Hepatitis B Vaccination in Children Infected with Schistosoma Mansoni: Correlation with Ultrasonographic Data

Ghaffar, Y. A.; Kamel, M. A.; Wahab, M. F. Abdel; Dorgham, Laila Shehata; Saleh, Michael; Deeb, A. S. El

doi:10.4269/ajtmh.1990.43.516

Cited by 19 publications

(19 citation statements)

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“…Many studies have been conducted in an attempt to evaluate the aspects of immunity that might be impaired, but the mechanisms are not perfectly understood yet 10,11,15,21,22,28,29,34,36,50,54,55,59,60 .…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B and C virus markers among patients with hepatosplenic mansonic schistosomiasis

Aquino¹,

Chieffi

Catunda³

et al. 2000

Rev. Inst. Med. trop. S. Paulo

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SUMMARYPurpose: To evaluate the frequency and the consequences of the co-infection of hepatitis B and C viruses in patients with hepatosplenic schistosomiasis (HSS).Methods: B and C serologic markers, exposure to risk factors, biochemical assays, upper gastrointestinal endoscopies, and abdominal ultrasonograms were evaluated in 101 patients with HSS from 1994 to 1997. Whenever possible, PCR was tested and histopathological studies were reviewed.Results: At least one HBV virus marker was found in 15.8%, and anti-HCV was detected in 12.9% of the subjects. The seropositive subjects tended to be older than the seronegative ones. A history of blood transfusion was significantly related to the presence of anti-HCV. Three (18.75%) out of 16 subjects exposed to B virus were HBsAg positive. Eleven (84.6%) out of thirteen patients who were anti-HCV positive demonstrated viral activity. Patients with ongoing viral infection presented a higher average level of liver aminotransferases, a higher frequency of cell decompensation and a higher rate of chronic hepatitis. Portal hypertension parameters were not influenced by viral exposure. Conclusions:The rate of hepatitis B and C viruses serologic markers observed in the patients with HSS was higher than the control group. The co-infection was responsible for a higher frequency of cell decompensation.

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Section: Introductionmentioning

confidence: 99%

Hepatitis B and C virus markers among patients with hepatosplenic mansonic schistosomiasis

Aquino¹,

Chieffi

Catunda³

et al. 2000

Rev. Inst. Med. trop. S. Paulo

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“…In another study, 32% of patients with uncomplicated schistosoma mansoni or schistosoma hematobium infections had HBsAg and 40% had anti-HBsAg and/or antibodies against hepatitis B core antigen [11]. Conversely, in another study, the prevalence of anti-HBsAg was 53.7% and 55.2% among cases and controls, respectively [12]. However, in the latter study, controls included patients with "low-grade" schistosoma mansoni infection.…”

Section: Discussionmentioning

confidence: 87%

“…On receiving HBV vaccine, schistosomiasis patients showed a diminished response to the vaccine [12,13]. However, both studies included a small number of patients that averts any compelling conjecture.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Hepatitis B Surface Antigenemia among Patients with Schistosoma Mansoni

Al-Freihi

1993

Ann Saudi Med

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This case-control study was designed to determine the prevalence of persistent hepatitis B surface antigenemia (HBsAG) among patients with schistosoma mansoni and to rationalize their vaccination against hepatitis B virus (HBV) infection. Seventy consecutive patients with a confirmed diagnosis of schistosoma mansoni were matched for age, sex, nationality, and residence (for Saudis only) with 70 healthy controls. Despite identical mean ages, sex, and nationality distribution, 18 schistosomiasis patients (26%) had positive HBsAg as compared with only three of the controls (4%). The odd ratio for HBsAg antigenemia among patients as compared to controls was 7.73 (95% confidence interval (Cl) = 2-35.01, P = 0.0004. Neither sex nor nationality had any influence on the positive rate for HBsAg found in schistosomiasis patients. Patients with schistosomiasis and a concomitant positive HBsAg had significantly more derangement of their hepatic enzymes (14 out of 18; 78%) as compared with those without this viral serological marker (22 out of 52; 42%) (odd ratio -4.77; 95% Cl = 1.22-20.11; P = 0.009). I have concluded that patients with schistosoma mansoni are exposed to a higher risk of acquiring HBV infection and that concomitant schistosomiasis and HBV infection has a deleterious effect on hepatic enzymes as well as other liver functions. Prospective evaluation of the preventive role of HBV vaccine among these patients is warranted.

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“…In fact, Ghaffar et al 11 observed that the titers of anti-HBs were lower in children with schistosomiasis who received the vaccine after they acquired Schistosoma. The presence of Schistosoma infection reduced the response after primary vaccination.…”

Section: Discussionmentioning

confidence: 99%

“…With regard to HBV vaccine, Ghaffar et al 11 reported lower anti-HBs response in children with schistosomiasis, three and nine months after vaccination. However, Bassily et al 2 did not find any effects from maternal infection with Schistosoma mansoni on the anti-HBs titers of babies vaccinated at birth.…”

Section: O Objetivo Dessa Investigação Foi Avaliar Um Possível Efeitomentioning

confidence: 99%

Intestinal helminthes and/or Toxocara infection are unrelated to anti-HBs titers in seven-year-old children vaccinated at birth with recombinant hepatitis B vaccine

Monteiro

Fragoso

Foletto³

et al. 2007

Rev. Soc. Bras. Med. Trop.

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Hepatitis B Vaccination in Children Infected with Schistosoma Mansoni: Correlation with Ultrasonographic Data

Cited by 19 publications

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Hepatitis B and C virus markers among patients with hepatosplenic mansonic schistosomiasis

Hepatitis B and C virus markers among patients with hepatosplenic mansonic schistosomiasis

Prevalence of Hepatitis B Surface Antigenemia among Patients with Schistosoma Mansoni

Intestinal helminthes and/or Toxocara infection are unrelated to anti-HBs titers in seven-year-old children vaccinated at birth with recombinant hepatitis B vaccine

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