Hepatitis B surface antigen, hepatocellular carcinoma and cirrhosis in Hong Kong: a necropsy study: 1963-1976

Abstract

IRe (eived 5 Alarclh 198() Accepted( 10 Jtiine 198() Summary.-Hepatitis B surface antigen (HBsAg) was stained in liver tissue in 7100 of 496 cases of cirrhosis with and without hepatocellular carcinoma (HCC)

Choline Deficiency, Partial Hepatectomy, and Liver Tumors in Rats and Mice

“…We have shown that several manipulations, including partial hepatectomy, iron injections and choline deficiency, enhanced the carcinogenicity of aflatoxin for rat liver (Table 2) and the presence of the cirrhotic liver appears to have a unique effect on the induction of liver carcinoma. This, of course, is similar to the observations in human populations where cirrhosis and hepatocellular carcinoma are often concomitants (20)(21)(22)(23)(24)(25).…”

Quantitative Analysis of Circulating Methylated DNA as a Biomarker for Hepatocellular Carcinoma

“…Table 1 summarizes the demographic information of the study participants. The high HBV prevalence in the HCC group is consistent with the fact that HBV infection is the most important etiologic factor for HCC in China (12 ). In contrast, the incidence of hepatitis C infection is very low.…”

Expression of heparin‐binding epidermal growth factor‐like growth factor in the hepatocytes of fibrotic rat liver during hepatocarcinogenesis

“… 9 Cirrhosis is the result of failure of the liver to return to normal after injury, and is characterized by diffuse fibrosis associated with parenchymal nodules. 9–13 It is well known that cirrho‐sis and HCC frequently coexist in the liver. 10–13 This coexistence suggests that chronic necroinflammatory hepatic disease plays a role in hepatocellular carcinogenesis.…”

“… 9–13 It is well known that cirrho‐sis and HCC frequently coexist in the liver. 10–13 This coexistence suggests that chronic necroinflammatory hepatic disease plays a role in hepatocellular carcinogenesis. 14 Growth factors are known to play many physiological roles in cell growth and differentiation and also are involved in the development and progression of cancer.…”