Hepatitis B Vaccination Amongst Medical Students: Is There a Need to Review Seroconversion Post Vaccination?

Kar, Premashis; Roy, Prabhat Gautam; Ayush, Gupta; Hazam, Rajib Kishore; Karra, Vijay Kumar

doi:10.7869/tg.488

Cited by 1 publication

(2 citation statements)

References 16 publications

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“…Tis fnding is inconsistent with a study by Middleman et al, which reported that higher BMI was signifcantly associated with lower rates of seroprotection [35]. Similarly, Kar et al also found that higher BMI was signifcantly associated with nonprotective levels of antibodies [15]. Te disparity in results could be attributed to our small sample size.…”

Section: Discussioncontrasting

confidence: 68%

“…Although it has been estimated that those who had received the full course of primary HBV vaccination would be protected for at least 20 years [13], the present study revealed seroprotection rate of 25.7% (anti-HBsAb >10 mIU/ml) among adolescents enrolled in the EPI programme. In contrast, previous studies reported seroprotection rates of 57.7%, 40%, and 74.2% in Egypt, Micronesia, and India, respectively [14][15][16]. Moreover, seroprotection levels of 86.8% and 90.0% were reported in two separate studies conducted in South Africa and Brazil, respectively [17,18].…”

Section: Discussionmentioning

confidence: 80%

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Evaluation of Immune Characteristics and Factors Associated with Immune Response following Hepatitis B Vaccination among Ghanaian Adolescents

Asamoah Sakyi,

Badu Gyapong,

Krampah Aidoo

et al. 2024

Advances in Virology

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Background. WHO recommends HBV-negative babies in high-prevalence (8%) countries receive anti-HBV vaccination. Ghana initiated mass immunization in 2002, but concerns remain about vaccine effectiveness and long-term protection. We evaluated immune characteristics and factors following hepatitis B vaccination among Ghanaian adolescents who received HBV vaccines. Methods. In this longitudinal cross-sectional study, 74 participants were enrolled from the Kumasi Metropolis, Ghana. Sociodemographic and lifestyle characteristics of participants were obtained using a questionnaire. Blood samples were obtained before and after booster administration for anti-HBsAg, IL-6, and IL-10 estimations using ELISA kit (Shanghai Chemical Ltd., China). Anti-HBsAg titers ≥10 mIU/ml were considered protective. Statistical analyses were done using SPSS version 26.0 and R programming language, p<0.05 was considered statistically significant. Results. We found 100% seroconversion rate, with 25.7% seroprotection rate (anti-HBsAg >10 mIU/ml). Gender (p=0.009), age (p=0.001), and exercising (p=0.044) were significantly associated with seroprotection. Following booster administration, 59.4% were hyporesponders (10 ≤ anti-HBsAg titre ≤99 mIU/ml) whilst 40.6% were good responders (anti-HBsAg titre ≥100 mIU/ml). Exercise (p=0.034) was significantly associated with immune response after booster administration. Moreover, we reported significant positive correlation between cytokines [IL-6 (r = 0.817, p<0.001) and IL-10 (r = 0.928, p<0.001)] and anti-HBsAg titre. Conclusion. Approximately two thirds of adolescents vaccinated at birth lack protective levels of antibodies against hepatitis B virus. Booster vaccines could aid in mounting protective levels of anti-HBsAg. Physical exercise was negatively associated with immune response to hepatitis B vaccinations.

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Section: Discussioncontrasting

confidence: 68%