth dose (BD) added to the schedule in 1992. To assess the impact of the hepatitis B vaccination program, we conducted a serosurvey among children born after vaccine introduction. During 2012-2013, a cross-sectional stratified four-stage cluster survey was conducted to estimate hepatitis B surface antigen (HBsAg) prevalence among children 4-6 years of age. We collected demographic data, vaccination history, and tested children for HBsAg. Of 2,133 participants, 2,130 children had vaccination data by either card or recall: 28% received a BD; 81% received 3 vaccine doses. Of 2,109 children providing a blood sample, 60 (2.3%) tested positive for HBsAg. This is the largest, most geographically diverse survey of hepatitis B vaccination and HBsAg seroprevalence done in PNG. Progress has been made in PNG toward the Western Pacific Regional goal to reduce the prevalence of chronic HBV infection to 1% by 2017 among 5-year-old children. Vaccination efforts should be strengthened, including increasing BD coverage and completing the 3-dose series.

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Hepatitis B vaccination of newborn infants in rural China: evaluation of a village-based, out-of-cold-chain delivery strategy

Cited by 86 publications

References 9 publications

Prevalence of chronic hepatitis B virus infection after implementation of a hepatitis B vaccination program among children in three provinces in Cambodia

Prevalence of chronic hepatitis B virus infection after implementation of a hepatitis B vaccination program among children in three provinces in Cambodia

Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B

Hepatitis B Surface Antigen Seroprevalence Among Children in Papua New Guinea, 2012–2013

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